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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 7 (1991), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract This case report describes the treatment of two immature teeth with anatomic anomalies which created plaque retentive areas and in one case occlusal disturbance. Periodontal and pulpal consequences were inevitable. Reshaping of the teeth was carried out which as expected led to exposure of the pulp in both instances. Pulp capping was then performed under aseptic conditions. The vitality of the teeth was maintained and continued root development was observed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 1 (1985), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Endodontic treatment with subsequent restoration of 3 immature incisors with horizontal fractures in the cervical region is described. In 1 tooth the fracture occurred supragingivally, whereas in 2 others the fracture was such that the root margins were between 1 and 2 mm subosseous. In these teeth proper access to the roots was established by means of orthodontic extrusion and/or periodontal surgery. After endodontic treatment, the gutta-percha was removed from the root canals to a level 2 to 3 mm apically to the osseous crest. The root canal dentin was acid-etched and a post to retain a crown was cemented into the canal with a composite resin. The resin will then penetrate into the dentinal tubules of the root canal walls and strengthen the root to such a degree that it becomes restorable. Semipermanent composite resin crowns and, in one instance, a more permanent porcelain crown were used to restore the teeth.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 1 (1985), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A lower 2nd molar with an anomalous root canal anatomy is described. The floor of the pulp chamber showed the usual anatomic configuration with 2 mesial and 1 distal canal orifices. The mesiolingual canal had a normal course. However, the mesiobuccal and the distal canals merged to form 1 single canal in the apical 3 mm of the root.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 1 (1985), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Clinical guidelines essential for accurate use of the electronic apex locator were developed. Common causes for inaccurate readings are described as well as ways to minimize inaccuracies. While strictly adhering to the developed clinical routines, the apex locator was used in a controlled experiment. The lengths of 127 root canals in human teeth, irrespective of diagnosis, were measured. With the instrument placed at the apical foramen, as assessed by the apex locator, a radiograph was taken with a parallelling technique. In 90.6% of the canals the tip of the instrument was assessed to be within 0.5 mm of the radio-graphic outline of the tooth. In 7% of the canals the instrument was 1 to 2 mm short. Only 2.4% of the instruments were up to 1 mm long. Under the strict clinical guidelines used, the apex locator was (bund to be a valuable aid both in routine endodontic treatment and in special clinical situations where the use of radiographs was not feasible.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of aqueous extracts of raw, baked and boiled areca nuts were tested on cultured human buccal mucosa fibroblasts. Cells were exposed to extract concentrations of 0, 50, 100, 150, 300 and 500 μg/ml. The arecoline and arecaidine content was determined in the extracts with HPLC and raw nut contained 5.5% in m. baked nut 6.6% mm and boiled nut 7.1% m/m. Extract concentrations of 50 to 150 μg/ml inhibited cell growth in a concentration-dependent manner but did not lead to total cell death during a 7 day period. However, total cell death did occur with concentrations of 300 and 500 μg/ml. It is concluded that areca nut extract is toxic to cultured fibroblasts and inhibits their proliferation in a concentration-dependent manner.
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: HLA–typing was carried out on 122 areca nut chewers who attended hospitals for complaints unrelated to the habit. The subjects were South Africans of Indian extraction. The study did not include haplotypes. Palpable fibrous bands in the mouth indicated oral submucous fibrosis. The subjects were divided into 4 groups based on specific oral symptoms and signs. Groups A and B were without fibrous bands. Group A (47 subjects) included those with one or no symptoms while group B (28 subjects) suffered from 2 to 7 oral symptoms. Group C (17 subjects) had oral symptoms and represented early or mild oral submucous fibrosis and exhibited at least one discrete palpable fibrous hand. Group D (30 subjects) were classic oral submucous fibrosis cases with multiple bands. The high occurrence of oral submucous fibrosis in this study group (39%) is similar to the occurrence in comparable age groups reported earlier–n South Africa and is conceivably due to the higher age range of the subjects and their relatively long exposure to the area nut. We were unable to demonstrate a specific pattern of HLA–antigen frequencies in chewers with or without the disease. Furthermore, there were no differences between the study population and the controls. It is concluded that there is not necessarily a HLA–associated susceptibility in oral submucous fibrosis.
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  • 7
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The expression of the tropomyosin genes in the rat nervous system was examined during the postnatal development of the cerebellum, using human-specific α-, β-, γ-, and d-tropomyosin cDNA probes and rat-specific α-, β-, and d-tropomyosin oligonucleotide probes. The β- and γ-genes do not seem to be expressed in the rat brain. The δ-tropomyosin gene produces two mRNAs: a major one of 2.4 kb, which is highly concentrated during the first postnatal week and then decreases fourfold in level until the age of 35 days, and a minor one of 2 kb, with the same developmental profile as the 2.4-kb mRNA. A 3-kb mRNA is expressed by the α-tropomyosin gene and is characteristic of the mature rat. The expression of the tropomyosin genes during the development of the rat cerebellum does not seem to be regulated through alternative splicing but rather implies the differential expression of two different isogenes. The multiple isoforms of tropomyosin produced during neuronal differentiation may be intimately involved in the regulation of the organization and function of actin microfilaments.
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 4 (1988), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract This case report describes the treatment of a maxillary right central incisor with an intra-alveolar horizontal root fracture in the coronal one-third of the root. Repositioning and immobilization of the coronal fragment were carried out. After 2 months the clinical examination revealed the pulp in the coronal fragment to be necrotic. Radiographically, a small periapical radiolucency was seen. Endodontic therapy was initiated and the pulp in the apical fragment proved to be necrotic as well. Instrumentation of the root canal through the fracture line and long-term calcium hydroxide treatment were carried out. One year later the radiograph indicated repair of the fracture with hard tissue. The tooth was then obturated with guttapercha and Grossman's sealer and restored with an acid–etch resin technique. At the 12-month follow-up examination the tooth was functionally and esthetically normal. Radiographically, the fracture line was not discernible and repair of the apical periodontitis had taken place.
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 2 (1986), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A method to strengthen a nonvital immature maxillary central incisor during long-term endodontic therapy is described. Calcium hydroxide paste was packed into the root canal space, then removed to a level 3 mm apically to the osseous crest. A layer of IRM cement was placed over the paste to provide a bacteria-tight seal. The coronal portion of the root canal as well as the pulp chamber were acid-etched and filled with a composite resin in an attempt to strengthen the tooth. Access to the root canal was maintained by means of a vaseline-coated plastic post placed centrally in the resin. After polymerization of the resin the post was removed and the space was sealed with zinc oxide and eugenol cement. After completion of the endodontic treatment the space was filled with the composite resin.
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  • 10
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of the investigation was to evaluate and compare the proliferation (growth) of mouth fibroblasts and skin fibroblasts from patients with oral submucous fibrosis (OSF). Material comprised fibroblasts from fibrous bands situated in the buccal mucosa and from the inner aspect of the forearm of 8 patients with classic features of OSF as well as fibroblasts from 6 buccal mucosa and 8 skin biopsy specimens from healthy non-areca nut chewing individuals. Cells were cultured for 8 days according to standard techniques. Their growth was monitored daily, under optimal conditions as well as exposure to concentrations of arecoline. The data were analyzed using regression analysis, analysis of variance and the Kruskal-Wallis test. We found no statistically significant differences between the proliferation patterns of oral and skin fibroblasts from patients or between those from patients and controls. The reaction of the cells exposed to concentrations of arecoline was similar; at low concentrations (0.1–10 μg/ml) normal growth was maintained, while 100 μg/ml inhibited growth. It is concluded that fibroblasts from mouths affected by OSF have proliferation patterns which fall within normal parameters, that the excessive collagen formation in established OSF is not due to increased fibroblast proliferation and that arecoline does not stimulate fibroblast proliferation.
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