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  • Blackwell Science Pty  (3)
  • Wiley-Blackwell  (2)
  • German Medical Science GMS Publishing House; Düsseldorf  (1)
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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20091021-20091024; Berlin; DOCPO17-326 /20091015/
    Publication Date: 2009-10-16
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Wettability and antifogging effect on the surface of the transparent thin film of cellulose esters were studied by fixing chemically nonionic fluorocarbon surfactants on the film surface and were compared with the properties of the surface fixed with the corresponding nonionic hydrocarbon surfactants. These antifogging properties on the surfaces covered by the monomolecular layer of fluorocarbon surfactant were found to be more excellent than those of the nonionic hydrocarbon surfactants from the measurement of contact angle for water droplets and also from the data of Zisman's plots. The surface of the thin film setting in the closed chamber filled with water vapor at 60°C were confirmed to be transparent during a long time without fogging. Antifogging effect may be due to so-called double structure consisting of fluorocarbon and nonionic ethyleneoxide chains in the monomolecular layer.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Critical surface tensions γc of poly(vinyl butyral) and poly(vinyl benzal) multilayers built up by the Langmuir-Blodgett method were measured with polyhydric alcohols and n-alkanes. The γc values of both polymer multilayers increased with increasing pressures of the piston oils used to control pressures of polymers on the water surface during deposition. The γc value of poly(vinyl butyral) multilayers built up to lower pressure of the piston oil was approximately consistent with a crystalline hydrocarbon surface, while the γc value of the multilayer built up to higher pressure of the piston oil was approximately consistent with a - CH3 rather than a —CH2 —CH2— surface. All results for γc values of poly(vinyl benzal) multilayers were very close to the γc value of benzene ringrich surface. The γc value of the multilayer built up to lower pressure of the piston oil almost coincided with the γc value for amorphous polystyrene, while the γc value for the multilayer built up to higher pressure of the piston oil was in fair agreement with γc for an aromatic ring edge in the crystalline state. Values of γsd, the dispersion force contribution to the surface free energy of multilayers calculated by Fowkes' relation, were in fair agreement with the corresponding observed γc values, respectively. It is concluded from these measurements that orientations and surface structures in both polymer multilayers are affected by pressure change of piston oils. The properties on monolayers of two polymers at a air-water interface and on barium stearate multilayers are also presented.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 7 (2002), S. 0 
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of the present study was to evaluate the role of angiotensinogen (AGT) gene polymorphisms in the progression of IgA nephropathy (IgAN). The association of the haplotypes defined by A-20C and M235T, which correspond to G-6 A polymorphisms, with the severity of glomerular or interstitial lesions and renal prognosis were investigated.Patients with histologically proven IgAN were recruited after informed consent was obtained for the genetic study, which was approved by the ethics committee of our institute. Genomic DNA from each patient was prepared from peripheral blood leucocytes using an automatic DNA isolation system (NA-100, Kurabo, Osaka, Japan). A–C transition at nucleotide −20, G–A transition at −6, C–T transition at +68 and M235T variant at exon two in the AGT gene were determined as described previously.1,2The renal survival rate was analysed for 114 IgAN patients with a creatinine clearance (Ccr) level of 70 mL/min or greater and followed up more than 24 months. The patients with haplotype T235 and C-20 (n = 63) were compared with those without T235 and C-20 (n = 51) for age, sex, blood pressure, proteinuria, serum Cr, Ccr at the time of renal biopsy, drugs administered, and severity of renal histopathologic lesion.Light microscopic evaluation of all specimens was performed in a double blind fashion according to the grading classification described previously, including glomerular cellular proliferation, mesangial matrix increase, global or segmental sclerosis, endocapillary proliferation, leucocyte exudation, duplication of glomerular basement membrane, crescent formation, and tufts adhesion to Bowman’s capsule as well as tubulointerstitial lesions.3The Kaplan-Meier method and the Cox proportional hazards regression model analysed the time course from renal biopsy to end point (initiation of dialysis or sCr level doubled after the time of diagnosis). Several covariates were selected by a stepwise backward method and the effects of these covariates were expressed by a hazard ratio. P 〈 0.05 was considered statistically significant.The genotype distributions in the present study were not different from that in Hardy–Weinberg equilibrium. The genotype and allele frequencies of AGT variants were compatible with previous studies for Japanese population.1,4 Haplotype analysis showed a complete linkage disequilibrium between M235T and A-20C alleles (linkage-disequilibrium coefficient: D′, 1.00). Because the AGT gene variant at −20 was observed only in a subset of the 235T alleles, the following haplotypes were determined: T235 and C-20; T235 and A-20; and M235 and A-20. The incidence of hypertension was not different between each haplotype of AGT.An association study of histopathological findings revealed that patients with haplotype T235 and C-20 had significantly higher grading scores in crescent formation (P = 0.017) than those without haplotype T235 and C-20. Renal survival rate was significantly lower in the patients with haplotype T235 and C-20 (〈link href="#f1"〉Fig. 1, P = 0.003). The Cox proportional hazards regression model showed an increased hazard ratio (HR) for haplotype T235 and C–20 of 5.9 from multivariate analysis (〈link href="#f2"〉Fig. 2; 95% CI, 2.1–16.7; P 〈 0.001). Furthermore, in IgAN patients without administration of angiotensin I converting enzyme inhibitors (n = 77), renal survival rate was significantly lower in those with haplotype T235 and C–20 (P = 0.011).〈figure xml:id="f1"〉1〈mediaResource alt="image" href="urn:x-wiley:13205358:NEP19:NEP_19_f1"/〉Effect of AGT haplotype on the renal survival rate in IgAN patients. Solid and dashed lines represent the renal survival rate in the patients with and without haplotype T235 and C–20, respectively.〈figure xml:id="f2"〉2〈mediaResource alt="image" href="urn:x-wiley:13205358:NEP19:NEP_19_f2"/〉Cox proportional hazards regression model to test the predictors for renal survival time in multivariate analysis. Covariates were selected by stepwise backward analysis. U-protein, urinary protein; HT at renal biopsy, hypertensives at the time of renal biopsy; ACEI, angiotensin I converting enzyme inhibitor. The bars represent the 95% confidence intervals of hazard ratio.This work provides the evidence that the C–20 gene polymorphism of AGT, a subset of 235T alleles, is associated with histopathological severity of glomerular injury, and progression of renal dysfunction in Japanese patient with IgAN.
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