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  • 1
    Publication Date: 2018-10-23
    Description: Genome-wide association studies have recently illuminated that WDFY4 is genetically associated with systemic lupus erythematosus (SLE) susceptibility in various ethnic groups. Despite strong genetic evidence suggesting a role of WDFY4 in SLE pathogenesis, its functional relevance is largely unknown. In this study, we generated Wdfy4 B lymphocyte conditional knockout ( Wdfy4 -CKO) mice and found that loss of Wdfy4 led to a decrease in number of total B cells and several subpopulations of B cells in the periphery and a defect in the transition from the pro– to pre–B cell stage in bone marrow. Also, Wdfy4 -CKO mice showed impaired Ab responses as compared with controls when challenged with Ag. SLE phenotypes were effectively alleviated in Wdfy4 -CKO mice, with significantly diminished pristane-elicited production of autoantibodies and glomerulonephritis. Genetic silencing of WDFY4 in B cells increased lipidation of LC3 independent of p62 and Beclin1, which are essential proteins of canonical autophagy. Our in vivo and in vitro data suggest that WDFY4 facilitates noncanonical autophagic activity. Our findings provide a novel functional link underlying the mechanism of SLE in which WDFY4 influences B cell fate via noncanonical autophagy.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
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  • 2
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have observed an unusual hysteresis loop in rf power dependence of high-temperature superconductor (HTS) coplanar transmission lines. At 77 K and 1 GHz, the signal transmission was linear (insertion loss 〈0.1 dB) until the input power (Pin) reached a critical value of Pc=0.4 W. An abrupt drop by ∼37 dB in the transmitted power (Pout) was observed at Pin=Pc followed by a slow increase (Pout∝Pin0.62) for Pin(approximately-greater-than) Pc. As Pm was then decreased, it retraced the previous curve only until Pin=Pc. However, as Pin was reduced further Pout did not rise until Pin=158 mW, at which Pout started to increase rapidly and returned to the linear regime for Pin〈71 mW. Such a sharp transition and a strong hysteresis effect were unique to the HTS line whereas a gold line with an identical structure did not exhibit these characteristics. This behavior may be utilized for potential applications of new HTS microwave power (current) limiters and switches. Several possible origins for the hysteresis effect are proposed and discussed. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 2274-2276 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The surface impedance of superconducting YBa2Cu3O7 films as a function of temperature at 10 GHz has been measured in a parallel plate resonator geometry. The penetration depth λ(T), complex microwave conductivity σ(T), and quasiparticle scattering rate 1/τ(T) were also determined. After a rapid fall as T is lowered below Tc, the surface resistance Rs exhibits a linear dependence from 65 K down to 6 K. As T drops below Tc, the real part of the conductivity σ1 has a rapid rise, which is attributed to the observed dramatic increase in τ. The normal-fluid density shows a linear behavior at low temperatures, which is inconsistent with s-wave BCS superconductivity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 4275-4281 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Molecular dynamics has been employed to study the disordering and amorphization processes in SiC irradiated with Si and Au ions. The large disordered domains, consisting of interstitials and antisite defects, are created in the cascades produced by Au primary knock-on atoms (PKAs); whereas Si PKAs generate only small interstitial clusters, with most defects being single interstitials and vacancies distributed over a large region. No evidence of amorphization is found at the end of the cascades created by Si recoils. However, the structure analysis indicates that the large disordered domains generated by Au recoils can be defined as an amorphous cluster lacking long-range order. The driving force for amorphization in this material is due to the local accumulation of Frenkel pairs and antisite defects. These results are in good agreement with experimental evidence, i.e., the observed higher disordering rate and the residual disorder after annealing for irradiation with Au2+ are associated with a higher probability for the in-cascade amorphization or formation of a large disordered cluster. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Chaos 5 (1995), S. 43-47 
    ISSN: 1089-7682
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The movement disorder syndrome of tardive dyskinesia arises as a consequence of prolonged regimens of neuroleptic medication, and is characterized, although not exclusively, by jerky and sometimes rhythmical stereotypical motions in a wide range of muscle systems. It is well established that the degree and variability of tremor in tardive dyskinesia is greater than that in normal age-matched subjects. The findings from the current experiment show that the dimension of the tardive dyskinetic finger tremor time series is systematically lower than that evident in normal finger tremor. Furthermore, the variability of finger motion in both groups is inversely related to the dimension of the respective attractor dynamic. The neuroleptic medication appears to constrain the degrees of freedom regulated in organization of the motor system. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2018-04-14
    Description: Objectives There are few data on the relationship between health-related quality of life (HRQoL) and physical activity among elderly individuals with pre-diabetes. This study aimed to determine if differences existed in HRQoL between individuals with pre-diabetes who were physically active compared with those who were physically inactive in rural China. Design, setting and participants A cross-sectional survey was conducted among the elderly (greater double equals60 years) in rural communities in Yiyang City of China. Multistage cluster random sampling was carried out to select 42 areas, and interviews were conducted among 434 elderly individuals with pre-diabetes. Pre-diabetes was screened using an oral glucose tolerance test. Main outcome measures The Medical Outcomes Study 36-Item Short Form Health Survey questionnaire was used to measure HRQoL. Physical activity was assessed using the International Physical Activity Questionnaire. Multivariate analysis of covariance (MANCOVA) was used to test for differences in HRQoL between the physically active group and the inactive group. Results A total of 434 individuals with pre-diabetes were included in this study. The physical component summary (PCS) score of HRQoL was 42.1±10.2 and the mental component summary score was 46.4±8.9. A median total physical activity of 524 metabolic equivalent-min/week was reported. A significant MANCOVA model (Wilks’ =0.962, F (2,423)=8.44, P〈0.001) indicated that elderly individuals with pre-diabetes who were physically active reported higher PCS scores (M diff =5.2, P〈0.001, effective size=0.47) compared with those physically inactive after adjusting for the following covariates: age, gender, marital status, education, smoking, chronic disease, body mass index and waist:hip ratio. Conclusions The HRQoL of elderly individuals with pre-diabetes is poor in rural China. These findings demonstrated that elderly individuals with pre-diabetes who were physically active had higher PCS scores than those who were physically inactive. Furthermore, these results support the rationale for developing a physical activity intervention for HRQoL of individuals with pre-diabetes. Trial registration number ChiCTR-IOR-15007033; Results.
    Keywords: Open access, Public health
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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