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  • Nature Publishing Group  (7)
  • Blackwell Science Ltd  (1)
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 128 (1931), S. 639-639 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As is well known, the chemical evidence regarding the structure of the azides is far from being unambiguous, and four formulas have been proposed,1,2,3 ... Of these, 2 is ruled out because the central nitrogen atom would have a shared decet of valency electrons, which, for an ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 380-381 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently we have been able to study the associations between C. tricolor Lesueur and D. venosus (H. M. Edwards) in the Caribbean, and C. polypus Forskal and D. gemmatus (H. M. Edwards) at Hawaii. C. tricolor showed a response to shells that was similar to C. parasitica that is, it could transfer to ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1050-1050 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE electric dipole moments of the α- and β-salicylides (assumed to be disalicylides) were found to be 6.27 and 2.42 D. respectively in benzene solution. The solutions showed no change of polarization with time. The former, being definitely a disalicylide, may therefore be given the cis ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 130 (1932), S. 314-315 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have recently determined the total and the electron polarisations (the latter as the molecular refractivity for the mercury green line 5461) of nickel carbonyl in carbon tetrachloride solution at 0° C., and found values of 39.5 c.c. and 37.3 c.c. respectively. The latter value is somewhat ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 156 (1945), S. 601-602 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a recent letter, Burawoy1 remarked that the ethane-like structure ascribed by us2 to the dimeric form of aluminium trimethyl from electron diffraction investigations, and supported by Brockway and Davidson3, is most unlikely. He proposed an ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 64-66 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Polyacrylamide gel profiles of 32P-labelled RNA from C. thermosaccharolyticum exhibit an extra band that corresponds to an RNA species of about 160 nucleotides. The new species plus the normal 5S RNA together exist in approximate unit mole ratio to the 16S and 23S rRNAs. The new species is indeed ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 162 (1948), S. 104-104 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE electric dipole moments, in benzene solution at 25° C., of the following nuclear methylated styrenes have been measured: ... These values are approximately corrected for atom polarization. Otto and Wenzke1 report a value of 0.63 D for (I). The others appear not to have been ...
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  • 8
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Protein kinase B and glycogen synthase kinase-3 have been identified as susceptibility genes for schizophrenia and altered protein and mRNA levels have been detected in the brains of schizophrenics post-mortem. Recently, we reported that haloperidol, clozapine and risperidone alter glycogen synthase kinase-3 and β-catenin protein expression and glycogen synthase kinase-3 phosphorylation levels in the rat prefrontal cortex and striatum. In the current study, β-catenin, adenomatous polyposis coli, Wnt1, dishevelled and glycogen synthase kinase-3 were examined in the ventral midbrain and hippocampus using western blotting. In addition, β-catenin and GSK-3 were examined in the substantia nigra and ventral tegmental area using confocal and fluorescence microscopy. The results indicate that repeated antipsychotic administration results in significant elevations in glycogen synthase kinase-3, β-catenin and dishevelled-3 protein levels in the ventral midbrain and hippocampus. Raclopride causes similar changes in β-catenin and GSK-3 in the ventral midbrain, suggesting that D2 dopamine receptor antagonism mediated the changes observed following antipsychotic administration. In contrast, amphetamine, a drug capable of inducing psychotic episodes, had the opposite effect on β-catenin and GSK-3 in the ventral midbrain. Collectively, the results suggest that antipsychotics may exert their beneficial effects through modifications to proteins that are associated with the canonical Wnt pathway.
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