Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: Bioinformatics ; Genetics ; Human Genetics ; Agriculture ; Bioinformatics ; Genetics and Genomics ; Human Genetics ; Agriculture ; Springer eBooks
    Description / Table of Contents: Introduction to biological data -- Computers and bioinformatics -- Sequence biological databases -- Biological databases -- Other biological databases -- Nucleic acid sequencing -- Tools and methods in analysis of simple sequences -- Tools and methods in analysis of complex sequences -- Structural bioinformatics -- Protein structure annotations -- Introduction to functional bioinformatics -- Biological networks – tools, methods and analysis -- Metabolomics -- Drug discovery: concepts and approaches -- Drug designing methods and analysis -- Molecular molecular docking -- Insilico pcr -- Modeling and optimization of molecular bio-systems to generate predictive models -- Index
    Abstract: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it mostly focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Unlike other bioinformatics books which are mostly theoretical, this book provides practical examples for the readers on state-of-the-art open source tools to solve biological problems. Flow charts of experiments, graphical illustrations, and mock data are included for quick reference. Volume I is therefore an ideal companion for students and early stage professionals wishing to master this blooming field
    Pages: XIV, 405 p. 193 illus., 186 illus. in color. : online resource.
    ISBN: 9783030026349
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: Bioinformatics ; Genetics ; Human Genetics ; Agriculture ; Bioinformatics ; Genetics and Genomics ; Human Genetics ; Agriculture ; Springer eBooks
    Description / Table of Contents: 1. Driving forces of Bioinformatics -- 2. Genetic association from RFLPs to millions of variant markers – Unravelling the genetic complexity of diseases -- 3. Diagnostic revolution post-Human Genome Sequence project: High throughput technologies and Bioinformatics -- 4. Genomic revolution driven Cancer Research -- 5. Chromosomal Microarray in the New High Throughput Technological and Bioinformatic Era -- 6. Finding a Needle in a Haystack: Variant Effect Predictor (VEP) to Prioritize Candidate Variants from Millions -- 7. Clinical Strategies for Developing Next-Generation Cancer Precision Medicine -- 8. Dental stem cells in regenerative medicine: Emerging trends and prospects in the era of bioinformatics -- 9. Multiple Analyte Profiling Technology (xMAP) coupled with Functional Bioinformatics Strategies: Potential Applications in Protein Biomarker Profiling in Autoimmune Inflammatory Diseases -- 10. Design and Development of Small Molecules from Somatic, Stem Cell Reprogramming and Therapy -- 11. Molecular Modeling and drug design techniques in Microbial Drug Discovery -- 12 -- Combinatorial designing of novel lead molecules towards the putative drugs targets of extreme drug resistant Mycobacterium tuberculosis: a future insight for molecular medicine -- Index
    Abstract: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies
    Pages: XV, 309 p. 75 illus., 72 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030183752
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-6784
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Hydrolytic and esterifying activities of lipase from Candida cylindracea adsorbed on rice husks were lost by dehydration using molecular sieve pellets and P2O5which removed 90-97% of the water after 9 days. However, only the esterifying activity of the enzyme was restored by gradual water transfer via the organic phase to the dried enzyme either by direct water addition or by using salt hydrates as water donors.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Die Arbeit behandelt Dissipationseffekte beim Wärmeübergang, verursacht durch Wirkungen zweiter Ordnung: Längs-und Querkrümmungen, Verdrängungsströmung, Freistromturbulenz und Gradienten der Stauenthalpie. Die klassische Definition des Rückgewinnfaktors wird erweitert. Die maßgebenden Differentialgleichungen mit Dissipation werden integriert und die Ergebnisse graphisch dargestellt.
    Notes: Abstract Effects of dissipation on heat transfer due to second order effects of longitudinal curvature, transverse curvature, displacement speed, external vorticity and stagnation enthalpy gradient are studied. Classical definition of recovery factor is extended to the second order boundary layer flows. The selfsimilar governing equations with dissipation are integrated numerically and results are displayed graphically.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Three mutations causing alpha-1-antitrypsin defiiency have been identified by gene amplification and direct DNA sequencing. In the Pi (proteinase-inhibitor) nullcardiff gene, the codon for aspartate at position 256 has mutated to encode valine. In Pi Mmalton and Pi I, the respective mutations are the deletion of the codon for a phenylalanine residue at position 51 or 52, and a single base substitution resulting in arginine being replaced by cysteine at position 39. Examination of the protein tertiary structure suggests that all of these mutations are likely to result in folding abnormalities that may explain the deficiency states.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By sequence analysis of the complete proteincoding region of the human alpha-1-antitrypsin gene using polymerase chain reaction techniques, we have characterised one of the normal variants, M3. We have identified a single point mutation between M1 Va1213 and M3 at codon position 376 which is a GAA(Glu) to GAC(Asp) transversion.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two single point mutations in the alpha-1-antitrypsin gene, resulting in AAT deficiency, have been characterised in heterozygotes by DNA amplification and direct sequencing. The mutations result in amino acid substitutions, Gly115→Ser and Ser−19→Leu, in the leader sequence, respectively, and have been designated Pi NullNewport and Pi Z Wrexham. In the two families studied the mutations occur on chromosomes which also carry the common mutation causing Z deficiency. Individuals with such a deficiency are, therefore, compound heterozygotes. It is not known if these particular mutations would only cause a mild form of AAT deficiency in the absence of the Z mutation as they do not appear to cause predictable folding abnormalities. They do, however, result in severe deficiency when the Z mutation occurs in the same gene.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A number of recent studies have implicated the angiotensinogen gene in the aetiology of essential hypertension in Caucasian, Japanese and African Caribbean subjects. We have genotyped 153 healthy white Caucasian subjects at a dinucleotide repeat polymorphism and seven diallelic sites in the coding or flanking regions of the angiotensinogen gene, including one polymorphism not previously studied. We have also documented patterns of linkage disequilibrium between polymorphisms. There is evidence of variation in the frequency of several mutations when compared with published results from other Caucasian control populations, possibly due to cryptic ethnic differences between these groups. This should be considered in the design and interpretation of studies of the angiotensinogen gene.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...