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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  126. Kongress der Deutschen Gesellschaft für Chirurgie; 20090428-20090501; München; DOC09dgch11286 /20090423/
    Publication Date: 2009-05-06
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20080430-20080504; Bonn; DOC08hnod305 /20080422/
    Publication Date: 2008-04-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 8; DOC31 /20081218/
    Publication Date: 2008-12-19
    Description: The provision of professional information in hospitals as well as the need of both physicians and purchasers to streamline the process by means of appropriate solutions challenge all players in the value chain. This article describes a case study from the evaluation of the status quo to the implementation of the resulting project steps.
    Description: Die umfassende Literaturversorgung in Kliniken und der gemeinsame Wunsch von Ärzten und Einkauf nach Optimierung durch den Einsatz geeigneter Lösungen stellt alle Betroffenen vor neue Herausforderungen. Der Artikel beschreibt eine Fallstudie von der Evaluierung der Ist-Situation bis zur Umsetzung der einzelnen Projektschritte.
    Keywords: subscription management ; journals ; online access ; provision ; optimization ; Gespag ; Swets ; SwetsWise ; migration to online ; Aboverwaltung ; Zeitschriften ; Online-Zugänge ; Bereitstellung ; Optimierung ; Gespag ; Swets ; Swetswise ; Umstellung auf Online ; ddc: 610
    Language: German
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20080430-20080504; Bonn; DOC08hnod297 /20080422/
    Publication Date: 2008-04-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 8; DOC04 /20130429/
    Publication Date: 2013-07-11
    Description: Background: Paromomycin is used for selective bowel decontamination (SBD) in patients undergoing bone marrow transplantation in many hospitals, but there are no published resistance data for this compound in the recent medical literature. The aim of this study was to investigate the in vitro activity of paromomycin against the common intestinal bacteria E. coli and P. aeruginosa .Methods: 94 E. coli isolates and 77 P. aeruginosa isolates derived from clinical specimens were tested by broth microdilution against paromomycin and amikacin, respectively, following the CLSI recommendations for testing amikacin.Results: 86 of 94 E. coli isolates (91%) and 71 of 77 P. aeruginosa isolates (92%) showed in vitro susceptibility to amikacin (MIC90 for both compounds: 16 µg/ml, range: 1-32 µg/ml for E. coli and 1-〉128 µg/ml for P. aeruginosa ). Paromomycin was active against 83/94 E. coli isolates (88%; MIC90: 32 µg/ml, range: 2-〉128 µg/ml), but showed poor in vitro activity against P. aeruginosa (3/77 isolates susceptible [4%]; MIC90: 〉128 µg/ml, range: 2-〉128 µg/ml).Conclusion: If SBD with inclusion of an aminoglycoside antibiotic is applied, paromomycin should not be used unless local resistance data provide evidence of a sufficient in vitro activity of this compound against P. aeruginosa .
    Description: Hintergrund: Paromomycin wird in zahlreichen Zentren bei Patienten, die vor einer Knochenmarktransplantation stehen, zur selektiven Darmdekontamination (SDD) eingesetzt. Dennoch findet sich in der Literatur keine Angaben der Resistenzlage Gram-negativer Bakterien gegenüber diesem Aminoglykosid-Antibiotikum. Ziel der vorliegenden Untersuchung war es, die In-vitro-Aktivität von Paromomycin gegen die typisch im Dickdarm habitierende Bakterien E. coli und P. aeruginosa zu bestimmen.Methoden: 94 E. coli -Isolate und 77 P. aeruginosa -Isolate, welche aus klinischem Probenmaterial isoliert wurden, wurden mittels Mikrodilutionsverfahren gegenüber Paromomycin und Amikacin getestet. Es wurden die CLSI Empfehlungen für Amikacin herangezogen. Ergebnisse: 86 von 94 E. coli -Isolaten (91%) und 71 von 77 P. aeruginosa -Isolaten (92%) zeigten In-vitro-Empfindlichkeit gegenüber Amikacin (MIC90 für beide Antibiotika: 16 µg/ml, range: 1-32 µg/ml für E. coli und 1-〉128 µg/ml für P. aeruginosa ). Paromomycin war aktiv gegenüber 83/94 E. coli -Isolaten (88%; MIC90: 32 µg/ml, range: 2-〉128 µg/ml), zeigte aber schwache In-vitro-Wirksamkeit gegenüber P. aeruginosa (3/77 Isolate empfindlich [4%]; MIC90: 〉128 µg/ml, range: 2-〉128 µg/ml).Schlussfolgerung: Sollte eine SDD routinemäßig mit Einschluss eines Aminoglykosid Antibiotikums durchgeführt werden, sollte Paromomycin nicht eingesetzt warden, außer bei Vorliegen lokaler Resistenzkenntnis für die In-vitro-Effektivität von Paromomycin gegenüber P. aeruginosa .
    Keywords: paromomycin ; P. aeruginosa ; E. coli ; minimal inhibitory concentration (MIC) ; selective bowel decontamination (SBD) ; Paromomycin ; P. aeruginosa ; E. coli ; Minimale Hemmkonzentration (MHK) ; Selektive Darm-Dekontamination (SDD) ; ddc: 610
    Language: English
    Type: article
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20181004-20181006; Wien; DOC18peg30 /20181008/
    Publication Date: 2018-10-09
    Keywords: ddc: 610
    Language: English
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  • 7
    ISSN: 1432-2242
    Keywords: Repeated DNA ; Restriction satellite ; RFLP ; Solanaceae ; Species-specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Highly repeated DNA of potato (Solanum sp.) was characterized by cloning various major repeated elements of the nuclear genome. The percentage of the nuclear genome of the specific fractions and the restriction enzyme patterns were determined in order to show the distribution and organization of the respective repeats in the genome of Solanum tuberosum cultivars, dihaploid breeding lines and in wild species of Solanum. Several of the clones obtained were represented in a high copy number but showed no informative RFLP patterns. More information was gained from ‘restriction satellite’ repeats. The clone pR1T320 was found to contain satellite repeats (360 bp in length) that are proportionally present in the genome of all Solanum species at frequencies, between 0.5% and 2.6% and which are differently organized. This repeat was also found in the genera Lycopersicon, Datura and Nicotiana. With various restriction enzymes characteristic RFLP patterns were detected. A more or less genus-specific element for Solanum was the 183-bp repeat (clone pSA287; between 0.2–0.4% of the nuclear genome) that was present in the majority of the Solanum species analyzed except S. kurtzianum, S. bulbocastanum and S. pinnatisectum. In a few wild species (prominently in S. kurtzianum, S. demissum and S. acaule) a specific repeat type was detected (clone pSDT382; repeat length approximately 370 bp) that could be used to trace the wild species introduced into S. tuberosum cultivars. The repeats analyzed together with the 18S, 5.8S and 25S ribosomal DNA (1.9–5.2%, corresponding to 1800-5500 rDNA copies) comprised approximately 4–7% of the Solanum genome.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2242
    Keywords: Hybrid identification ; Molecular evolution ; Repetitive DNA elements ; Satellite DNA ; Solanaceae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Species-specific repetitive DNA probes are a useful tool for the molecular identification of somatic hybrids. Therefore, the distribution of three repetitive DNA elements of Solanum was investigated in Solanum wild species, Solanum breeding lines, and in more distantly related species of the genera Lycopersicon, Nicotiana, and Datura. The clone pSCH15, obtained from S. circaeifolium, represents a new 168-bp repetitive element; it shows 73–79% sequence similarity to repetitive elements of S. brevidens and Lycopersicon species. The 163-bp element in pSBH6, cloned from S. bulbocastanum, turned out to be very similar (95% sequence homology) to the Lycopersicon element pLEG15/TGRI previously regarded to be present only in species of the genus Lycopersicon and in S. lycopersicoides. Lower sequence similarity of approximately 80% was observed to repetitive elements of S. brevidens which are organized differently. The repeats exhibited different degrees of specificity: by Southern hybridization the element represented by the clone pSBH6 could be detected in almost all Solanum species investigated here but only after long exposure to X-ray film. The previously described “Solanum-specific” element represented by the clone pSA287 was also found, although in a very low copy number, in Lycopersicon esculentum. Therefore, detection of the repetitive elements pSA287 and pSBH6 in those species in which the respective repeat is less represented depends on exposure time. In contrast, the element pSCH15 is prominently present only in a small number of Solanum wild species and — to some extent — in the diploid breeding lines as revealed after long exposure. Use of these repeated elements for the identification of specific genomes in protoplast-fusion hybrids between Solanum wild species and Solanum breeding lines, or between two breeding lines, was evaluated.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0584
    Keywords: Acute lymphoblastic leukemia BCR-ABL rearrangment ; Minimal residual diasease Polymerase chain reaction ; Autologous BMT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Residual leukemic cells are detectable at frequencies as low as 1 in 106 normal cells in patients with Philadelphia chromosome/BCR-ABL-positive leukemias in complete remission (CR) using reverse-transcriptase polymerase chain reaction (RT-PCR) with specific nested primers. The level of minimal residual disease (MRD) in the bone marrow (BM) and the peripheral blood (PB) may favor one of the two as the source for an autologous graft. In order to quantify MRD with RT-PCR we analyzed patients ficolled cells after limiting logarithmic dilutions in normal ficolled buffy-coat cells. In six patients with BCR-ABL-pos ALL who were in CR by conventional criteria (5 in CR1 and 1 in CR2), we studied a total of nine paired BM and PB samples prior to scheduled ABMT. A positive RT-PCR signals was detectable in all samples up to dilutions ranging from 1∶101 to 1∶103 in PB, and at higher titers ranging from 1∶103 to 1∶105 in the BM. The BM titers exceeded the corresponding PB titers in all nine sample pairs by at least 1 log. The mean difference was 1.55 log (geometric mean,n=9) and is statistically significant (p〈0.03). We conclude that residual leukemia in BCR-ABL-positive ALL preferentially locates in the BM compartment, and we assume that PB may yield autologous grafts with significantly less leukemic contamination.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract. The phenomenon of stroboscopic alternative motion exhibits five different percepts that are seen with an increase in the frequency of presentation: (a) succession, (b) fluttering motion, (c) reversible clockwise and counter-clockwise turning motion, (d) oppositional motion and (e) simultaneity. From a synergetic point of view the increase in frequency is a control parameter and the different percepts are order parameters with phase transitions in between. The neural network model of Carmesin and Arndt is applied to receive predictions about hysteresis and phase transitions between these order parameters. Empirical data show the different motion percepts (b), (c) and (e) have lognormal distributions. Following the theoretical model, it is argued that there are three different phases, (a), (c) and (e), with two continuous phase transitions, (b) and (d), between them. The experimental data substantially match the theoretical ssumptions.
    Type of Medium: Electronic Resource
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