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  • 2000-2004  (26)
  • 1965-1969  (43)
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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  68. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 90. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 45. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20041019-20041023; Berlin; DOC04dguK4-1840 /20041019/
    Publication Date: 2004-10-20
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  Patientenbeteiligung bei medizinischen Entscheidungen; 2. Tagung des Förderschwerpunktes "Der Patient als Partner im medizinischen Entscheidungsprozess"; 20040325-20040327; Freiburg; DOC04pat20 /20040615/
    Publication Date: 2004-06-15
    Keywords: ddc: 610
    Language: German
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  Patientenbeteiligung bei medizinischen Entscheidungen; 2. Tagung des Förderschwerpunktes "Der Patient als Partner im medizinischen Entscheidungsprozess"; 20040325-20040327; Freiburg; DOC04pat21 /20040615/
    Publication Date: 2004-06-15
    Keywords: ddc: 610
    Language: German
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  • 4
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to investigate the effects of different doses of exogenous recombinant human tissue plasminogen activator (rt-PA) on the endogenous cerebral plasminogen–plasmin system in focal ischemia in rats. Ischemia was induced using the suture model. Each group of rats (n = 6) received either treatment (0.9, 9 or 18 mg rt-PA/kg body weight) or saline (control group) at the end of ischemia; a sham-operated group was added. The activity of the plasminogen activators was measured by casein-dependent plasminogen zymography. In the cortex urokinase (u-PA) rose from sham (no ischemia), 91 ± 7% to ischemia, 176 ± 10% (P 〈 0.005). Increasing rt-PA doses led to further significant (P 〈 0.001) cortical u-PA activation which was maximal at 18 mg: 249 ± 13%. An extreme increase in the u-PA activity was observed in the basal ganglia to 1019 ± 22% (P 〈 0.001). This increase was further aggravated by higher rt-PA doses (18 mg, 1236 ± 15%; P 〈 0.001). The t-PA level did not change I3R24 during (3 h ischemia followed by reperfusion for 24 h); however, during low and moderate doses of rt-PA, endogenous t-PA was reduced. In conclusion, while ischemia leads to a significant increase in u-PA, mainly in the basal ganglia, t-PA is not altered. Increasing doses of rt-PA lead to a further elevation of u-PA. Thus, u-PA seems to play a major role in the endogenous plasminogen activator system following focal cerebral ischemia.
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  • 5
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Principal neurons of the medial nucleus of the trapezoid body (MNTB) receive a synaptic input from a single giant calyx terminal that generates a fast-rising, large excitatory postsynaptic current (EPSC), each of which are supra-threshold for postsynaptic action potential generation. Here, we present evidence that MNTB principal neurons receive multiple excitatory synaptic inputs generating slow-rising, small EPSCs that are also capable of triggering postsynaptic action potentials but are of non-calyceal origin. Both calyceal and non-calyceal EPSCs are mediated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and N-methyl-d-aspartate (NMDA) receptor activation; however, the NMDA receptor-mediated response is proportionally larger at the non-calyceal synapses. Non-calyceal synapses generate action potentials in MNTB principal neurons with a longer latency and a lower reliability than the large calyceal input. They constitute an alternative low fidelity synaptic input to the fast and secure relay transmission via the calyx of Held synapse.
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  • 6
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Glutamate release in ischaemia triggers neuronal death. The major glial glutamate transporter, GLT-1, might protect against glutamate-evoked death by removing extracellular glutamate, or contribute to death by reversing and releasing glutamate. Previous studies of the role of GLT-1 in ischaemia have often used the GLT-1 blocker dihydrokainate at concentrations that affect transporters other than GLT-1 and which affect kainate, N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. In hippocampal slices from postnatal day 14 mice lacking GLT-1, the current response of area CA1 pyramidal cells to superfused AMPA and NMDA (which are not taken up) was unaffected, whereas the response to 100 µm glutamate was more than doubled relative to that in wild-type littermates, a finding consistent with a decrease in glutamate uptake. In response to a few minutes of simulated ischaemia, pyramidal cells in wild-type mice showed a large and sudden inward glutamate-evoked current [the anoxic depolarization (AD) current], which declined to a less inward plateau. In mice lacking GLT-1, the time to the occurrence of the AD current, its amplitude, the size of the subsequent plateau current and the block of the plateau current by glutamate receptor blockers were all indistinguishable from those in wild-type mice. We conclude that GLT-1 does not contribute significantly to glutamate release or glutamate removal from the extracellular space in early simulated ischaemia. These data are consistent with glutamate release being by reversal of neuronal transporters, and with uptake into glia being compromised by the ischaemia-evoked fall in the level of ATP needed to convert glutamate into glutamine.
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  • 7
    ISSN: 1432-0983
    Keywords: Key words Fungi ; gypsy-like LTR retrotransposon ; Solo-LTR ; Reverse transcriptase ; Repeat-induced point mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In the filamentous ascomycete Podospora anserina a 6,935-bp retrotransposon, Yeti, has been identified and characterized. It is flanked by a 5-bp target site duplication and contains long terminal repeats (LTRs) 354 bp in length. The LTRs show a high degree of identity to the previously reported repetitive element repa, a sequence suggested to represent a solo-LTR element of an unknown transposon. In the investigated Podospora strains, the number of complete Yeti copies is significantly lower than the number of repa elements, with up to 25 copies. Yeti appears to be inactive: it is highly degenerate and no transcripts of the element have been detected even in Podospora cultures grown under elevated stress conditions. The amino acid sequences deduced from Yeti display significant homology, particularly in the reverse transcriptase region, to those of other fungal retrotransposons, indicating that it is a member of the gypsy family. As suggested by the unusual dinucleotide content, degeneration of Yeti appears to be the result of a molecular mechanism resembling repeat-induced point mutation in Neurospora crassa.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-3932
    Keywords: Schlüsselwörter HIT Typ II ; Heparin-induzierte Thrombozytopenie ; White-clot-Syndrom ; Danaparoid ; Rekombinantes Hirudin ; Key words HIT type II ; Heparin-induced Thrombocyopenia ; White clot Syndrome ; Danaparoid ; Hirudin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract  The case of a 71-year-old patient is discussed in whom early occlusions of an implanted bypass and peripheral arteries developed after implantation of a femoropopliteal PTFE bypass and several reoperations. Heparin-induced thrombocytopenia (HIT) type II was suspected because of the intraoperative aspect of white clots and when platelet counts fell below 50% of initial levels. A platelet aggregation test confirmed the diagnosis. After discontinuing the heparin therapy and using danaparoid, the platelet count continued to fall, so cross-reactivity to this heparinoid was assumed and confirmed in a second laboratory test. We switched to an anticoagulation regimen with phenprocoumon and used hirudin for the perioperative prophylaxis when another reoperation was required. Problems confirming the diagnosis of HIT type II and difficulties in patients with cross-reactivity to other heparinoids are discussed.
    Notes: Zusammenfassung  Es wird über den Verlauf bei einer 71jährigen Patientin berichtet, bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu frühen Bypassverschlüssen und peripheren Gefäßokklusionen kam. Ein zusätzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund ”weißer Thromben” lenkte den Verdacht auf’ein White-clot-Syndrom bei Heparin-induzierter Thrombozytopenie Typ II, welche sich im Heparin-induzierten Plättchenaggregationstest (HIPA) bestätigte. Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na (Orgaran) kam es zu einem weiteren Abfall derThrombozyten. Der klini-sche Verdacht auf Kreuzreaktivität zu Danaparoid-Na wurde im HIPA-Test verifiziert. Im weiterem Verlauf erfolgte zunächst die Antikoagula- tion mit Phenprocoumon (Marcumar) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin (Refludan, Fa. Hoechst). Die Probleme bezüglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivität mit Orgaran werden diskutiert.
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  • 9
    ISSN: 1617-4623
    Keywords: Key words Filamentous fungi ; DNA transposon ; Fot1-like element ; Podospora anserina ; Repeat-induced point mutation (RIP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A degenerate DNA transposon, Pat, was identified in the genomes of various wild-type strains of the filamentous fungus Podospora anserina. In these strains, the number (approximately 20–25 copies per genome) and location of Pat sequences appear to be conserved. Two copies of Pat, one complete and one partial, were cloned and characterized. The sequence of the complete element is 1856 bp long and contains imperfect inverted terminal repeats (ITRs) of 53 bp. The target site duplication comprises the sequence TA. The amino acid sequence derived from one reading frame of Pat shows significant homology to members of the Fot1 family of transposons. However, this reading frame is interrupted by numerous stop codons. Since no transcripts of Pat were identified in different P. anserina strains grown under standard conditions and under increased stress, we conclude that none of the copies of Pat is active in the strains analyzed, under the environmental conditions investigated. Comparison of the sequences of the two cloned Pat sequences revealed 89% (589/747 nucleotides) identity. Most of the differences (82%, 129/158) can be attributed to transitions preferentially at CpA:TpG and CpT:ApG dinucleotides. The dinucleotide ratios in Pat are similar to those in a Neurospora crassa transposon which was subject to repeat-induced mutation (RIP), but differ significantly from those found in single-copy genes of P. anserina and in fungal DNA transposons not modified by this mechanism. Molecular analysis of the progeny of a cross between the wild-type strain and a transgenic strain in which a nuclear gene was duplicated by transformation yielded the first clear evidence that a RIP-like process is active in P. anserina.
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  • 10
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To explore aspects of cellular immune responses in the pathogenesis of periodontitis we analyzed phenotype and function of peripheral T cells. Two groups of subjects participated: one group consisted of 10 highly susceptible patients with severe periodontitis (mean age 29 years) and a control group consisted of 10 age, gender and race matched subjects with gingivitis. From all subjects peripheral blood was collected. The results showed that the numbers of CD3+, CD4+ and CD8+ T cells as well as the CD4/CD8 ratio, and the proliferative capacity of T cells, were not different between the two groups of subjects. Also, proportions of naive and memory T cells for both the CD4+ and CD8+ subpopulations were not different. Functional heterogeneity within the CD4+ and CD8+ T cell compartments was determined by intracellular analysis of interferon-γ(IFN-γ) and interleukin-4 (IL-4) production. On the basis of these latter analyses among CD4+ and CD8+ cells, T helper (Th) 1 or Th2 function and T cytotoxic (Tc) 1 or Tc2 function, respectively, could be deduced. No significant differences in proportions of CD4+ and CD8+ T cells positive for intracellular IFN-γ or IL-4 were observed between periodontitis patients and gingivitis controls; however a higher level of intracellular IL-4 in CD8+ T cells was seen in periodontitis patients. This might indicate that there is a shift towards a Tc2 function within the CD8+ T cell subpopulation. The current explorative study suggests that further research into the role of CD8+T cells in the pathogenesis of periodontitis is warranted.
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