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  • Wiley-Blackwell  (1,082)
  • German Medical Science GMS Publishing House; Düsseldorf  (73)
  • National Academy of Sciences  (29)
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  • 1
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    Hoboken, N.J. : Wiley-Blackwell
    Call number: QC454:28
    Keywords: Spectrum Analysis ; Spectrum Analysis
    Pages: 262 p. : ill.
    ISBN: 9781119993797
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  • 2
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A random packing hydrodynamic simulator is designed specially to carry out experiments under reduced pressures with a counter-current flow air/water system. The simulator results (air/water system) compared to those obtained in a real packed distillation column (benzylchloride/ ethylbenzene system) show a good agreement between hydrodynamic parameters like pressure drop, flooding flow rate, and total liquid hold-up. Empirical relationships derived from the simulator experimental results are proposed allowing the calculation of the pressure drop in a packed distillation column, operating in the pressure range between 10 kPa and atmospheric pressure. The influence of reduced pressure on the HETP in the distillation column and interfacial area in the simulator was also investigated.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0935-6304
    Keywords: Liquid chromatography ; Supercritical fluid Chromatography ; Light scattering detection ; Pharmaceutical analysis ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The evaporative light scattering detector (ELSD) has been used in pharmaceutical analysis by liquid and supercritical fluid chromatography. An ELSD equipped with interchangeable interfaces enables the use of various eluents (UV- or non-UV-absorbing) in isocratic or gradient mode. Analyses were performed on several non-UV-absorbing excipients and active substances. The narrow spread of the response factors of the various compounds investigated has indicated that the detector is suitable for direct raw quantitation of unknown samples in stability studies.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0935-6304
    Keywords: Liquid chromatography ; Beet ; Carbohydrates ; Light scattering detection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An evaluation of the most commonly used HPLC system (reversed phase octadecyl sillica gel) was undertaken in order to determine the level of certain carbohydrates in molasses produced in the refining of sugar beet. Chromatographic parameters and purification operations prior to analysis are discussed in order to develop an analytical method permitting automation of sugar determination. A Zorbax ODS column (250 × 9.4 mm), water elution, and light scattering detection allow easy determination of glucose + fructose, sucrose, and raffinose in molasses using an internal standard (maltose).
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0886-1544
    Keywords: human lymphoblastoma cells ; microtubule organizing centers ; isolation centrioles ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A procedure adapted from that described by Mitchison and Kirschner [Nature 312:232-237, 1984] was used to isolate centrosomes from human lymphoid cells. High yields of homogeneous centrosomes (60% of the theoretical total, assuming one centrosome per cell) were obtained. Centrosomes were isolated as pairs of centrioles, plus their associated pericentriolar material. Ultrastructural investigation revealed: 1) a link between both centrioles in a centrosome formed by the gathering in of a unique bundle of thin filaments surrounding each centriole; 2) a stereotypic organization of the pericentriolar material, including a rim of constant width at the proximal end of each centriole and a disc of nine satellite arms organized according to a ninefold symmetry at the distal end and; 3) an axial hub in the lumen of each centriole at the distal end surrounded by some ill-defined material.The total protein content was 2 to 3 × 10-2 pg per isolated centrosome, a figure that suggests that the preparations were close to homogeneity. The protein composition was complex but specific, showing proteins ranging from 180 to 300 kD, one prominent band at 130 kD, and a group of proteins between 50 and 65 kD. Actin was also present in centrosome preparations.Functional studies demonstrated that the isolated centrosomes were competent to nucleate microtubules in vitro from purified tubulin in conditions in which spontaneous assembly could not occur. They were also very effective at inducing cleavage when microinjected into unfertilized Xenopus eggs.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0886-1544
    Keywords: maytansine ; vinblastine ; diphenylpyridazone ; colchicine ; taxol ; tubulin ; microtubule ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have investigated the effects of the microtubule poison rhazinilam on microtubule assembly in vivo and in vitro. In mammalian cells, rhazinilam mimics the effects of taxol and leads to microtubule bundles, multiple asters, and microtubule cold stability. In vitro, rhazinilam protected preassembled microtubules from cold-induced disassembly, but not from calcium ion-induced disassembly. Moreover, both at 0°C and at 37°C, rhazinilam induced the formation of anomalous tubulin assemblies (spirals). This process was prevented by maytansine and vinblastine, but not by colchicine. Preferential saturable and stoichiometric binding of radioactive rhazinilam to tubulin in spirals was observed with a dissociation constant of 5 μM. This binding was abolished in the presence of vinblastine and maytansine. In contrast, specific binding of radioactive rhazinilam to tubulin assembled in microtubules was undetectable. These results demonstrate that rhazinilam alters microtubule stability differently than taxol, and that the overall similar effects of rhazinilam and taxol on the cellular cytoskeleton are the consequence of two distinct mechanisms of action at the molecular level. © 1994 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: We developed the oxidation reaction of Cu(I) ion in aqueous hydrochloric solution by oxygen in a gas-lift capillary bubble column. The method of gas-liquid absorption with chemical reaction was used. Test data confirmed that the rate constant of the reaction is strongly affected by solution compositions, and that chloride ions induce an inhibition effect. The kinetical orders found are equal to 1 and 2 for oxygen and Cu(I) respectively. The influence of temperature on reaction rate constant showed the existence of a maximum value between 303 and 313K. The effect of gas-liquid of gas-liquid system on the liquid-side mass transfer coefficient kL was also investigated.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 18 (1995), S. 425-433 
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Turbidimetry has proved to be an efficient method for the quantitative study of powder agglomeration for particle sizes in the region of 1 μm. This work presents a new application of the technique for the agglomeration of α-alumina in water and in n-heptane. The method of determining the kinetic parameters of agglomeration from the initial time-evolution of turbidity is explained.Turbulent flow in the reactor has also been characterised by laser anemometry. From the turbulence intensity, the number of collisions per unit time is calculated and the agglomeration rate can therefore be determined.Good agreement is found between the values obtained respectively from turbidimetric and hydrodynamic measurements. Addition of KOH modifies the zeta potential of alumina in water and influences the agglomeration kinetics. This can also be quantitatively characterised by turbidimetry. The experimental results obtained for alumina particles of diameter 0.3 μm and 1 μm are interpreted according to the DLVO model of interaction between particles.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0934-0866
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Dispersion of monosized drops downstream a point injection in a grid-generated turbulence is studied. Influence of extra bodyforces is also investigated by use of ferrofluid drops and magnetic field. Datas are obtained through LDV and given for fluid and particles mean and fluctuant velocities. Presence probability repartition for particles downstream the injection is obtained by LDV counting.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The aim of the present investigation was to ascertain whether mass spectrometric analysis of glucose allows determination in small samples (0.01 nmol) of the sites and the extent of labelling of glucose produced by isolated liver cells from various gluconeogenic labelled precursors. The electron impact spectrum of the methyloxime pentatrimethylsilyl derivative of natural glucose affords fragment ions retaining specific carbon atoms, i.e. 1-2 (m/z 160), 1-2-3 (m/z 262), 3-4-5-6 (m/z 319), 4-5-6 (m/z 217), 5-6 (m/z 205), 6 (m/z 103). The mass fragmentography analysis of the same derivative of commercially available labelled glucose molecules (1-13C, 6-13C, 2-2H, 3-2H, 6,6-2H2) permitted evaluation of the degree of specificity of these fragment ions, and development of a calculation method for isotope incorporation. Using this methodology we found that incubation of hepatocytes with (2-13C)glycerol, (1,3-13C)glycerol or NaH13CO3 plus pyruvate or lactate produced (2,5-13C)glucose, (1,3,4,6-13C) glucose or (3,4-13C)glucose, respectively. The extent of labelling was measurable on individual carbon of the glucose molecule except for carbon 1. The lowest enrichment detectable on carbon 1-3 or 3 was found to be 0.5%. In conclusion, gas chromatography mass spectrometry is a reliable method for positional isotopic anlysis of 13C-labelled glucose, and appears useful in the study of the gluconeogenic pathway.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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