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  • 1
    ISSN: 1433-2965
    Keywords: Key words:Adolescents – BUA – Children – Puberty – SOS – Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We investigated the quantitative ultrasound (QUS) parameters broadband ultrasound attenuation (BUA) and speed of sound (SOS) measured in the posterior part of the calcaneus at the region of interest (ROI) with the lowest attenuation, using an ultrasound imaging device (UBIS 3000) in 491 healthy Caucasian children and adolescents (262 girls, 229 boys) between 6 and 21 years old. The relation of age, body weight, height, foot dimensions and pubertal stage to BUA and SOS was assessed. BUA increased nonlinearly with age in boys and girls, r 2 being 0.44 (p〈0.001) and 0.57 (p〈0.001), respectively. SOS increased linearly with age in girls (r 2= 0.04, p〈0.001). There was no significant increase in SOS in boys (r 2= 0.01, p〉0.05). Heel width was significantly correlated with BUA (r= 0.20, p〈0.005 in boys; r= 0.27, p〈0.05 in girls) and with SOS (r=−0.19, p〈0.005 in boys; r=−0.08, p〈0.05 in girls). After downward adjustment of the ROI size according to foot length quartiles, significantly lower BUA and SOS values were found compared with those with the standard ROI size of 14 mm. After correction for heel width and adjustment of the ROI size based on foot length, BUA and SOS were significantly associated with age in boys (r 2= 0.36, p〈0.001 and 0.06, p〈0.05) and in girls (r 2= 0.53 and 0.06, both p〈0.001). Tanner stage was significantly correlated with BUA (r= 0.62, p〈0.001 in boys; r= 0.73, p〈0.001 in girls) but not with SOS. BUA but not SOS increased significantly with the number of years since menarche (p〈0.001). In a multiple stepwise regression analysis in boys, age, weight and foot length were independent predictors for BUA, and age and foot length for SOS. In girls, age and weight were independent predictors for BUA and age was the only independent predictor for SOS. After correction for age, pubertal stages and heel width were no longer determinants for QUS parameters in either boys or girls. In conclusion, BUA increased significantly with age in both sexes. SOS increased with age in both boys and girls, but the increase was small and not statistically significant in boys. SOS, as measured with the UBIS 3000 device, may therefore not be appropriate to assess skeletal status in healthy children. Whether SOS and BUA are affected in children with skeletal disorders has yet to be determined. In boys, age, weight and foot length were independent predictors for BUA and age and foot length for SOS. In girls, age and weight were independent predictors for BUA and age was the only independent predictor for SOS. In our opinion, children with small feet should be measured with a smaller ROI diameter than those with larger feet.
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  • 2
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case with an intense accumulation of 57Co-bleomycin in lymph node metastases of malignant melanoma in the mediastinum as a casual finding is reported. The patient had undergone a 57Co-bleomycin scintigraphy because of a peripheral lesion on the chest X-ray, in which a pathological diagnosis was impossible to obtain. This lesion showed no uptake of the radiopharmaceutical.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 26 (1977), S. 385-405 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Eliashberg has predicted that absorption of microwaves in a superconducting film leads to an increase of the energy gap by creating a nonequilibrium quasiparticle distribution. The frequency has to exceed the inverse relaxation time for inelastic scattering. In the present paper measurements are reported of the critical current of long, narrow, superconducting thin-film strips of aluminum subjected to high-frequency radiation (10 MHz–10 GHz). Above a critical frequency of about 200 MHz considerable enhancement of critical current and critical temperature is observed. Analysis of the results is performed by taking the critical current for a measure of the energy gap. The results are in reasonable agreement with Eliashberg's theory. As predicted, the transition between the superconducting and the normal states becomes of first order. The experimental results on critical current enhancement of micro-bridges (Dayem-Wyatt effect) can be explained consistently with gap enhancement.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 3 (1981), S. 1414-1417 
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Samenvatting Beschreven wordt een distributiemethode ten behoeve van cytostatica waarbij de ziekenhuisapotheek een centrale plaats inneemt. Volgens het beschreven model ontvangen wekelijks gemiddeld 10–12 patiënten hun cytostatica. Hoewel, zoals bij alle regelingen, ook hier problemen voorkomen (bijv. de patiënt komt niet opdagen, het recept blijkt niet geschreven of is zoekgeraakt tussen de meestal talrijke papieren van de patiënt, de communicatie tussen polikliniek-afdeling-apotheek is niet goed geweest) kan toch worden gesteld dat voor de betrokkenen (artsen, verpleegkundigen, apotheekpersoneel en patiënten) deze gang van zaken tot ieders tevredenheid verloopt.
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  • 5
    ISSN: 1432-1254
    Keywords: Schistocerca gregaria ; Take-off activity ; Meteorological condition ; Cold front ; Atmospheric pressure ; VLF radiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Take-off activity of the desert locust,Schistocerca gregaria (Forsk.), phasegregaria, was studied in a temperature-controlled laboratory environment and possible relationships with certain meteorological factors were analysed. A statistically significant relationship between the passage of cold fronts and an increased take-off rate was found. The reaction of the locusts could not be correlated to changes in VLF electromagnetic radiation or to the atmospheric pressure.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 23 (1979), S. 195-204 
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The paper discusses insect activity, especially take-off activity in locusts, in relation to weather disturbances. A hypothesis is presented suggesting that atmospheric electromagnetic radiation in the VLF range acts as a take-off stimulus in locusts. A method of recording the spontaneous take-off rate in locusts is described, and two observation series onSchistocerca gregaria are discussed.
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  • 7
    ISSN: 1432-2161
    Keywords: Key words Skeletal metastases ; PET ; Fluoride ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. To characterise the uptake of 18F in skeletal metastases from breast cancer using positron emission tomography (PET) and to relate these findings to the appearance on CT. Patients and design. PET with 18F and CT were performed in five patients with multiple skeletal metastases from breast cancer. The CT characteristics were analysed in areas with high uptake on the PET study. Dynamic PET imaging of the skeletal kinetics of the 18F-fluoride ion were included. Results. The areas of abnormal high accumulation of 18F correlated well with the pathological appearance on CT. Lytic as well as sclerotic lesions had markedly higher uptake than normal bone, with a 5–10 times higher transport rate constant for trapping of the tracer in the metastatic lesions than in normal bone. Conclusion. PET with 18F-fluoride demonstrates very high uptake in lytic and sclerotic breast cancer metastases.
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  • 8
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Dosierungsschemata 1 und 2 g Cefodizim intramuskulär wurden bei 287 Patienten untersucht, die wegen akuter purulenter Exazerbationen chronischer Bronchitiden stationär behandelt wurden, und bei denen überwiegendHaemophilus influenzae, Streptococcus pneumoniae undMoraxella catarrhalis isoliert wurden. Pharmakokinetische Untersuchungen in Serum und Sputum ergaben am ersten Behandlungstag durchschnittliche Maximalkonzentrationen von 50 bzw. 100 mg/l im Serum und von 1,4 bzw 2,7 mg/l im Sputum nach den oben genannten Dosierungen. Unter den unterschiedlichen Dosierungen konnten keine nennenswerten Unterschiede bezüglich der klinischen und mikrobiologischen Ergebnisse gefunden werden, mit höheren Dosierungen wurden keine besseren Ergebnisse erzielt. Bei 90–95% der Patienten konnten die isolierten Erreger während der Behandlung eliminiert werden, bei 70–80% wurden auch eine Woche nach Abschluß der Behandlung keine Erreger isoliert. In einigen Fällen konnten β-lactamase-produzierendeM. catarrhalis nicht oder nur vorübergehend eliminiert werden. Unerwünschte Arzneimittelwirkungen wurden bei 5 Patienten dokumentiert und führten in zwei Fällen zum Abbruch der Behandlung. Schlußfolgerung: 1 g Cefodizim intramuskulär 1 x täglich über 7 Tage ist eine adäquate Behandlung für die meisten Patienten.
    Notes: Summary 1 or 2 g doses of cefodizime i.m. were studied in 287 patients admitted to hospital with acute purulent exacerbations of chronic bronchitis, mostly associated withHaemophilus influenzae, Streptococcus pneumoniae orMoraxella catarrhalis. Pharmacokinetic studies in serum and sputum on the first treatment day yielded mean peak serum concentrations of 50 to 100 mg/l, with corresponding sputum concentrations of 1.4 and 2.7 mg/l, after the two respective doses. No great differences were found between the clinical and microbiological results in the various dosage groups, and no corresponding improvement was noted with the highest dosages studied. In general, infection was eliminated in 90 to 95% of patients at the end of treatment, and in approximately 70 to 80% after a follow-up week. Some infections associated with β-lactamase producingM. catarrhalis persisted or relapsed after treatment. Unwanted drug effects were recorded in five patients, leading to discontinuation in two. It is concluded that a single daily intramuscular dose of 1 g cefodizime for seven days produces satisfactory results in most patients.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of oncology 8 (1997), S. 109-110 
    ISSN: 1569-8041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 10
    ISSN: 1569-8041
    Keywords: breast cancer ; conservative treatment ; local recurrence ; risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Risk factors for local recurrence after breast-conservingtreatment of early breast cancer have not previously been evaluated insettings where mammography has been a major pathway to diagnosis of bothprimary tumour and recurrences, or in patients treated surgically by a formalsector resection. Patients and methods: Three hundred eighty-one women with stage Iprimary breast cancer were randomised after a standardised sector resectionto either a course of postoperative radiotherapy to 54 Gy to the breast (XRTgroup) or to surgery alone (non XRT group). At five years, 43 localrecurrences, six of them in the XRT group, appeared. Patient characteristicscollected from the medical records, histopathological characteristicsdetermined by re-examination of slides, and mammographic characteristcs fromthe pre-operative mammograms were evaluated as risk factors for recurrence byunivariate and multivariate Cox proportional hazards models. Results arereported as relative hazards (RH) with 95% confidence intervals(95% CI). Results: In the univariate analysis comedo cancer, RH 3.5 (95%CI 1.8–6.7), lobular cancers RH 2.8 (95% CI 1.1–7.1),mammographic appearance as circular/oval shaped density, RH 2.3 (95%CI 1.1–4.5), and mammographic appearance as a stellate lesion withmicrocalcifications inside the lesion, RH 3.8 (95% CI 1.1–13.0)were identified as risk factors for local recurrence. Age, with a RH of 0.97(95% CI 0.94–0.99) for each increasing year was inverselyassociated with risk. A multivariate analysis, which also took postoperativeradiotherapy into account, only showed comedo cancers with a RH 2.6(95% CI 1.3–5.0) and mammographic appearance of a stellate lesionwith microcalcification inside the lesion RH 4.5 (95% CI1.1–17.6) to be statistically significant. The estimates for age RH 0.98(95% CI 0.95–1.0) and lobular cancers RH 2.5 (95% CI0.98–6.6) were marginally changed, with widened CIs. Patients 〉 60years of age, without comedo or lobular carcinomas were found to be at lowrisk (5.9% at five years in Kaplan–Meyer estimate) of localrecurrence, even without postoperative radiotherapy. Conclusion: Low age, comedo and lobular cancers and mammographicappearance of the tumour as a stellate lesion with microcalcifications insidethe lesion indicate an increased risk for local recurrence after sectorresection in stage I tumours at five years. Patients 〉60 years of agewithout comedo or lobular cancers are at low risk for local recurrence at fiveyears even without postoperative radiotherapy.
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