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  • 1
    Publication Date: 2018-06-14
    Description: Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies, Published online: 14 June 2018; doi:10.1038/s41416-018-0105-y Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
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  • 2
    Publication Date: 2018-03-20
    Description: Linear assembly of a human centromere on the Y chromosome Linear assembly of a human centromere on the Y chromosome, Published online: 19 March 2018; doi:10.1038/nbt.4109 Repeat regions in the human Y chromosome centromere are assembled using long-read nanopore sequencing.
    Print ISSN: 1087-0156
    Electronic ISSN: 1546-1696
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
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  • 3
    Publication Date: 2018-07-03
    Description: UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites, Published online: 02 July 2018; doi:10.1038/s41594-018-0084-y Using UbiSite, an antibody-based approach that specifically detects protein lysine and N-terminal ubiquitination, Blagoev and colleagues uncover lack of correlation between changes in protein ubiquitination and abundance upon proteasome inhibition.
    Print ISSN: 1545-9993
    Electronic ISSN: 1545-9985
    Topics: Biology , Medicine
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  • 4
    Publication Date: 2012-06-29
    Description: In 2011, 100 new nuclides were discovered. They joined the approximately 3,000 stable and radioactive nuclides that either occur naturally on Earth or are synthesized in the laboratory. Every atomic nucleus, characterized by a specific number of protons and neutrons, occupies a spot on the chart of nuclides, which is bounded by 'drip lines' indicating the values of neutron and proton number at which nuclear binding ends. The placement of the neutron drip line for the heavier elements is based on theoretical predictions using extreme extrapolations, and so is uncertain. However, it is not known how uncertain it is or how many protons and neutrons can be bound in a nucleus. Here we estimate these limits of the nuclear 'landscape' and provide statistical and systematic uncertainties for our predictions. We use nuclear density functional theory, several Skyrme interactions and high-performance computing, and find that the number of bound nuclides with between 2 and 120 protons is around 7,000. We find that extrapolations for drip-line positions and selected nuclear properties, including neutron separation energies relevant to astrophysical processes, are very consistent between the models used.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erler, Jochen -- Birge, Noah -- Kortelainen, Markus -- Nazarewicz, Witold -- Olsen, Erik -- Perhac, Alexander M -- Stoitsov, Mario -- England -- Nature. 2012 Jun 27;486(7404):509-12. doi: 10.1038/nature11188.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22739315" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    Nature Publishing Group (NPG)
    Publication Date: 2014-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsen, Bjorn R -- England -- Nature. 2014 Sep 25;513(7519):494-5. doi: 10.1038/nature13750. Epub 2014 Sep 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25231860" target="_blank"〉PubMed〈/a〉
    Keywords: Achondroplasia/*drug therapy/*pathology ; Animals ; Female ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use ; Male ; Receptor, Fibroblast Growth Factor, Type 3/*deficiency/*genetics ; Thanatophoric Dysplasia/*drug therapy/*pathology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2018-12-05
    Description: Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme, Published online: 04 December 2018; doi:10.1038/s41467-018-07015-1 Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2012-08-07
    Description: In plants, transport processes are important for the reallocation of defence compounds to protect tissues of high value, as demonstrated in the plant model Arabidopsis, in which the major defence compounds, glucosinolates, are translocated to seeds on maturation. The molecular basis for long-distance transport of glucosinolates and other defence compounds, however, remains unknown. Here we identify and characterize two members of the nitrate/peptide transporter family, GTR1 and GTR2, as high-affinity, proton-dependent glucosinolate-specific transporters. The gtr1 gtr2 double mutant did not accumulate glucosinolates in seeds and had more than tenfold over-accumulation in source tissues such as leaves and silique walls, indicating that both plasma membrane-localized transporters are essential for long-distance transport of glucosinolates. We propose that GTR1 and GTR2 control the loading of glucosinolates from the apoplasm into the phloem. Identification of the glucosinolate transporters has agricultural potential as a means to control allocation of defence compounds in a tissue-specific manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nour-Eldin, Hussam Hassan -- Andersen, Tonni Grube -- Burow, Meike -- Madsen, Svend Roesen -- Jorgensen, Morten Egevang -- Olsen, Carl Erik -- Dreyer, Ingo -- Hedrich, Rainer -- Geiger, Dietmar -- Halkier, Barbara Ann -- England -- Nature. 2012 Aug 23;488(7412):531-4. doi: 10.1038/nature11285.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, 1871Frederiksberg C, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22864417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arabidopsis/embryology/genetics/*metabolism ; Arabidopsis Proteins/genetics/*metabolism ; Biological Transport/drug effects ; Cell Extracts/chemistry ; Evolution, Molecular ; Gene Deletion ; Gene Library ; Genes, Plant/genetics ; Glucosinolates/*metabolism/pharmacology ; Monosaccharide Transport Proteins/deficiency/genetics/*metabolism ; Oocytes/drug effects/metabolism ; Organ Specificity ; Phloem/metabolism ; Protons ; Seeds/*metabolism ; Xenopus laevis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2012-03-01
    Description: After entering the cerebral cortex, sensory information spreads through six different horizontal neuronal layers that are interconnected by vertical axonal projections. It is believed that through these projections layers can influence each other's response to sensory stimuli, but the specific role that each layer has in cortical processing is still poorly understood. Here we show that layer six in the primary visual cortex of the mouse has a crucial role in controlling the gain of visually evoked activity in neurons of the upper layers without changing their tuning to orientation. This gain modulation results from the coordinated action of layer six intracortical projections to superficial layers and deep projections to the thalamus, with a substantial role of the intracortical circuit. This study establishes layer six as a major mediator of cortical gain modulation and suggests that it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636977/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636977/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsen, Shawn R -- Bortone, Dante S -- Adesnik, Hillel -- Scanziani, Massimo -- 5T32NS007220-28/NS/NINDS NIH HHS/ -- R01 NS069010/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Feb 22;483(7387):47-52. doi: 10.1038/nature10835.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, California 92093-0634, USA. srolsen@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22367547" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Mice ; Models, Neurological ; Neural Inhibition/radiation effects ; Neural Pathways/*physiology/radiation effects ; Neurons/physiology/radiation effects ; Photic Stimulation ; Synapses/metabolism/radiation effects ; Thalamic Nuclei/cytology/physiology/radiation effects ; Visual Cortex/anatomy & histology/*cytology/*physiology/radiation effects ; Visual Perception/*physiology/radiation effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2018-12-13
    Description: Inhibitors of ribosome biogenesis repress the growth of MYCN -amplified neuroblastoma Inhibitors of ribosome biogenesis repress the growth of 〈i〉MYCN〈/i〉-amplified neuroblastoma, Published online: 12 December 2018; doi:10.1038/s41388-018-0611-7 Inhibitors of ribosome biogenesis repress the growth of MYCN -amplified neuroblastoma
    Print ISSN: 0950-9232
    Topics: Medicine
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  • 10
    Publication Date: 2011-08-19
    Description: Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus (HIV)-infected donors with remarkably broad and potent neutralizing responses and rescued 17 new monoclonal antibodies that neutralize broadly across clades. Many of the new monoclonal antibodies are almost tenfold more potent than the recently described PG9, PG16 and VRC01 broadly neutralizing monoclonal antibodies and 100-fold more potent than the original prototype HIV broadly neutralizing monoclonal antibodies. The monoclonal antibodies largely recapitulate the neutralization breadth found in the corresponding donor serum and many recognize novel epitopes on envelope (Env) glycoprotein gp120, illuminating new targets for vaccine design. Analysis of neutralization by the full complement of anti-HIV broadly neutralizing monoclonal antibodies now available reveals that certain combinations of antibodies should offer markedly more favourable coverage of the enormous diversity of global circulating viruses than others and these combinations might be sought in active or passive immunization regimes. Overall, the isolation of multiple HIV broadly neutralizing monoclonal antibodies from several donors that, in aggregate, provide broad coverage at low concentrations is a highly positive indicator for the eventual design of an effective antibody-based HIV vaccine.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393110/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393110/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, Laura M -- Huber, Michael -- Doores, Katie J -- Falkowska, Emilia -- Pejchal, Robert -- Julien, Jean-Philippe -- Wang, Sheng-Kai -- Ramos, Alejandra -- Chan-Hui, Po-Ying -- Moyle, Matthew -- Mitcham, Jennifer L -- Hammond, Phillip W -- Olsen, Ole A -- Phung, Pham -- Fling, Steven -- Wong, Chi-Huey -- Phogat, Sanjay -- Wrin, Terri -- Simek, Melissa D -- Protocol G Principal Investigators -- Koff, Wayne C -- Wilson, Ian A -- Burton, Dennis R -- Poignard, Pascal -- R01 AI033292/AI/NIAID NIH HHS/ -- R01 AI084817/AI/NIAID NIH HHS/ -- England -- Nature. 2011 Sep 22;477(7365):466-70. doi: 10.1038/nature10373.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21849977" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/biosynthesis/immunology ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/*immunology ; Cell Line ; Epitope Mapping ; Epitopes/chemistry/immunology ; Glycoproteins/chemistry/immunology ; Glycosylation ; HEK293 Cells ; HIV/*classification/*immunology/isolation & purification ; HIV Antibodies/*immunology ; HIV Infections/immunology/therapy ; Human Immunodeficiency Virus Proteins/chemistry/immunology ; Humans ; Immune Sera/blood/immunology ; Molecular Sequence Data ; Neutralization Tests
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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