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  • 1
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: C1-esterase inhibitor (C1eIn) is an important modulator of complement activation via the classical pathway. Deficiencies or dysfunction involving this inhibitor underlie the condition of angioneurotic oedema.〈section xml:id="abs1-2"〉〈title type="main"〉Aim: The purpose of this report is to describe a female patient who presented at the age of 24 years with an apparently aggressive form of periodontitis and severe oedema, localised to the free gingival tissues. After 21 years of repeated surgical reduction of the gingiva, a diagnosis of C1eIn dysfunction was made.〈section xml:id="abs1-3"〉〈title type="main"〉Methods: Exhaustive serological investigations were performed along with histopathology.〈section xml:id="abs1-4"〉〈title type="main"〉Results: All investigations were unremarkable, until the function of the C1eIn molecule was investigated. These demonstrated a functional activity of only 29% and a raised C1q at 157 mg/l. Subsequent repeated investigation with careful specimen handling demonstrated undetectable levels of C1eIn and normal C1q. A diagnosis of C1eIn dysfunction was made, although at present it is unclear whether this represents an unusual variant of hereditary dysfunctional C1eIn deficiency. The patient was managed by various means, including steriodal and non-steroidal drugs, the latter forming part of her maintenance regime.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions: To our knowledge, this is the first case of angio-oedema localised to the free gingiva. The role of stress in the acute exacerbations of oedema and bone loss is discussed along with the diagnostic pitfalls associated with this case.
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  • 2
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Altered glycosylation of glycoconjugates is among the important molecular changes that accompany malignant transformation. The purpose of our study was to investigate clinical usefulness of circulatory levels of total and lipid bound sialic acid for early diagnosis and management of oral cavity cancer patients.Methods:  Blood samples were collected from 41 untreated oral cancer patients, 20 patients with oral pre-cancerous conditions (OPC) and 20 healthy subjects. Serum sialic acid (total and lipid bound) levels were measured spectrophotometrically.Results:  Serum levels of total and lipid bound sialic acid were significantly elevated (P 〈 0.001) in untreated oral cancer patients as compared to healthy individuals as well as patients with OPC. Multivariate analysis documented that the progressive rise in total and lipid bound sialic acid was significantly associated (P = 0.0001 and 0.039, respectively) with stage of malignant disease.Conclusion:  The data revealed significant elevations in sialic acid levels in oral cancer patients and suggested potential utility of these parameters in diagnosis as well as determining clinical stage of the malignant disease.
    Type of Medium: Electronic Resource
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