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  • 1965-1969  (4)
Collection
Keywords
Publisher
Year
  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 77 (1965), S. 1030-1031 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Prüfung der Frage, ob ein Zusammenhang zwischen cancerogener und immunsuppressiver Wirkung von wichtigen Krebschemotherapeutica besteht, wurden 15 Substanzen am Hämagglutinationstest und am PlaqueTest nach Jerne auf ihre immunsuppressive Wirkung untersucht. Als Tiermaterial dienten männliche Ratten des Stammes Sprague-Dawley. Die Cytostatica wurden nach folgendem Schema an die Versuchstiere appliziert: 1. Einmalige i.v. Gabe von 40% der DL50, anschließend Immunisierung und Verfolgung der Immunreaktion. 2. i. v. Injektion von 7% der DL50, einmal wöchentlich über 14 Wochen, darauf Immunisierung und Beobachtung der Immunreaktion. Die chronische Applikation bei einer größeren Anzahl von Substanzen zur Immunsuppression als die nur einmalige Gabe. Nach dem bisherigen Stand der Untersuchungen besteht keine strenge Korrelation zwischen der cancerogenen und der immunsuppressiven Wirkung der 15 Cytostatica.
    Notes: Summary To investigate the question whether there is a connection between carcinogenic and immunosuppressive effects of important cancer chemotherapeutic drugs, 15 substances were examined for their immunosuppressive effect by the haemagglutination test and the plaque test according to Jerne. Male rats of the Sprague-Dawley strain served as animal material. The cytostatics were administered to the experimental animals according to the following scheme. 1. Single intravenous administration of 40% of DL50, ϕ followed by immunisation and checking of immunoreaction. 2. Intravenous injection of 7% of DL50, once a week for 14 weeks, followed by immunisation and observation of immunoreaction. The repeated administration leads to immunosuppression with a larger number of substances than the single one. According to the present state of investigations there is no strict correlation between the carcinogenic and immunosuppressive effects of the 15 cytostatics.
    Type of Medium: Electronic Resource
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