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  • 1
    ISSN: 1432-1238
    Keywords: Haemoglobin ; Dissociation curves ; Bohr factor ; Oximetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Oxygen-haemoglobin dissociation curves were determined on dogs' blood using a modified and miniaturised dissociation curve analyser. The Bohr factor describes the way in which pH varies the PO2 corresponding to a particular oxyhaemoglobin concentration. The factor was similar for three saturations and was little affected by whether the pH was changed by changing PCO2, or by adding fixed acid or alkali. The haemoglobin saturations in the mid-range tended to be lower than those predicted by the equation of Rossing and Cain (1966)
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  • 2
    ISSN: 1279-8509
    Keywords: CLL MRD ; IgH genes rearrangement ; PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the absence of specific chromosomal translocations the best method for detecting minimal residual disease (MRD) in B cell malignancies is based on the uniqueness of immunoglobulin (Ig) genes rearrangement. We here report a very sensitive method for assessing MRD in complete hematological remission (CHR) chronic lymphocytic leukemia (CLL) patients as defined by the international workshop on CLL (IWCLL). Patients: Twelve CLL patients in CHR and complete phenotypic remission (CPR) were included in the study. Eight of them received Fludarabine (FDR), one was treated by Chop regimen, and the remaining 3 were rescued by polychemotherapy followed by autologous bone marrow transplantation (ABMT). Methods: DNA extracted from peripheral blood lymphocytes (PBL) of each patient was amplified with VH family specific and framework 3 primers in 5′ and a consensus JH primer in 3′, before treatment and sequentially after the CPR completion. When no clonal rearrangement could be detected by this assay, the CDR3 sequence specific probe of the clone was used as the 3′ primer, associated to the VH family specific primer in 5′. PCR products were analyzed by classical procedures in agarose and/or acrylamide gels. Results: Mixtures of leukemic cells and normal PBL showed detection of a single leukemic cell among more than 105 normal cells. Four out of the 12 patients achieved molecular remission (MR) when employing CDR3 amplifification. All 3 autografted patients were in MR, whereas only one out of the 9 patients treated by chemotherapy alone achieved MR. When using a clone specific probe, a clonal signal was observed in all cases but one (ABMT). Results presented here confirm that MR may be achieved in a few cases of B-CLL. Further studies are needed to determine the exact relationship between MRD and clinical outcome.
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 128 (1931), S. 639-639 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As is well known, the chemical evidence regarding the structure of the azides is far from being unambiguous, and four formulas have been proposed,1,2,3 ... Of these, 2 is ruled out because the central nitrogen atom would have a shared decet of valency electrons, which, for an ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 380-381 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently we have been able to study the associations between C. tricolor Lesueur and D. venosus (H. M. Edwards) in the Caribbean, and C. polypus Forskal and D. gemmatus (H. M. Edwards) at Hawaii. C. tricolor showed a response to shells that was similar to C. parasitica that is, it could transfer to ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1050-1050 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE electric dipole moments of the α- and β-salicylides (assumed to be disalicylides) were found to be 6.27 and 2.42 D. respectively in benzene solution. The solutions showed no change of polarization with time. The former, being definitely a disalicylide, may therefore be given the cis ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 130 (1932), S. 314-315 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have recently determined the total and the electron polarisations (the latter as the molecular refractivity for the mercury green line 5461) of nickel carbonyl in carbon tetrachloride solution at 0° C., and found values of 39.5 c.c. and 37.3 c.c. respectively. The latter value is somewhat ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 156 (1945), S. 601-602 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a recent letter, Burawoy1 remarked that the ethane-like structure ascribed by us2 to the dimeric form of aluminium trimethyl from electron diffraction investigations, and supported by Brockway and Davidson3, is most unlikely. He proposed an ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 64-66 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Polyacrylamide gel profiles of 32P-labelled RNA from C. thermosaccharolyticum exhibit an extra band that corresponds to an RNA species of about 160 nucleotides. The new species plus the normal 5S RNA together exist in approximate unit mole ratio to the 16S and 23S rRNAs. The new species is indeed ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 162 (1948), S. 104-104 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE electric dipole moments, in benzene solution at 25° C., of the following nuclear methylated styrenes have been measured: ... These values are approximately corrected for atom polarization. Otto and Wenzke1 report a value of 0.63 D for (I). The others appear not to have been ...
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  • 10
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1.Calliactis polypus in Hawaii and C. tricolor in Puerto Rico both respond to mechanical stimuli that resemble the activities of their commensal pagurids, e.g., stroking, tapping, scratching and squeezing of the column, by opening up, relaxing and loosening their pedal discs (Figs. 3–6). 2.C. polypus, which does not transfer to crabs unaided, could only be detached by lifting the pedal disc after the anemone had been subjected for some time to tactile stimuli very similar to those applied by Dardanus gemmatus (Figs. 1 and 2). C. tricolor, which can transfer to shells unaided by crabs and which lives on several hosts, can be relaxed and detached quickly by various substitutes, the most effective being gentle brushing around the base (Figs. 7–10). 3.Both species of Calliactis, when detached by such substitutes, were expanded and relaxed and retraction responses were inhibited. In this state tentacles and pedal discs adhered strongly to any solid surface and the anemones settled on these quickly (Figs. 11–14). 4.Electrical stimuli at low frequencies (maximum 1 pulse per sec at 27–29° C) cause extension and relaxation of the column. Usually after 40–50 stimuli release of the pedal disc occurs. The effective pulse frequencies are close to the frequency of the tactile contacts of crabs or substitutes which evoke the relaxation and release of C. polypus and C. tricolor (Figs. 15–18). 5.It is suggested that species with less restricted host relationships, in this case C. tricolor, are less restricted also in the kinds of stimuli that cause detachment. The role of sensory adaptation and the requirements of the neural organization controlling these activities are discussed. The excitation process is frequency-dependent and the response pattern is triggered at an appropriate level by summation. the detachment of C. polypus and C. tricolor is compared with the very slow detachment of C. parasitica in response to shells, and with the very rapid detachment of the swimming sea anemones, Stomphia and Actinostola. All of these anemones use different mechanisms to achieve the same end.
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