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    Publication Date: 2011-04-30
    Description: Grid cells in parahippocampal cortices fire at vertices of a periodic triangular grid that spans the entire recording environment. Such precise neural computations in space have been proposed to emerge from equally precise temporal oscillations within cells or within the local neural circuitry. We found that grid-like firing patterns in the entorhinal cortex vanished when theta oscillations were reduced after intraseptal lidocaine infusions in rats. Other spatially modulated cells in the same cortical region and place cells in the hippocampus retained their spatial firing patterns to a larger extent during these periods without well-organized oscillatory neuronal activity. Precisely timed neural activity within single cells or local networks is thus required for periodic spatial firing but not for single place fields.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Julie -- Linder, Ashley N -- Leutgeb, Jill K -- Leutgeb, Stefan -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):592-5. doi: 10.1126/science.1201685.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527713" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Entorhinal Cortex/cytology/*physiology ; Hippocampus/cytology/*physiology ; Lidocaine/pharmacology ; Male ; Membrane Potentials ; Motor Activity ; Nerve Net/physiology ; Neural Pathways ; Neurons/*physiology ; Periodicity ; Rats ; Rats, Long-Evans ; Septum Pellucidum/drug effects/physiology ; *Space Perception ; *Theta Rhythm/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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