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  • Articles  (61)
  • Springer  (61)
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  • Articles  (61)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 18 (1860), S. 221-242 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-2218
    Keywords: Fibrin-coated collagen fleece (Tachocomb) ; Endoscopic surgery ; Tachocomb application system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Diffuse bleeding from parenchymatous organs or bleeding of the lung both in conventional and endoscopic surgery has to this day been treated with the usual methods — coagulation, tamponade, or oversewing. Methods: With the development by the pharmaceutical industry of a collagen fleece coated with fibrin glue (Tachocomb), an additional method of hemostasis became available. Results: The positive results obtained with the fibrin-coated collagen fleece in conventional surgery encouraged us to employ it when performing endoscopic operations. Especially with laparoscopic cholecystectomies, but also in other endoscopic operations, the application of Tachocomb has proved very successful. Nevertheless, the method of applying Tachocomb was not adequate, and limited its use, which made it necessary for us to develop an application system for endoscopic use. Conclusions: The application system, which consists of a fan as the Tachocomb carrier and a mounting support, worked well during the first tests. In order to confirm this, clinical studies will now be carried out.
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  • 4
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A simple procedure is described for the extraction and purification of alginate from the inner stipes of the kelp Laminaria pallida. Alginate yield was about 10–15% of the dry mass, with a 70:30 mannuronic/ guluronic acid ratio. Analysis of the purified alginate revealed a low polyphenol content while proteins were below detection level. The purified alginate was highly viscous, with 10–15 mPa s and 281 mPa s for a 0.1% and 0.5% solution, respectively, indicating a very high molecular mass (larger than 250 kDa). Bead formation occurred in the presence of divalent cations, but also in the presence of artificial serum (FCSIII) without added divalent cations. The biocompatibility of the alginate was tested with the in vitro mice lymphocyte test as well as by implantation of Ba2+ cross-linked beads beneath the kidney capsule of BB/OK rats. There was no evidence for significant mitogenic activity or fibrotic reaction. Biocompatibility of the alginate was also demonstrated by the encapsulation of human chondrocytes into Ca2+ cross-linked alginate beads. Immobilized chondrocytes grew and remained functional (i.e. they produced collagen).
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 65 (1991), S. 480-484 
    ISSN: 1432-0738
    Keywords: Chloroquine ; Retinopathy ; Retinal pigment epithelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate chloroquine retinopathy, the effect of chloroquine on the viability and differentiation of primary cell cultures of embryonic chick neuronal retina, retinal pigment epithelium (RPE), brain and meninges were investigated. The sensitivity of the cells, measured as reduction of viability, showed the following order: RPE 〉 brain 〉 meninges 〉 neuronal retina. The human serum chloroquine concentration range which leads to ocular damage in vivo was identical to the concentration range in the culture medium which affected RPE viability. In addition, the differentiation of nerve cells in brain cell cultures was affected at much lower chloroquine concentrations than astroglia cells or nerve cells in neuronal retina cell cultures. Some possible mechanisms for chloroquine retinopathy were assessed.
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  • 7
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 8
    ISSN: 1432-0711
    Keywords: Mastodynie ; Danazolbehandlung ; Hypophysenfunktion ; Schilddrüsenfunktion ; Danazol ; Pituitary function ; Thyroid function ; Mastodynia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The present study follows the clinical effect of Danazol (Winobanin) in the treatment of mastodynia in 24 patients. Ten of these patients were subjected to GnRH and TRH before and during the treatment with Danazol to study the functional reserve of the pituitary. In addition serum levels of T3, T4, and estradiol were determined. Danazol treatment was effective in 17 of the 24 patients. Basal levels of FSH and LH as well as the GnRH stimulated levels were not affected by the Danazol treatment. The average plasma levels of estradiol decreased from 87 ± 28 pg/ml to 50 ± 27 pg/ml under Danazol therapy. TRH stimulated prolactin levels were significantly lower under Danazol as compared to the pretreatment values. Basal levels of prolactin, however, remained unchanged. Basal and TRH stimulated TSH values were not affected by Danazol. T3 serum levels decreased significantly from 109.2 ± 12.6 ng/ml to 79.4 ± 9.1 ng/ml during Danazol intake. Thyroxin values remained constant. From the data obtained it can be concluded: 1. Danazol is an effective drug in treating mastodynia. 2. The antigonadotrophic effect of Danazol is obviously of minor importance. 3. The functional reserve of prolactin is reduced under Danazol probably due to a slightly suppressed ovarian function as reflected by decreased estradiol serum levels. 4. In patients under Danazol hypothyreoidism may be simulated by reduced T3 levels.
    Notes: Zusammenfassung Die vorliegende Studie untersucht die klinische Wirksamkeit von Danazol (Winobanin) bei der Behandlung von 24 Patientinnen mit Mastodynie. Bei zehn dieser Patientinnen wurde der Einfluß von Danazol auf die funktionelle Reserve der Hypophysenhormone LH und FSH nach GnRH-Stimulation untersucht, ebenso Prolaktin und TSH vor und nach Injektion von 0,2 mg TRH. Zusätzlich wurden die Plasmaöstradiolspiegel sowie Thyroxin und Trijodthyronin bestimmt. Einundsiebzig Prozent der Patientinnen wurden unter der Danazolbehandlung beschwerdefrei, während die Placebogabe nur in 21% zur Beschwerdefreiheit führte. Die basalen sowie GnRH-stimulierten LH- und FSH-Spiegel sanken nicht signifikant unter der Danazolbehandlung. Die Östradiolplasmaspiegel lagen vor der Behandlung bei 87 ± 28 pg/ml und fielen unter Danazol auf 50 ± 27 pg/ml (p 〈 0,01). Die TRH-stimulierten PRL-Antworten waren unter Danazol signifikant gesenkt, während die basalen PRL-Spiegel unbeeinflußt blieben. Die TSH-Sekretion wurde durch die Danazoleinnahme nicht verändert. Die Trijodthyroninspiegel sanken von ausgangs 109,2 ± 12,6 ng/ml auf 79,4 ± 9,1 ng/ml unter der Behandlung (p 〈 0,01). Die Thyroxinwerte blieben unbeeinflußt. Aus diesen Ergebnissen kann folgendes geschlossen werden: 1. Danazol ist ein Medikament, das erfolgreich in der Mastodyniebehandlung eingesetzt werden kann. 2. Die antigonadotrope Wirkung von Danazol ist gering ausgeprägt. 3. Die hypophysäre Prolaktinreserve ist unter Danazol vermindert. 4. Bei den behandelten Patienten wird durch den erniedrigten T3-Spiegel eine Hypothyreose vorgetäuscht.
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  • 9
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Untersuchungen über die Beeinflussung der Capillarpermeabilität der Augen- und Endometriumgefäße durch die weiblichen Sexual-hormone ergaben: 1. Unter physiologischen Bedingungen besteht kein Einfluß auf die Augengefäße. 2. Hohe Dosen von Follikelhormon führen zu einer Permeabilitätssteigerung der Augengefäße, höchste Dosen von Follikelhormon und Gelbkörperhormon zu einer Permeabilitätsherabsetzung. 3. Nach Follikel- und Gelbkörperhormon kommt es am Endometrium, das in die Augenvorderkammer von Kaninchen implantiert wurde, zu einer ausgeprägten Permeabilitätserhöhung seiner Gefäße. Follikelhormon und Progesteron potenzieren sich dabei in ihrer Wirkung. 4. Die Wirkungen des Progesterons klingen schneller ab als die des Follikelhormons. Theoretische und klinische Folgerungen, die sich aus den Versuchen ergaben, wurden diskutiert. Außerdem wurde ein Beitrag zur Klärung des sog. „blushing-blunching-phenomen“, von Endometriumtransplantaten in der Augenvorderkammer geleistet.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 104 (1937), S. 309-334 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Betrachtet man die Versuche mid die ausgeführten theoretischen Betrachtungen nochmals zusammen, so sieht man, daß die Ergebnisse der Versuche durch die gegebene Theorie, trotz aller dabei vernachlässigten Feinheiten, die bei einem solchen Eutladungsvorgang noch auftreten, gut erklärt werden, da die theoretischen Betrachtungen, die man in die vier Gleichungen $$\begin{gathered} n_e = n_{e_{max} } \cdot e - \varrho ^2 /2C (Gleichung 6) \hfill \\ n_ + = n_ - = \sqrt {\frac{{bn_e }}{\alpha }} (Gleichung 7) \hfill \\ D = C_1 /p (Gleichung 8) \hfill \\ z = C_2 \cdot i_E \cdot p^2 (Gleichung 9) \hfill \\ \end{gathered} $$ zusammenfassen kanu, zuni inindesten für die ]., 3. und 4. Gleichung von den durchgeführten Messungen bestätigt werden. Zur guten Bestätigung der 2. Gleichung konnte nicht das nötige Zahlenmaterial erhalten werden. Immerhin deuten die erhaltenen Zahlen auch auf eine Bestätigung dieser Gleichung hin.
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