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  • Articles  (52)
  • Springer  (36)
  • American Institute of Physics (AIP)  (8)
  • Elsevier  (8)
  • 1
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1046-5928
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: Atrial natriuretic factor (ANF) ; platelet aggregation ; aldosterone ; whole blood ; ex-vivo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol·kg−1.min−1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6–2 μg·ml−1)-induced or ADP (0.5–2.0 μM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperreactivity, often observed in these conditions.
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  • 5
    ISSN: 1432-1041
    Keywords: Atrial natriuretic factor ; Cyclosporin A ; heart transplantation ; renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The mechanism(s) causing high levels of plasma atrial natriuretic factor (ANF) in cardiac allograft recipients is(are) unclear. The kidney is important for the clearance of ANF and renal function may decline with cyclosporin A therapy in these patients. The relationship between plasma ANF level and renal function and also the pharmacokinetics of a continuous infusion of ANF (15.5 ng·kg−1·min−1 for 60 min) was examined in 6 cardiac allograft recipients on cyclosporin A therapy. Resting plasma ANF levels were significantly higher in these patients than in 8 healthy subjects (71 vs. 21 ng·l−1). Both effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were significantly lower in these patients than in healthy subjects (215 vs. 617 ml·min−1 and 55 vs. 102 ml·min−1 respectively). There was a significant inverse correlation between plasma ANF and ERPF (r=-0.86) and between plasma ANF and GFR (r=-0.81). During the period of ANF infusion, steady state plasma ANF levels were significantly higher in cardiac allograft recipients. Total body clearance of ANF was marginally lower in these patients than in healthy subjects (60 vs. 10.0 l·min−1) although this difference did not reach statistical significance. Derived endogenous secretion rate of ANF was threefold higher in patients when compared to healthy subjects (633 vs. 208 ng·min−1). We have therefore shown that cardiac allograft recipients on cyclosporin A have elevated plasma ANF levels and also decreased renal function. Pharmacokinetic analysis have shown that this increase in plasma ANF levels is due more to increased ANF secretion than to decreased ANF clearance in these patients.
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  • 6
    ISSN: 1432-1041
    Keywords: Lisinopril ; Diastolic dysfunction ; congestive heart failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract This study examined the effects of lisinopril on diastolic function in 12 normotensive patients (mean age 72 years) with symptomatic congestive heart failure, intact left ventricular systolic function and abnormal diastolic function secondary to ischaemic heart disease in a placebo-controlled double blind crossover study, with each treatment dosed orally for 5 continuous weeks. Compared to placebo, lisinopril significantly decreased blood pressure, increased plasma renin activity without altering heart rate or plasma norepinephrine. There was no statistically significant improvement with lisinopril in radionuclide derived peak filling rate and time to peak filling rate, in Doppler echocardiographic measurements of the ratio of peak flow velocity in early diastole to the peak flow velocity of atrial contraction (E:A ratio) and in visual analogue scales of symptoms. Thus, although angiotension converting enzyme inhibitors may have an established role in the treatment of heart failure secondary to left ventricular systolic dysfunction, its use in patients with isolated diastolic dysfunction remains unclear.
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Morbus Parkinson ; Riechvermögen ; Riechprüfung ; Geruchsschwelle ; Olfaktorische Identifikation ; Keywords Olfactory function ; Parkinson's disease ; Odor identification ; Smelling ; Odor detection threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Olfactory dysfunction seems to be one of the most frequent symptoms in idiopathic parkinsonian syndrome (IPS). In contrast to the increasing number of studies providing evidence of the usefulness of olfactory tests in the diagnosis of IPS, clinical assessment of olfactory function is rarely performed. This may be due to the lack of an easy-to-use, inexpensive, standardized, and reliable test. In this study, we administered the newly developed “sniffin' sticks” test to a group of 40 nondemented IPS patients and compared the results with 40 healthy controls matched for age, gender, and smoking habits. In all three subtests including odor identification, odor detection threshold, and odor discrimination, the control group scored significantly better than the IPS group, yielding a specificity and sensitivity of 90% each. Our results indicate that olfactory disturbances in IPS can be found at early stages of the disease, appear bilaterally, and do not correlate with the dominant side of parkinsonism. Therefore, we emphasize that olfactory testing may be a useful tool in the diagnosis of IPS.
    Notes: Zusammenfassung Riechstörungen scheinen eines der häufigsten Symptome bei idiopathischem Parkinsonsyndrom zu sein. Obwohl in einer Reihe von Studien eine Beteiligung des olfaktorischen Systems bei Morbus Parkinson nachgewiesen wurde, werden Riechprüfungen zur klinischen Diagnostik nur selten eingesetzt. Ein Grund ist sicher die mangelnde Verfügbarkeit eines einfach anzuwendenden, ökonomischen, standardisierten und zuverlässigen Testverfahrens. In der vorliegenden Studie verwendeten wir den neuentwickelten Sniffin'-sticks-Test zur seitengetrennten Überprüfung des Geruchssinnes bei 40 Parkinsonpatienten und verglichen die Ergebnisse mit 40 Kontrollpersonen, die nach Alter, Geschlechtszugehörigkeit und Rauchgewohnheiten parallelisiert waren. In allen 3 Untertests der Geruchsprüfung, bestehend aus einer Identifikationsprüfung, Diskriminationsprüfung und Schwellenmessung, erzielte die Kontrollgruppe signifikant bessere Ergebnisse. Die Sensitivität und Spezifität des Testverfahrens betrug je 90%. Unsere Ergebnisse zeigen, dass Riechstörungen bei Morbus Parkinson bilateral und im Frühstadium der Erkrankung auftreten und dass die Überprüfung der Geruchsfunktion eine wertvolle Methode in der klinischen Diagnostik des IPS sein kann.
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  • 8
    ISSN: 1432-5233
    Keywords: Key words Experimental diabetes ; Albuminuria ; Glomerular metabolism ; ACE inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical studies indicate a nephro-protective effect in conjunction with the use of ACE inhibitors. This study's aim was to determine whether ACE inhibitors influence the metabolism of glomerular cells in addition to their known hemodynamic effects. Streptozotocin diabetic rats were treated with lisinopril (DLis 1.5 mg/l water), or hydralazine (Dhyd, 50 mg/l water) over 4 weeks. Untreated diabetic rats (DC) and non-diabetic rats (C) served as controls. After four weeks of treatment, urinary excretion of albumin, blood pressure and metabolic control (Glyc-Hb) were measured. After treatment glomeruli were isolated and homogenized, and β-NAG and total proteolytic activity against azocasein were measured. Glycated hemoglobin levels were similar in all diabetic groups (DC, 12%, Dhyd, 10%; DLis 11%). Blood pressure of DLis rats (79 ± 3 mmHg) and DHyd rats (46 ± 2 mmHg) was lower than that of DC rats (111 ± 3 mmHg). Urinary albumin excretion of diabetic groups was lowest in DLis. Diabetic rats showed a decrease in glomerular β-NAG (10 vs. 60.5 U/g protein) and total proteolytic activity against azocasein (148 vs. 170 U/mg protein hour) compared to non-diabetic rats. Lisinopril increased β-NAG (30 vs. 14 U/g protein) and total proteolytic activity (160.5 vs. 141.5 U/mg protein hour) compared with hydralazine. Our study confirms that the nephro-protective effect of ACE inhibitors is partially due to modulatory effects on the metabolism of basement membrane proteins.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Few body systems 16 (1994), S. N16 
    ISSN: 1432-5411
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Schmerztherapie ; Tumorschmerz ; Kopfschmerz ; Rückenschmerz ; Epidemiologie ; Key words Pain management ; Cancer pain ; Headache ; Back pain ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In Middle Franconia, one of the larger Bavarian administrative division (population 1994: 1,657,101), the number of patients suffering from cancer pain, chronic headache and chronic back pain is not known. Furthermore, there are no data on interdisciplinary organization of outpatient pain management. Methods: All physicians and psychologists involved in outpatient pain management in Middle Franconia (n=2130) were asked (questionnaires) to estimate the number of patients suffering from cancer pain, chronic (〉6 months) headache and chronic (〉6 months) back pain treated the last 12 months. Results: 264 (12.4%) responses were analyzed; 107,346 patients had been treated in the last 12 months, 67% by a single specialist and 33% by two or more specialists. The participation of psychotherapists and anesthetists in outpatient management of pain patients was poor; 22,754 (21%) patients were thought to need multidisciplinary algesia therapy in a pain clinic, which actually does not exist in Middle Franconia. Conclusion: The data presented suggest that patients suffering from chronic pain are not optimally managed in Middle Franconia. Regional institutions for multidisciplinary pain treatment have to be established close to where chronic pain patients live.
    Notes: Zusammenfassung Zur orientierenden Schätzung der ambulanten Versorgung von Patienten mit Tumor-, Kopf- und Rückenschmerzen im bayerischen Regierungsbezirk Mittelfranken wurden im Oktober 1995 an alle an der ambulanten Behandlung von Patienten beteiligten Ärzte und nichtärztlichen Psychotherapeuten dieser Region (n=2130) Fragebögen gesandt. 264 Kollegen (12,4%) lieferten auswertbare Angaben. Von diesen Kollegen wurden in den letzten 12 Monaten 107 346 Patienten mit chronischen Schmerzen behandelt. Davon wurden 72 255 Patienten (67%) monodisziplinär und 35 091 Patienten (33%) ambulant-interdisziplinär behandelt. Der Anteil der Psychotherapeuten und Anästhesisten an der ambulanten Diagnostik und Therapie von Schmerzpatienten war gering. Bei 22 754 Patienten (21%) wurde aufgrund der Therapieresistenz der Beschwerden unter ambulanten Bedingungen eine multidisziplinäre algesiologische Diagnostik und Therapie unter stationären oder teilstationären Bedingungen für notwendig erachtet. Derartige Einrichtungen bestehen derzeit in Mittelfranken nicht. Die Zahl problematischer Schmerzpatienten ist als Mindestzahl aufzufassen und unterstreicht die Notwendigkeit, wohnortnah adäquate schmerztherapeutische Behandlungseinrichtungen aufzubauen.
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