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  • Springer  (94)
  • Blackwell Scientific Publications  (5)
  • Annual Reviews  (1)
  • Blackwell Scientific Publications Inc.  (1)
  • 1990-1994  (101)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical geology 24 (1992), S. 675-691 
    ISSN: 1573-8868
    Keywords: compositional data ; co-regionalization ; regionalized composition ; additive-logratio transformation ; cross-covariance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract Like compositions in general, regionalized compositions present the problem of spurious spatial correlation. To avoid this problem, this paper uses the additive-logratio transformation of regionalized compositions, following techniques introduced over the last few years for the statistical analysis of compositional data. It leads to an appropriate definition of a spatial covariance structure to describe spatial dependence between regionalized variables subject to constant-sum constraints in the case of weak stationarity. To illustrate stated problems, simulated data are used.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 13 (1991), S. 215-219 
    ISSN: 1573-739X
    Keywords: Cimetidine ; Costs and cost analysis ; Drug utilization ; Epidemiology ; Omeprazole ; Ranitidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A pharmaco-epidemiologic study in hospitalized patients was carried out in order to establish the place and use of omeprazole (Losec®), a new and promising drug in the treatment of acid-related diseases. A comparison is made with cimetidine and ranitidine use. It appeared that prescribed omeprazole doses were high in relation to the established defined daily doses and that substitution of H2 receptor antagonists by omeprazole led to tremendously increased drug costs. From the clinical indication data it could be established that the drug was prescribed appropriately.
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  • 3
    ISSN: 1573-739X
    Keywords: AIDS ; Cytomegaloviruses ; Drug therapy ; Foscarnet ; Ganciclovir ; HIV infection ; Retinitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The most common ocular complication in patients with the acquired immunodeficiency syndrome (AIDS) is cytomegalovirus retinitis. Incidence figures vary from 20 to 76%. Patients with cytomegalovirus may suffer from mild visual impairment of one or both eyes, but as the disease progresses the retinitis will almost certainly lead to blindness. Although cytomegalovirus retinitis is not a life-threatening infection, it can largely diminish the patient's quality of life. Clinical trials for the treatment of cytomegalovirus retinitis with a number of antiviral drugs have resulted in two drugs of choice, ganciclovir and foscarnet. Both drugs have an initial efficacy with induction therapy of 80–90%, but maintenance therapy is always needed to prevent a relapse. To exclude systemic side-effects of ganciclovir, intravitreal administration has been investigated with good results. Combination therapy of foscarnet and ganciclovir may be worthwhile in resistant cytomegalovirus retinitis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biotherapy 2 (1990), S. 337-345 
    ISSN: 1573-8280
    Keywords: interleukin-3 ; IL-3 ; hemopoietic growth factors ; molecular biology ; biological effects ; applications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interleukin-3 (IL-3) is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells. In five mammalian species, including man, the gene encoding IL-3 has been isolated and expressed to yield the mature recombinant proteins. The human IL-3 gene encodes a protein of 133 amino acids with two conserved cysteine residues and 2 potential N-linked glycosylation sites; human native IL-3 has not been characterized. Comparison of the IL-3 genes revealed a more rapid evolutionary divergence than has been observed for other hemopoietic growth factors, and, hence, a more pronounced species specificity of the functional proteins was found. In agreement with its stimulatory action on immature multipotent cells, thein vivo actions of homologous recombinant IL-3 in nonhuman primates include a highly increased production of blood cells along the neutrophilic, eosinophilic and basophilic granulocyte as well as the monocyte, red cell and platelet lineages.
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  • 5
    ISSN: 1432-0762
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Incubation temperatures in vertebrates affect incubation periods, and in some reptiles incubation temperature determines sex ratios and some limited behavior. Here I present evidence that incubation temperature in pine snakes (Pituophis melanoleucus) affects not only incubation periods and posthatching behavior in the laboratory, but also the behavior of hatchlings required for successful emergence and survival. These behavioral differences have evolutionary implications for selection of hatchlings from particular temperature nests. With increasing temperature, incubation periods decreased in the laboratory. In addition, incubation temperature affected hatching and emergence times as well as movement speed and foraging ability. Hatchlings from medium temperature conditions emerged from nests in the field in less time than hatchlings incubated at high or low temperatures, and hatchlings from low temperatures moved slower and were less able to capture and eat mice in the laboratory than hatchlings incubated at medium or high temperatures. Taken together, these laboratory and field experiments suggest that hatchlings from low temperature nests, compared to those from higher temperature nests, would be less able to emerge, find food, and locate hibernation sites prior to the onset of cold temperatures in the New Jersey Pine Barrens. These results suggest that incubation temperature affects a whole range of behavior and that distributional ranges of reptiles and other poikilotherms could be affected by summer temperatures (via incubation period and subsequent behavior) as well as ambient winter temperatures.
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  • 6
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary High-performance liquid chromatography with electrochemical detection was applied to the estimation of glutathione, glutathione disulphide, ascorbic acid and dehydroascorbic acid in various tissues of man, animal, and plant. The simultaneous determination of glutathione and ascorbic acid in tissues was done by a coulometric method. Separation of glutathione and ascorbic acid and unequivocal substance identifications were performed on a 100×4.6 mm RP-18 Spheri 5 column. As mobile phase 0.015 mol/l o-phosphoric acid, pH 2.3 was used. Retention time of ascorbic acid was 5.0 min and of glutathione 10.0 min. Dehydroascorbic acid was determined after reduction to ascorbic acid with dithiothreitol. Glutathione disulphide was reduced at pH 7.5 by β-nicotinamide-dinucleotide phosphate and glutathione reductase, EC 1.6.4.2., to regenerate glutathione. To exclude interfering substances, several other compounds present in tissues and foods were investigated. This coulometric method is highly sensitive, specific and simple. Very low concentrations of ascorbic acid, glutathione, dehydroascorbic acid, and glutathione disulphide (〈500 pg/injection) could be analysed using this HPLC-ECD method.
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  • 7
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In the field of steel sheet characterization, chemical surface analysis plays a very important role. Surface composition effects the surface properties of the final product. At Voest-Alpine Stahl Linz the analysis techniques GDOS and EPMA are routinely used to characterize the steel sheet surface. Some fundamental experiments are here described for the optimization of GDOS depth resolution. In the documentation for a semiquantitative approach for steel sheet analysis, investigations and experience about minimum detection limits are presented. Self developed methods for concentration mapping and thickness mapping are described in the field of electron probe microanalysis; Also an EPMA depth profiling method is highlighted. Finally practical examples demonstrate the wide application range of the analysis methods.
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  • 8
    ISSN: 1619-7089
    Keywords: Cardiac transplantation ; Radionuclide ventriculography ; Left ventricular function ; Cardiac allograft rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Discrepant results have previously been reported concerning long-term left ventricular function in the human transplanted heart as assessed by radionuclide ventriculography. In this study, radionuclide ventriculograms were obtained at rest and during exercise in 19 patients 〈6 months, 7–12 months, 13–24 months and 〉24 months after transplantation. Ejection fraction decreased significantly from 〈6 months to 13–24 months after transplantation (rest: 69.1%±9.7% to 56.7%±8.3%, P〈0.05; exercise: 70.4%±11.3% to 59%±8%, P〈0.05). Heart rate increased significantly during exercise after 〉2 years (90.2±10.5 beats/min to 103.5±15 beats/min, P〈0.05) but not within 6 months after transplantation (98.5±12.8 beats/min to 99.07±15.8 beats/min). Left ventricular end-diastolic volume remained unchanged. Peak filling rate at rest decreased significantly from 4.2±0.96 edv/s 〈6 months after transplantation to 3.3±0.66 edv/s (P〈0.05) 13–24 months and 3.3±0.64 edv/s (P〈0.05)〉24 months after cardiac transplantation. Exercise peak filing rate did not change significantly. It is concluded that radionuclide ventriculography demonstrates a decrease in systolic left ventricular function in the long-term course after cardiac transplantation. A significant increase in exercise peak heart rate may be due to autonomic reinnervation. Differences in the literature concerning left ventricular function may be due to different observation intervals following cardiac transplantation.
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  • 9
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A mechanism is discussed which reproduces in simulations the oscillations during the methylene-blue catalyzed reduction of O2 by HS− in a continuous-flow, strirred tank reactor (CSTR). It contains 14 reactions and is based on experiments and simulations of simpler reactions including the reduction of MB+ by HS− in the absence and presence of O2 and the reactions of H2O2 and O2 with HS−. All experiments on component reactions as well as the CSTR oscillations can be simulated by the same set of reactions and rate constants. The major dynamic feature of the mechanism is the competition for MB. by the oxidizing agents O2 and H2O2 and the reducing agents HS− and HS.. The species MB. is the radical intermediate between the colored (MB+) and colorless (MBH) forms of methylene blue.
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  • 10
    ISSN: 1619-7089
    Keywords: Monoclonal antibody ; Radioactive ; NonHodgkin's lymphoma ; Radionuclide studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The lesion detection capability of a new technetium-99m labelled B-cell lymphoma monoclonal antibody (MoAb) imaging agent, LL2, was evaluated in 8 patients with non-Hodgkin's lymphoma and 1 patient with chronic lymphocytic leukaemia. The MoAb kit consists of a 1-vial, 1-mg Fab′ form of LL2 ready for instant labelling with technetium. The patients were injected with ∼ 925 MBq (25 mCi) of 99mTc-LL2 Fab′ (1 mg), and planar and single photon emission tomography (SPET) studies were performed at 3–4 h post injection and at 24 h. There was no evidence of thyroid or stomach activity up to 24 h. Uniform splenic uptake was seen in all patients. Two non-lymphoma patients were also administered with the same agent and demonstrated a similar splenic distribution; therefore, splenic targeting was not scored as tumour-specific. A total of 29 from 48 tumour sites were detected by scintigraphy, including tumours of various grades and histological types. Excluding 1 patient who had a large tumour burden of over 500 g, 29 of 33 lesions were detected. One patient was free of disease at the time of the study and had a negative scan. Another patient showed excellent targeting of gallium-negative sites in the liver and bone. The bone involvement was not known prior to the antibody study and was subsequently confirmed by a bone scan. Additional sites of MoAb localization could not be followed in this group, since most patients went on to radioimmunotherapy immediately following the 99mTc-LL2 study. However, these initial results suggest that this new 99mTc-labelled antibody imaging kit should be further investigated for its potential role in the staging and follow-up of lymphoma patients.
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