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  • 1
    Publication Date: 2015-08-08
    Description: In physiological fluids and seawater, adhesion of synthetic polymers to solid surfaces is severely limited by high salt, pH, and hydration, yet these conditions have not deterred the evolution of effective adhesion by mussels. Mussel foot proteins provide insights about adhesive adaptations: Notably, the abundance and proximity of catecholic Dopa (3,4-dihydroxyphenylalanine) and lysine residues hint at a synergistic interplay in adhesion. Certain siderophores-bacterial iron chelators-consist of paired catechol and lysine functionalities, thereby providing a convenient experimental platform to explore molecular synergies in bioadhesion. These siderophores and synthetic analogs exhibit robust adhesion energies (E(ad) 〉/=-15 millijoules per square meter) to mica in saline pH 3.5 to 7.5 and resist oxidation. The adjacent catechol-lysine placement provides a "one-two punch," whereby lysine evicts hydrated cations from the mineral surface, allowing catechol binding to underlying oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maier, Greg P -- Rapp, Michael V -- Waite, J Herbert -- Israelachvili, Jacob N -- Butler, Alison -- New York, N.Y. -- Science. 2015 Aug 7;349(6248):628-32. doi: 10.1126/science.aab0556.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. ; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. ; Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu. ; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. Materials Department, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu. ; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26250681" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesiveness ; Adhesives/*chemistry ; Aluminum Silicates/chemistry ; Catechols/*chemistry ; Dihydroxyphenylalanine/*chemistry ; Hydrogen-Ion Concentration ; Lysine/*chemistry ; Molecular Mimicry ; Oxidation-Reduction ; Proteins/*chemistry ; Siderophores/*chemistry ; Titanium/chemistry
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-08-02
    Description: Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences are occasionally mobilized by the L1 machinery, a process called 3' transduction. Because 3' transductions are potentially mutagenic, we explored the extent to which they occur somatically during tumorigenesis. Studying cancer genomes from 244 patients, we found that tumors from 53% of the patients had somatic retrotranspositions, of which 24% were 3' transductions. Fingerprinting of donor L1s revealed that a handful of source L1 elements in a tumor can spawn from tens to hundreds of 3' transductions, which can themselves seed further retrotranspositions. The activity of individual L1 elements fluctuated during tumor evolution and correlated with L1 promoter hypomethylation. The 3' transductions disseminated genes, exons, and regulatory elements to new locations, most often to heterochromatic regions of the genome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tubio, Jose M C -- Li, Yilong -- Ju, Young Seok -- Martincorena, Inigo -- Cooke, Susanna L -- Tojo, Marta -- Gundem, Gunes -- Pipinikas, Christodoulos P -- Zamora, Jorge -- Raine, Keiran -- Menzies, Andrew -- Roman-Garcia, Pablo -- Fullam, Anthony -- Gerstung, Moritz -- Shlien, Adam -- Tarpey, Patrick S -- Papaemmanuil, Elli -- Knappskog, Stian -- Van Loo, Peter -- Ramakrishna, Manasa -- Davies, Helen R -- Marshall, John -- Wedge, David C -- Teague, Jon W -- Butler, Adam P -- Nik-Zainal, Serena -- Alexandrov, Ludmil -- Behjati, Sam -- Yates, Lucy R -- Bolli, Niccolo -- Mudie, Laura -- Hardy, Claire -- Martin, Sancha -- McLaren, Stuart -- O'Meara, Sarah -- Anderson, Elizabeth -- Maddison, Mark -- Gamble, Stephen -- ICGC Breast Cancer Group -- ICGC Bone Cancer Group -- ICGC Prostate Cancer Group -- Foster, Christopher -- Warren, Anne Y -- Whitaker, Hayley -- Brewer, Daniel -- Eeles, Rosalind -- Cooper, Colin -- Neal, David -- Lynch, Andy G -- Visakorpi, Tapio -- Isaacs, William B -- van't Veer, Laura -- Caldas, Carlos -- Desmedt, Christine -- Sotiriou, Christos -- Aparicio, Sam -- Foekens, John A -- Eyfjord, Jorunn Erla -- Lakhani, Sunil R -- Thomas, Gilles -- Myklebost, Ola -- Span, Paul N -- Borresen-Dale, Anne-Lise -- Richardson, Andrea L -- Van de Vijver, Marc -- Vincent-Salomon, Anne -- Van den Eynden, Gert G -- Flanagan, Adrienne M -- Futreal, P Andrew -- Janes, Sam M -- Bova, G Steven -- Stratton, Michael R -- McDermott, Ultan -- Campbell, Peter J -- 088340/Wellcome Trust/United Kingdom -- 091730/Wellcome Trust/United Kingdom -- 14835/Cancer Research UK/United Kingdom -- C5047/A14835/Cancer Research UK/United Kingdom -- G0900871/Medical Research Council/United Kingdom -- P30 CA006973/CA/NCI NIH HHS/ -- WT100183MA/Wellcome Trust/United Kingdom -- Department of Health/United Kingdom -- New York, N.Y. -- Science. 2014 Aug 1;345(6196):1251343. doi: 10.1126/science.1251343.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. ; Department of Physiology, School of Medicine-Center for Resesarch in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Spain. ; Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Department of Clinical Science, University of Bergen, Bergen, Norway. Department of Oncology, Haukeland University Hospital, Bergen, Norway. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Human Genome Laboratory, Department of Human Genetics, VIB and KU Leuven, Leuven, Belgium. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Department of Haematology, University of Cambridge, Cambridge, UK. ; University of Liverpool and HCA Pathology Laboratories, London, UK. ; Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. ; Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK. ; Institute of Cancer Research, Sutton, London, UK. University of East Anglia, Norwich, UK. ; Institute of Cancer Research, Sutton, London, UK. ; Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland. ; Johns Hopkins University, Baltimore, MD, USA. ; Netherlands Cancer Institute, Amsterdam, Netherlands. ; Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium. ; British Columbia Cancer Agency, Vancouver, Canada. ; Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. ; Cancer Research Laboratory, University of Iceland, Reykjavik, Iceland. ; School of Medicine, University of Queensland, Brisbane, Australia. Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia. UQ Centre for Clinical Research, University of Queensland, Brisbane, Australia. ; Universite Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon, France. ; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. ; Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. ; Dana-Farber Cancer Institute, Boston, MA, USA. ; Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. ; Institut Bergonie, 229 cours de l'Argone, 33076 Bordeaux, France. Institut Curie, Department of Tumor Biology, 26 rue d'Ulm, 75248 Paris cedex 05, France. ; Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp, Belgium. ; Royal National Orthopaedic Hospital, Middlesex, UK. UCL Cancer Institute, University College London, London, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. MD Anderson Cancer Center, Houston, TX, USA. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. Department of Haematology, University of Cambridge, Cambridge, UK. pc8@sanger.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25082706" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogenesis/genetics ; Chromatin/chemistry ; *DNA Transposable Elements ; Exons ; Genome, Human ; Humans ; *Long Interspersed Nucleotide Elements ; Mutagenesis, Insertional ; Neoplasms/*genetics ; *Transduction, Genetic ; Translocation, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2014-07-12
    Description: Peptidoglycan (PG) is a polysaccharide matrix that protects bacteria from osmotic lysis. Inhibition of its biogenesis is a proven strategy for killing bacteria with antibiotics. The assembly of PG requires disaccharide-pentapeptide building blocks attached to a polyisoprene lipid carrier called lipid II. Although the stages of lipid II synthesis are known, the identity of the essential flippase that translocates it across the cytoplasmic membrane for PG polymerization is unclear. We developed an assay for lipid II flippase activity and used a chemical genetic strategy to rapidly and specifically block flippase function. We combined these approaches to demonstrate that MurJ is the lipid II flippase in Escherichia coli.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163187/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163187/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sham, Lok-To -- Butler, Emily K -- Lebar, Matthew D -- Kahne, Daniel -- Bernhardt, Thomas G -- Ruiz, Natividad -- F32 GM103056/GM/NIGMS NIH HHS/ -- F32GM103056/GM/NIGMS NIH HHS/ -- R01 AI099144/AI/NIAID NIH HHS/ -- R01 GM076710/GM/NIGMS NIH HHS/ -- R01 GM100951/GM/NIGMS NIH HHS/ -- R01AI099144/AI/NIAID NIH HHS/ -- R01GM100951/GM/NIGMS NIH HHS/ -- R01GM76710/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):220-2. doi: 10.1126/science.1254522.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. ; Department of Microbiology, Ohio State University, Columbus, OH 43210, USA. ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. ; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. thomas_bernhardt@hms.harvard.edu ruiz.82@osu.edu. ; Department of Microbiology, Ohio State University, Columbus, OH 43210, USA. thomas_bernhardt@hms.harvard.edu ruiz.82@osu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25013077" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/*metabolism ; Escherichia coli/genetics/*metabolism ; Escherichia coli Proteins/antagonists & inhibitors/chemistry/*physiology ; Mesylates/pharmacology ; Models, Molecular ; Peptidoglycan/*biosynthesis/chemistry ; Phospholipid Transfer Proteins/antagonists & inhibitors/chemistry/*physiology ; Protein Conformation ; Uridine Diphosphate N-Acetylmuramic Acid/*analogs & derivatives/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2011-06-18
    Description: Variable x-ray and gamma-ray emission is characteristic of the most extreme physical processes in the universe. We present multiwavelength observations of a unique gamma-ray-selected transient detected by the Swift satellite, accompanied by bright emission across the electromagnetic spectrum, and whose properties are unlike any previously observed source. We pinpoint the event to the center of a small, star-forming galaxy at redshift z = 0.3534. Its high-energy emission has lasted much longer than any gamma-ray burst, whereas its peak luminosity was approximately 100 times higher than bright active galactic nuclei. The association of the outburst with the center of its host galaxy suggests that this phenomenon has its origin in a rare mechanism involving the massive black hole in the nucleus of that galaxy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levan, A J -- Tanvir, N R -- Cenko, S B -- Perley, D A -- Wiersema, K -- Bloom, J S -- Fruchter, A S -- Postigo, A de Ugarte -- O'Brien, P T -- Butler, N -- van der Horst, A J -- Leloudas, G -- Morgan, A N -- Misra, K -- Bower, G C -- Farihi, J -- Tunnicliffe, R L -- Modjaz, M -- Silverman, J M -- Hjorth, J -- Thone, C -- Cucchiara, A -- Ceron, J M Castro -- Castro-Tirado, A J -- Arnold, J A -- Bremer, M -- Brodie, J P -- Carroll, T -- Cooper, M C -- Curran, P A -- Cutri, R M -- Ehle, J -- Forbes, D -- Fynbo, J -- Gorosabel, J -- Graham, J -- Hoffman, D I -- Guziy, S -- Jakobsson, P -- Kamble, A -- Kerr, T -- Kasliwal, M M -- Kouveliotou, C -- Kocevski, D -- Law, N M -- Nugent, P E -- Ofek, E O -- Poznanski, D -- Quimby, R M -- Rol, E -- Romanowsky, A J -- Sanchez-Ramirez, R -- Schulze, S -- Singh, N -- van Spaandonk, L -- Starling, R L C -- Strom, R G -- Tello, J C -- Vaduvescu, O -- Wheatley, P J -- Wijers, R A M J -- Winters, J M -- Xu, D -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):199-202. doi: 10.1126/science.1207143. Epub 2011 Jun 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Warwick, Coventry, UK. a.j.levan@warwick.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21680811" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2011-06-28
    Description: The iron isotope composition of sedimentary pyrite has been proposed as a potential proxy to trace microbial metabolism and the redox evolution of the oceans. We demonstrate that Fe isotope fractionation accompanies abiotic pyrite formation in the absence of Fe(II) redox change. Combined fractionation factors between Fe(II)(aq), mackinawite, and pyrite permit the generation of pyrite with Fe isotope signatures that nearly encapsulate the full range of sedimentary delta(56)Fe(pyrite) recorded in Archean to modern sediments. We propose that Archean negative Fe isotope excursions reflect partial Fe(II)(aq) utilization during abiotic pyrite formation rather than microbial dissimilatory Fe(III) reduction. Late Proterozoic to modern sediments may reflect greater Fe(II)(aq) utilization and variations in source composition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guilbaud, Romain -- Butler, Ian B -- Ellam, Rob M -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1548-51. doi: 10.1126/science.1202924.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Geosciences, University of Edinburgh, Grant Institute, Edinburgh, UK. R.Guilbaud@sms.ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700871" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/metabolism ; Ferric Compounds/chemistry ; Ferrous Compounds/chemistry ; Geologic Sediments/chemistry ; Iron/*chemistry ; Iron Isotopes/*chemistry ; Oxidation-Reduction ; Sulfides/*chemistry
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2012-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Houweling, Sander -- Badawy, Bakr -- Baker, David F -- Basu, Sourish -- Belikov, Dmitry -- Bergamaschi, Peter -- Bousquet, Philippe -- Broquet, Gregoire -- Butler, Tim -- Canadell, Josep G -- Chen, Jing -- Chevallier, Frederic -- Ciais, Philippe -- Collatz, G James -- Denning, Scott -- Engelen, Richard -- Enting, Ian G -- Fischer, Marc L -- Fraser, Annemarie -- Gerbig, Christoph -- Gloor, Manuel -- Jacobson, Andrew R -- Jones, Dylan B A -- Heimann, Martin -- Khalil, Aslam -- Kaminski, Thomas -- Kasibhatla, Prasad S -- Krakauer, Nir Y -- Krol, Maarten -- Maki, Takashi -- Maksyutov, Shamil -- Manning, Andrew -- Meesters, Antoon -- Miller, John B -- Palmer, Paul I -- Patra, Prabir -- Peters, Wouter -- Peylin, Philippe -- Poussi, Zegbeu -- Prather, Michael J -- Randerson, James T -- Rockmann, Thomas -- Rodenbeck, Christian -- Sarmiento, Jorge L -- Schimel, David S -- Scholze, Marko -- Schuh, Andrew -- Suntharalingam, Parv -- Takahashi, Taro -- Turnbull, Jocelyn -- Yurganov, Leonid -- Vermeulen, Alex -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1038-40. doi: 10.1126/science.337.6098.1038-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22936755" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/*chemistry ; Carbon Dioxide/*analysis ; *Climate Change
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  • 7
    Publication Date: 2012-12-12
    Description: Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing African trypanosomiasis, and the tsetse (Glossina) vector remains a challenge. Metacyclic trypanosomes, which inhabit the tsetse salivary glands, transmit the disease and are produced through a complex differentiation and unknown program. By overexpressing a single RNA-binding protein, TbRBP6, in cultured noninfectious trypanosomes, we recapitulated the developmental stages that have been observed in tsetse, including the generation of infective metacyclic forms expressing the variant surface glycoprotein. Thus, events leading to acquisition of infectivity in the insect vector are now accessible to laboratory investigation, providing an opening for new intervention strategies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664091/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664091/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolev, Nikolay G -- Ramey-Butler, Kiantra -- Cross, George A M -- Ullu, Elisabetta -- Tschudi, Christian -- AI021729/AI/NIAID NIH HHS/ -- AI028798/AI/NIAID NIH HHS/ -- AI043594/AI/NIAID NIH HHS/ -- AI076879/AI/NIAID NIH HHS/ -- R01 AI021729/AI/NIAID NIH HHS/ -- R01 AI043594/AI/NIAID NIH HHS/ -- R21 AI076879/AI/NIAID NIH HHS/ -- R37 AI028798/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1352-3. doi: 10.1126/science.1229641.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06536, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Gene Expression Regulation ; Molecular Sequence Data ; Protozoan Proteins/genetics/*metabolism ; RNA-Binding Proteins/genetics/*metabolism ; Trypanosoma brucei brucei/genetics/*growth & development/*pathogenicity ; Tsetse Flies/*parasitology
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  • 8
    Publication Date: 2015-01-17
    Description: The physiological and biomechanical requirements of flight at high altitude have been the subject of much interest. Here, we uncover a steep relation between heart rate and wingbeat frequency (raised to the exponent 3.5) and estimated metabolic power and wingbeat frequency (exponent 7) of migratory bar-headed geese. Flight costs increase more rapidly than anticipated as air density declines, which overturns prevailing expectations that this species should maintain high-altitude flight when traversing the Himalayas. Instead, a "roller coaster" strategy, of tracking the underlying terrain and discarding large altitude gains only to recoup them later in the flight with occasional benefits from orographic lift, is shown to be energetically advantageous for flights over the Himalayas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bishop, C M -- Spivey, R J -- Hawkes, L A -- Batbayar, N -- Chua, B -- Frappell, P B -- Milsom, W K -- Natsagdorj, T -- Newman, S H -- Scott, G R -- Takekawa, J Y -- Wikelski, M -- Butler, P J -- BB/FO15615/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Jan 16;347(6219):250-4. doi: 10.1126/science.1258732.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, Bangor University, Bangor, Gwynedd, UK. ; School of Biological Sciences, Bangor University, Bangor, Gwynedd, UK. c.bishop@bangor.ac.uk l.hawkes@exeter.ac.uk. ; Wildlife Science and Conservation Center of Mongolia, Ulaanbataar, Mongolia. ; Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada. ; Office of the Dean of Graduate Research, University of Tasmania, Tasmania, Australia. ; Mongolian Academy of Sciences, Ulaanbataar, Mongolia. ; Emergency Prevention System(EMPRES) Wildlife and Ecology Unit, Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. ; Department of Biology, McMaster University, Ontario, Ontario, Canada. ; San Francisco Bay Estuary Field Station, Western Ecological Research Center, U.S. Geological Survey, Vallejo, CA 94592 USA. ; Max Planck Institut fur Ornithologie, Radolfzell, Germany. Department of Biology, University of Konstanz, Konstanz, Germany. ; School of Biosciences, University of Birmingham, Birmingham, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25593180" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; *Animal Migration ; Animals ; Biomechanical Phenomena ; Body Temperature ; Body Weight ; *Energy Metabolism ; Flight, Animal/*physiology ; Geese/*physiology ; Heart Rate ; Tibet ; Wings, Animal/*physiology
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  • 9
    Publication Date: 2011-06-18
    Description: Gas accretion onto some massive black holes (MBHs) at the centers of galaxies actively powers luminous emission, but most MBHs are considered dormant. Occasionally, a star passing too near an MBH is torn apart by gravitational forces, leading to a bright tidal disruption flare (TDF). Although the high-energy transient Sw 1644+57 initially displayed none of the theoretically anticipated (nor previously observed) TDF characteristics, we show that observations suggest a sudden accretion event onto a central MBH of mass about 10(6) to 10(7) solar masses. There is evidence for a mildly relativistic outflow, jet collimation, and a spectrum characterized by synchrotron and inverse Compton processes; this leads to a natural analogy of Sw 1644+57 to a temporary smaller-scale blazar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, Joshua S -- Giannios, Dimitrios -- Metzger, Brian D -- Cenko, S Bradley -- Perley, Daniel A -- Butler, Nathaniel R -- Tanvir, Nial R -- Levan, Andrew J -- O'Brien, Paul T -- Strubbe, Linda E -- De Colle, Fabio -- Ramirez-Ruiz, Enrico -- Lee, William H -- Nayakshin, Sergei -- Quataert, Eliot -- King, Andrew R -- Cucchiara, Antonino -- Guillochon, James -- Bower, Geoffrey C -- Fruchter, Andrew S -- Morgan, Adam N -- van der Horst, Alexander J -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):203-6. doi: 10.1126/science.1207150. Epub 2011 Jun 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of California, Berkeley, CA 94720-3411, USA. jbloom@astro.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21680812" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Li, M., Santpere, G., Imamura Kawasawa, Y., Evgrafov, O. V., Gulden, F. O., Pochareddy, S., Sunkin, S. M., Li, Z., Shin, Y., Zhu, Y., Sousa, A. M. M., Werling, D. M., Kitchen, R. R., Kang, H. J., Pletikos, M., Choi, J., Muchnik, S., Xu, X., Wang, D., Lorente-Galdos, B., Liu, S., Giusti-Rodriguez, P., Won, H., de Leeuw, C. A., Pardinas, A. F., Brain; Span Consortium, Psych; ENCODE Consortium, Psych; ENCODE Developmental Subgroup, Hu, M., Jin, F., Li, Y., Owen, M. J., ODonovan, M. C., Walters, J. T. R., Posthuma, D., Levitt, P., Weinberger, D. R., Hyde, T. M., Kleinman, J. E., Geschwind, D. H., Hawrylycz, M. J., State, M. W., Sanders, S. J., Sullivan, P. F., Gerstein, M. B., Lein, E. S., Knowles, J. A., Sestan, N., Willsey, Oldre, Szafer, Camarena, Cherskov, Charney, Abyzov, Kozlenkov, Safi, Jones, Ashley-Koch, Ebbert, Price, Sekijima, Kefi, Bernard, Amiri, Sboner, Clark, Jaffe, Tebbenkamp, Sodt, Guillozet-Bongaarts, Nairn, Carey, Huttner, Chervenak, Szekely, Shieh, Harmanci, Lipska, Carlyle, Gregor, Kassim, Sheppard, Bichsel, Hahn, Lee, Chen, Kuan, Dang, Lau, Cuhaciyan, Armoskus, Mason, Liu, Slaughterbeck, Bennet, Pinto, Polioudakis, Franjic, Miller, Bertagnolli, Lewis, Feng, Sandman, Clarke, Williams, Del; Valle, Fitzgerald, Shen, Flatow, Zharovsky, Burke, Olson, Fulfs, Mattei, Hadjimichael, Deelman, Navarro, Wu, Lee, Cheng, Goes, Vaccarino, Liu, Hoffman, Gürsoy, Gee, Mehta, Coppola, Giase, Sedmak, Johnson, Wray, Crawford, Gu, van Bakel, Witt, Yoon, Pratt, Zhao, Glass, Huey, Arnold, Noonan, Bendl, Jochim, Goldy, Herstein, Wiseman, Miller, Mariani, Stoll, Moore, Szatkiewicz, Leng, Zhang, Parente, Rozowsky, Fullard, Hohmann, Morris, Phillips, Warrell, Shin, An, Belmont, Nyhus, Pendergraft, Bryois, Roll, Grennan, Aiona, White, Aldinger, Smith, Girdhar, Brouner, Mangravite, Brown, Collado-Torres, Cheng, Gourley, Song, Ubieta, Habegger, Ng, Hauberg, Onorati, Webster, Kundakovic, Skarica, Reimers, Johnson, Chen, Garrett, Sarreal, Reding, Gu, Peters, Fisher, Gandal, Purcaro, Smith, Brown, Shibata, Brown, Xu, Yang, Ray, Shapovalova, Francoeur, Sjoquist, Mastan, Kaur, Parikshak, Mosqueda, Ngo, Dee, Ivanov, Devillers, Roussos, Parker, Manser, Wohnoutka, Farnham, Zandi, Emani, Dalley, Mayani, Tao, Gittin, Straub, Lifton, Jacobov, Howard, Park, Dai, Abramowicz, Akbarian, Schreiner, Ma, Parry, Shapouri, Weissman, Caldejon, Mane, Ding, Scuderi, Dracheva, Butler, Lisgo, Rhie, Lindsay, Datta, Souaiaia, Roychowdhury, Gomez, Naluai-Cecchini, Beach, Goodman, Gao, Dolbeare, Fliss, Reddy, Chen, Hyde, Brunetti, Lemon, Desta, Borrman, Haroutunian, Spitsyna, Swarup, Shi, Jiang, Xia, Chen, Jiang, Wang, Chae, Yang, Kim, Riley, Krsnik, Deng, Weng, Lin, Li
    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-12-14
    Description: To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type–specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C , SATB2 , SOX5 , TCF4 , and TSHZ3 ) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
    Keywords: Neuroscience, Online Only
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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