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  • Blackwell Publishing Ltd  (4)
  • Springer  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty patients undergoing major hepatobiliary or pancreatic surgery were randomly allocated to receive either 0.9% saline or Plasmalyte 148 (a balanced salt solution), at 15 ml.kg-1.h-1. Arterial blood gas analysis was performed before and after surgery. Plasma biochemistry (Na+, K+, Cl-, lactate) measurements were made before and after surgery and at 24 h after surgery. The patients receiving 0.9% saline had significantly increased chloride concentrations (p 〈 0.01), decreased standard bicarbonate concentrations (p 〈 0.01) and increased base deficit (p 〈 0.01) compared to those receiving Plasmalyte 148. There were no significant changes in plasma sodium or potassium or blood lactate concentrations in either group. The exclusive use of 0.9% saline intra-operatively can produce a temporary hyperchloraemic acidosis which could be given false pathological significance. In addition it may exacerbate an acidosis resulting from an actual pathological stale. The use of a balanced salt solution such as Plasmalyte 148 may avoid these complications.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Allergic squirrel monkeys when exposed to an aerosol ofAscaris suum either develop a reproducible, immediate bronchoconstriction or an immediate bronchoconstriction followed by a reproducible late response. Pretreatment of ascaris-challenged squirrel monkeys with a potent, selective, orally active 5-lipoxygenase inhibitor, L-651,392 (4-bromo-2,7-dimethoxy-3,4-phenothizin-3-one), at a dose of 5 mg/kg p.o. resulted in near complete inhibition of the increases in pulmonary resistance (R L) and decreases in dynamic compliance (Cdyn) normally observed following exposure to the antigen. A lower dose (1 mg/kg p.o.) of L-651-392 produced only a significant inhibition of the decreases in Cdyn. In monkeys known to develop dual responses to antigen, L-651,392 (5 mg/kg p.o.) significantly attenuated the immediate response and markedly inhibited the late response. These results suggest an important role for leukotrienes in primary and late phase allergen-induced bronchoconstriction.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The matrix metalloproteinases (MMPs) collagenase, gelatinase A (72 kDa gela-tinase), stromelysin, and their specific inhibitor TIMP-1 (tissue inhibitor of metalloproteinases), were immunolocalized using specific polyclonal antisera in gingival tissues from 21 patients with chronic inflammatory periodontal disease. Monoclonal antibodies against macrophages (Leu-M5), B cells (Leu-14), helper T cells (OKT4), suppressor T cells (OKT8) and the HLA-DR epitope were also used to identify leukocyte subsets. MMPs were observed in connective tissues at sites that histologically showed signs of remodelling. The number and distribution of positive cells varied widely, however, not only between individual biopsy specimens, but also within the same specimen. The same was true for the composition and distribution of the inflammatory cell infiltrate. Moreover, although there was a positive correlation between the number of MMP-producing cells and the severity of inflammation in some specimens, for others with comparable leukocyte subset scoring the number was reduced and sometimes absent altogether. Cells secreting MMPs were fibroblasts, macrophages and epithelial cells. It was not possible to determine unequivocally whether a MMP-positive cell within the connective tissue was a fibroblast or a macrophage, since the antisera recognise both fibroblast and macrophage MMPs and the different fixation requirements for MMPs (4% paraformaldehyde) and Leu-M5 (acetone) precluded co-localization on the same section. TIMP-1 was immunolocalized within connective tissue cells at sites of tissue remodelling. Our results support the hypothesis that tissue-derived MMPs may be involved in tissue remodelling in periodontal disease and conclusively demonstrate that epithelial cells may be involved as well as connective tissue cells.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 64 (1957), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tracheostomy in patients requiring prolonged artificial ventilation in intensive care is increasingly being performed by a percutaneous dilatational technique, in preference to the standard surgical method. Since its introduction numerous series have reported favourably on its general safety in the short-term, but there have been few reports of longer term follow-up of patients. We present four cases of laryngotracheal stenosis, a previously unreported complication associated with the technique, and discuss the relevance of these to the future practice of percutaneous tracheostomy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-1536
    Keywords: Key words Disruption ; Aggregates ; Size ; Fractal dimension ; Capillary flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Disruption of polystyrene latex aggregates, formed in 1 M citric acid/phosphate buffer solution at pH 3.8 through diffusion-limited colloid aggregation (DLCA) and in 0.2 M NaCl solution at pH 5.5 through reaction-limited colloid aggregation (RLCA), was studied with respect to aggregate size and fractal nature. This was achieved using small-angle laser scattering in conjunction with a specially designed sampling method, which brought about the elimination of the disruption of the aggregates caused by a commercial stirrer sample unit. Aggregations were carried out in a mixture of deuterium oxide and water instead of water alone as a solvent to minimise sedimentation resulting from the differences in density between the latex particles and the electrolytes. An initial “steady state” in terms of aggregate size and fractal dimension was found to occur after around 20 min and 2 days for DLCA and RLCA aggregates, respectively, at 25 °C. No aggregate disruption was detected for DLCA and RLCA aggregates after their passing through a capillary tube for shear rates up to 1584 and 2694 s−1, respectively. At higher shear rates, significant decreases in the aggregate volume-mean diameter, D[4, 3], occurred after shearing. The degree of reduction in D[4, 3] was larger for DLCA aggregates in comparison to RLCA aggregates. The results would suggest that DLCA aggregates were more subject to disruption during shearing. A high degree of disruption was observed in turbulent flow for both aggregates.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1536
    Keywords: Key words Latex particles ; Aggregates ; Fractal dimensions ; Image analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The fractal nature of latex particles and their aggregates was characterised by image analysis in terms of fractal dimensions. The one- and two-dimensional fractal dimensions, D 1 and D 2, were estimated for polystyrene latex aggregates formed by flocculation in citric acid/phosphate buffer solutions. The dimensional analysis method was used, which is based on power law correlations between aggregate perimeter, projected area and maximum length. These aggregate characteristics were measured by image analysis. A two-slopes method using cumulative size distributions of aggregate length and solid volume has been developed to determine the three-dimensional fractal dimension (D 3) for the latex aggregates. The fractal dimensions D 1, D 2 and D 3 measured for single latex particles in distilled water agreed well with D 1 = 1, D 2 = 2 and D 3 = 3 expected for Euclidean spherical objects. For the aggregates, the fractal dimension D 2 of about 1.67 ± 0.04 (±standard deviation) was comparable to the fractal dimension D 3 of approximately 1.72 ± 0.13 (±standard deviation), taking the standard deviations into account. The measured three-dimensional fractal dimension for latex aggregates is within the fractal dimension range 1.6–2.2 expected for aggregates formed through a cluster-cluster mechanism, and is close to the D 3 value of about 1.8 indicated for cluster formation via diffusion-limited colloidal aggregation.
    Type of Medium: Electronic Resource
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