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  • 1945-1949  (7)
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  • 1
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary One of the authors has previously reported on a method which consists in the utilization of an artifical radioactive isotope (Zn63), suspended in a suitably prepared solution ofpectin, for the production oflocalized biological radiation effects. This « macromolecular occlusion » of the radioactive isotope enables one to perform intraperitoneal injections (in cases of cancer of the ovaries with severe metastatic peritoneal extension), evidently also instillations in cavernous organs, and furthermore direct intratumoral injections, without diffusion of the radioactivity outside the treated areas, as shown both by autoradiographs and controls of blood and urine specimens with a Geiger counter. The authors investigated further whether this procedure would also be suitable for obtaining, by means ofintravenous injections, alocalized radiation effect within thelungs, as presumably the radiozinc, held in the large molecules of pectin, could thus be retained in the pulmonary capillaries. Intravenous injections of such a pectin solution containing radiozinc were performed on rabbits, and autoradiographic controls gave evidence of this expected fixation within the lungs. For the purpose of preliminary clinical investigation 40 millicuries of Zn63 suspended in 6 cm3 of a 3 p. c. isotonic pectin solution were injectedintravenously in a female patient with mainly pulmonary metastases of a previously operated hypernephroma. This patient had been also submitted to X-ray therapy. In spite of a poor general condition, the injection was well tolerated. Autoradiographic controls showed quite clearly that the radioactivity remains precisely localized within the pulmonary areas. No radioactivity whatsoever was demonstrated with the counter in the urine eliminated by this patient after the injection, a fact which points to a rather amazing accuracy of the fixation of the radiozinc in the lungs. This first clinical experience seems quite interesting in view of improving the therapeutic possibilities of pathological, especially neoplastic pulmonary conditions.
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 20 (1948), S. 993-993 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 19 (1947), S. 435-435 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 21 (1949), S. 192-192 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 21 (1949), S. 1429-1430 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Cereal straw was partially hydrolyzed with dilute sulphuric or hydrochloric acid at elevated temperatures, yielding about 20% of matter assimilable byTorulopsis utilis (calculated on oven-dry straw), which consisted chiefly of xylose, with small amounts of glucose and acetic acid. 2. Experiments on a laboratory scale with non-fermentable substrates like ethanol and acetic acid showed that also in these cases an ample aeration is an essential condition for a good yield. 3. Acetic acid is harmful to the yeast, even in small concentrations, when the pH is lower than 5.0. 4. Small quantities of glucose or acetic acid stimulate the conversion of xylose byTorulopsis utilis. 5. With an adequate aeration and an initial pH of 5.5–6.0 (maintained at this level until the acetic acid has disappeared and then lowered to 4.0–4.5) satisfactory conversion rates and yields could be obtained on straw extracts as mentioned sub 1. 6. The results of the laboratory experiments mentioned sub 5 could be reproduced in a semi-technical installation with a capacity of 200 l straw extract. 7. Good results were obtained in this installation with aVogelbusch aeration device, while foaming could be adequately controlled by means of a rotating wire screen.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary It has been proved that methane fermentation of sodium and calcium acetates is strongly inhibited by both sodium and calcium sulphites. In the region of optimum pH of this fermentation (pH 6.0 to 6.5) a concentration of 0.003 to 0.01 % sodium sulphite is enough to produce perceptible inhibition. At a concentration of 0.1 % Na2SO3 methane fermentation was inhibited completely for some days. Hereafter a recovery took place, most probably due to the development of micro-organisms converting sulphites to H2S. At a pH higher than 6.5 methane fermentation was less sensitive to Na2SO3 and CaSO3.
    Type of Medium: Electronic Resource
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