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  • Blackwell Publishing Ltd  (45)
  • Editions INSERM ; Montrouge, France : J. Libby Eurotext  (1)
  • 1990-1994  (46)
  • 1970-1974
  • 1925-1929
  • 1993  (46)
Collection
Publisher
Years
  • 1990-1994  (46)
  • 1970-1974
  • 1925-1929
Year
  • 1
    Call number: 0420:22
    Keywords: Antineoplastic Agents / therapeutic use ; Neoplasms / drug therapy ; Neoplasms / genetics
    Pages: x, 115 p. : ill.
    ISBN: 274200016X
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    0420:22 departmental collection or stack – please contact the library
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  • 2
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We performed patch tests with Dermatophagoides pteronyssinus (Dp) antigen from 2 different sources in 355 non-randomly selected patients with atopic dermatitis(AD) and 398 subjects of a control group. The study demonstrated that contact sensitization to mites occurred in an appreciable% of AD cases(20.8%). Using commonly available assay products. The differences recorded between the 2 materials tested were related to the concentration of P1 antigen. Non-atopic patients rarely showed positive reactions to Dp (0.75%), when strict criteria for readings were applied and if 2 readings were performed, Patients with positive patch tests did not necessarily show positive immediate skin tests. It would be useful to carry out tests systematically in atopic patients, even if it is not yet known what modern treatment would be best for the patient. Laboratories still do not provide standardized house dust mite preparations measuring and codifying their biological acitivity for use in patch of better test materials, in syringes with homogeneous dispersion and concentration.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Erwinia carotovora subsp. atroseptica was mutage-nized and assayed for virulence in planta. Those mutants which exhibited reduced virulence (Rvi-) were assayed for growth rate, auxotrophy and extracellular enzyme secretion and seven mutants were found to be wild type for all of these phenotypes. When screened for other phenotypes, two were found to be non-motile. One mutant was complemented for motility by a heterologous gene library. A 2.7kb XmaIII-Clal complementing fragment was sequenced and the gene products were found to have similarity to flagella biosynthesis gene products from several bacteria. Further similarity was found to a pathogenicity protein from the plant pathogen Xanthomonas campestris pv. glycines and to the Spa pathogenicity proteins of the human pathogen Shigella fiexneri, which are involved in the surface presentation of antigens. These studies highlight the emergence of common themes in the molecular strategies employed by both plant and animal bacterial pathogens for the targeting of proteins involved in the elaboration of disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract – Fifty-four Inuit elders, representing 90% of the individuals 60 yr of age and older in three communities in the Keewatin region of the Canadian Northwest Territories, were examined for dental caries, periodonlal disease, levels of edentulism, and the fit and quality of denture prostheses. These elders had a mean of 2.8 ± 3.5 decayed teeth and a DMFT of 26 ± 13 which reflected significant tooth loss. The Root Caries Index for subjects with gingival recession was 19%. Periodontal pocket assessments revealed that 86% of the individuals examined had CPITN readings of either 3 or 4. Over one third of the elders were totally edentulous, most of them female. Only 41% of these individuals wore complete dentures. Denture fit assessment revealed that 36% of the complete maxillary dentures and 42% of the complete mandibular dentures fit poorly. The overall oral health findings for these Inuit elders differed from those found in other older populations; however, the present findings may be the norm for a population undergoing a cultural transition.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Many studies have focused on the epidemiology and pathogenesis of oral candidiasis in HIV infection. Little is known on the incidence and predisposing factors of asymptomatic oral Candida carriage in this setting, obviously an important issue in view of prophylaxis. To address this question. 261 consecutive HIV-infected individuals without clinical evidence of candidiasis were investigated. C. albicans was isolated from cultured oral cavity swabs of 63 subjects (24%). Colonization was significantly more frequent in IV drug users. CDC groups IV. and in subjects with lymphocytopenia. CD4+ cell depletion, or elevated beta-2 microglobulin. These data further suggest that oral candidiasis occurs in HIV infection as a result of C. albicans overgrowth and raise the question of primary antifungal prophylaxis in subjects with low CD4 counts and asymptomatic oral Candida carriage.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 58 (1993), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Samples were withdrawn during the manufacture of infant formulas to determine steps which may affect soluble and lipid-bound Ca and Zn, which were estimated after centrifugal separation of in vitro digested samples. Pasteurization did not significantly reduce solubility of Ca and Zn. Blends forewarmed at low temperature contained a smaller proportion of soluble Ca than skim milk, but Zn was not affected. Forewarming at high temperature reduced solubility of Ca. The solubility of Ca and Zn was lower in sterilized and spray-dried formulas than in blends forewarmed at low temperature. Though initial Ca and Zn levels were greater in infant formulas than in human milk, percentages of soluble Ca and Zn were not higher.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Over a period of 11 months, 38 patients submitted to coronary artery revascularization underwent intraoperative angioscopy of the coronary arteries and internal thoracic arteries. Fifty-nine lesions were observed, but only 31 stenoses responsible for coronary insufficiency were observed (33%). Forty-four distal anastomoses were explored (47%) but ten of these explorations were incomplete. None revealed technical failure of the anastomosis. Thirteen harvested left internal mammary arteries were explored. One of the explorations led to rejection of the graft due to an intimal fracture. Some tiny intimal flaps were observed in our experience, as in others. Although the iatrogenic origin of these lesions in relation to the introduction of the angioscope is obvious, it does not seem to influence the outcome of the operation. In our opinion, two main fields appear to be developing in coronary angioscopy: preoperative assessment of the quality of internal thoracic artery grafts, and control of distal graft anastomoses. The flexibility of the angioscopes and of the leading catheters must be improved to minimize the risk of arterial wall traumatic lesions. (J Card Surg 1993; 8:483–487)
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 41 (1993), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Migration to zero offset (MZO) is a prestack partial migration process that transforms finite-offset seismic data into a close approximation to zero-offset data, regardless of the reflector dips that are present in the data. MZO is an important step in the standard processing sequence of seismic data, but is usually restricted to constant velocity media. Thus, most MZO algorithms are unable to correct for the reflection point dispersal caused by ray bending in inhomogeneous media.We present an analytical formulation of the MZO operator for the simple possible variation of velocity within the earth, i.e. a constant gradient in the vertical direction. The derivation of the MZO operator is carried out in two steps. We first derive the equation of the constant traveltime surface for linear V(z) velocity functions and show that the isochron can be represented by a fourth-degree polynomial in x, y and z. This surface reduces to the well-known ellipsoid in the constant-velocity case, and to the spherical wavefront obtained by Slotnick in the coincident source-receiver case.We then derive the kinematic and dynamic zero-offset corrections in parametric form by using the equation of the isochron. The weighting factors are obtained in the high-frequency limit by means of a simple geometric spreading correction. Our analytical results show that the MZO operator is a multivalued, saddle-shaped operator with marked dip moveout effects in the cross-line direction. However, the amplitude analysis and the distribution of dips along the MZO impulse response show that the most important contributions of the MZO operator are concentrated in a narrow zone along the in-line direction. In practice, MZO processing requires approximately the same trace spacing in the in-line and cross-line directions to avoid spatial aliasing effects.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Heterogeneity of binding affinities for a variety of ligands was observed for γ-aminobutyric acid type A (GABAA) receptors in the rat CNS, at both GABA and ben-zodiazepine recognition sites. Photoaffinity labeling by [3H]flunitrazepam and [3H]muscimol to affinity column-purified receptor proteins was examined by gel electropho-resis in sodium dodecyl sulfate. Anesthetic barbiturates (pentobarbital) and steroids (alphaxalone) both differentially stimulated the incorporation of [3H]flunitrazepam more so into the 51-kDa α1 subunit than into the 53-kDa aL2 polypeptide, and incorporation of [3H]muscimol into the 55-kDa β2 subunit more so than the 58-kDaβ3 polypeptide. Binding to these polypeptides was also affected differentially by other allosteric modulators and competitive inhibitors, including the benzodiazepine “type 1” selective ligand CL218.872. Heterogeneity in affinity of this drug for the single 51-kDa α1 polypeptide strongly suggests that type I receptors, like type II, are heterogeneous. In brain sections, the extent of enhancement of [3H]muscimol binding showed significant regional variation, similar for both steroids and barbiturates, and the GABA analogues THlP and taurine inhibited muscimol binding with regional variations in affinity that were almost opposites of each other. Modulation of [3H]flunitrazepam binding by steroids, barbiturates, and THlP significantly varied with regions. Taken together, ligand binding heterogeneity exhibited by photoaffinity labeling and autoradiography demonstrate the existence of multiple pharmacological-binding subtypes resulting from the combination of multiple polypeptide gene products into several oligomeric isoreceptors. Comparison of the regional distribution of binding subtypes with that of different subunit gene products allows the following conclusions about possible subunit compositions of native pharmacological receptor subtypes present in the brain: Benzodiazepine pharmacology of the oligomeric receptor isofotms is dependent on the nature of α and subunits other than α, GABA-benzodiazepine coupling is dependent on the nature of the α subunits, GABA site pharmacology is dependent on the nature of the β sub-units, and several subunits including α and β contribute to the degree of sensitivity to steroids and barbiturates. Finally, the presence of discrete subunits may be necessary but is not sufficient to postulate a defined pharmacological property.
    Type of Medium: Electronic Resource
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