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  • American Institute of Physics (AIP)  (4)
  • The American Association of Immunologists (AAI)  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 38 (1997), S. 501-523 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: All Z2×Z2-graded contractions preserving space isotropy and the grading induced by the time reversal aitch-theta and the discrete canonical transformation K exchanging coordinates and momenta are found for the Lie algebras C2≡sp(2,C), sp(2,R), C3≡sp(3,C), and sp(3,R). Some properties and physical aspects of these contractions are discussed, especially in connection with the algebraic formulation of nuclear collective models. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 36 (1995), S. 4489-4506 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: All Z2×Z2-graded contractions preserving the space isotropy with grading induced by the Π (space inversion) and aitch-theta (time reversal) automorphisms of the Lie algebras A3 and so(4,2) are listed. Some properties of these contractions are discussed. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 36 (1995), S. 4639-4666 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The method of group quantization described in the preceding paper [J. Math. Phys. 36, 4612 (1995)] is extended so that it becomes applicable to some parametrized systems that do not admit a global transversal surface. A simple completely solvable toy model is studied that admits a pair of maximal transversal surfaces intersecting all orbits. The corresponding two quantum mechanics are constructed. The similarity of the canonical group actions in the classical phase spaces on the one hand and in the quantum Hilbert spaces on the other hand suggests how the two Hilbert spaces are to be pasted together. The resulting quantum theory is checked to be equivalent to that constructed directly by means of Dirac's operator constraint method. The complete system of partial Hamiltonians for any of the two transversal surfaces is chosen and the quantum Schrödinger or Heisenberg pictures of time evolution are constructed. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 35 (1994), S. 405-425 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: G-graded contractions of the complex Lie algebra B2 and of its real forms are considered. It is found that a particular G=Z2×Z2 is a proper choice of the grading group preserved when graded contractions leading to Lie algebras of the kinematical groups of space–time are studied.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2018-11-20
    Description: Age-related thymic involution is characterized by a decrease in thymic epithelial cell (TEC) number and function parallel to a disruption in their spatial organization, resulting in defective thymocyte development and proliferation as well as peripheral T cell dysfunction. Deficiency of Klotho , an antiaging gene and modifier of fibroblast growth factor signaling, causes premature aging. To investigate the role of Klotho in accelerated age-dependent thymic involution, we conducted a comprehensive analysis of thymopoiesis and peripheral T cell homeostasis using Klotho -deficient ( Kl/Kl ) mice. At 8 wk of age, Kl/Kl mice displayed a severe reduction in the number of thymocytes (10–100-fold reduction), especially CD4 and CD8 double-positive cells, and a reduction of both cortical and medullary TECs. To address a cell-autonomous role for Klotho in TEC biology, we implanted neonatal thymi from Klotho -deficient and -sufficient mice into athymic hosts. Kl/Kl thymus grafts supported thymopoiesis equivalently to Klotho -sufficient thymus transplants, indicating that Klotho is not intrinsically essential for TEC support of thymopoiesis. Moreover, lethally irradiated hosts given Kl/Kl or wild-type bone marrow had normal thymocyte development and comparably reconstituted T cells, indicating that Klotho is not inherently essential for peripheral T cell reconstitution. Because Kl/Kl mice have higher levels of serum phosphorus, calcium, and vitamin D, we evaluated thymus function in Kl/Kl mice fed with a vitamin D–deprived diet. We observed that a vitamin D–deprived diet abrogated thymic involution and T cell lymphopenia in 8-wk-old Kl/Kl mice. Taken together, our data suggest that Klotho deficiency causes thymic involution via systemic effects that include high active vitamin D levels.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
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