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  • Blackwell Publishing Ltd  (3)
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  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The haemodynamic effects of propofol-fentanyl anaesthesia for elective cardiac surgery were compared in 24 patients with good left ventricular function (ejection fraction 〉 45%, left ventricular end-diastolic pressure 〈 16 mmHg) and nine patients with impaired function. Anaesthesia was induced withfentanyl 25 μg.kg−1 and pancuronium 0.1 mg.kg−1 and was maintained with a variable rate propofol infusion, mean rate 2.61 mg.kg−1.h−1 in the good ventricular function group and 2.71 mg.kg−1.h−1 in the impaired function group. Additional fentanyl 7.5 μg.kg−1 was given before sternotomy. Ventilation to normocarbia was with air and oxygen (Fio2 0.6). Haemodynamic measurements were made before induction, after tracheal intubation, before and after sternotomy and before aortic cannulation. There were no significant differences between the groups in any haemodynamic variables during the study. Twenty minutes after intubation both groups showed a decrease from pre-induction values in mean arterial pressure (p 〈 0.05) and left ventricular stroke work index (p 〈 0.05), the reduction in left ventricular stroke work index remaining significant during the prebypass period in both groups. There were no significant changes in right or left sided filling pressures, systemic vascular resistance or heart rate. The technique decreased cardiac work and effectively controlled the autonomic responses to sternotomy in both groups. This study suggests that propofol may be a suitable adjunct to opioid anaesthesia in patients with impaired ventricular function having cardiac surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 41 (1986), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vecuronium 0.1 mg/kg, puncuronium 0.1 mg/kg, vecuronium 0.075 mg/kg t pancuronium 0.025 mg/kg, vecuronium + pancuronium 0.05 mg/kg each and vecuronium 0.025 mg/kg + pancuronium 0.075 mg/kg were compared with respect to time tuken to onset oj effect, duration of clinical relaxation and intubation conditions in jive groups of 20 patients each. Thi. time to onset and intubating conditions were similar in all thc groups. indicating that the combinations have no advantage over the individual drugs. The duration of clinicul relaxation was 25 minutes with vecuronium, and increased as the proportion of pancuronium in the niixturc increased, being 56 minutes with pancuronium 0.I mg/kg.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 39 (1984), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect on heart rate of different rates of injection (10 seconds, 1, 3 und 5 minutes) of a fixed dose (neostigmine 2.5 mg and atropine 1.2 mg) and a weight-related dose (neostigmine 50 μg/kg and atropine 25 μg/kg) of neostigmine-atropine mixture given for the reversal of residual competitive neuromuscular block was studied in 196 healthy adult patients. In both series slow injection lessened and delayed the initial rise in heart rate. The subsequent fall in heart rate was less when the drugs were injected over 3 min compared with the 10 seconds and 1 minute injection groups but when given over 5 minutes there was a steady fall in heart rate, more so with the weight-related dose. It is recommended that a neostigmine and atropine mixture should be administered over 3 min.
    Type of Medium: Electronic Resource
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