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  • 1
    ISSN: 1619-7089
    Keywords: RIA ; Hormones ; CSF ; Blood-brain barrier ; Brain-CSF barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radioimmunoassay determinations of the levels of total T3, total T4, TSH, and prolactin in the CSF were performed on samples taken from 36 healthy individuals. The obtained reference values are the first of their kind. It is considered that RIA determinations of CSF hormone levels may provide a sensitive method for demonstrating pathological leakage through the blood-brain and brain-CSF barriers.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 4 (1971), S. 33-33 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7489
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In this article we describe the importance of reusing software artifacts resulting from the earliest stages of the development life-;cycle, i.e., software conception, requirements analysis, feasibility study, requirements specification, architectural and detailed design. Although reuse of early artifacts is deemed beneficial to software development projects, there are no readily available software tools that could facilitate their effective reuse. Hence, we identified nearly one hundred early artifact types. We analyzed, compared and contrasted them. We clustered similar artifact types into distinct artifact affinity groups. We then proposed several methods and techniques useful in the processing of these artifacts to support their reuse. We believe that the proposed methods could be utilized by tool builders to construct software development environments capable of assisting analysts, designers, architects and programmers to effectively reuse the results of early life-;cycle activities.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Computers and the humanities 6 (1972), S. 131-136 
    ISSN: 1572-8412
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Media Resources and Communication Sciences, Journalism
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-6903
    Keywords: Diabetes ; protein ; microvessel ; blood-brain-barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine the effect of diabetes mellitus on cerebral microvessel protein composition, post translational modification of proteins with glucose and malondialdehyde (MDA) was determined and the abundant protein species found in cerebral microvessels isolated from control and streptozotocin-induced diabetic rats were studied. Two dimensional gel electrophoresis and computer assisted densitometry revealed that only one out of 25 quantitated proteins was significantly altered in diabetic rats after 5 weeks of uncontrolled hyperglycemia. The level of glycosylation of cerebral microvessel protein mixture was significantly increased in diabetic rats compared to control rats (168.8±25 vs 109.5±4.8 nmol/mg) (p〈0.05). Western blot analysis of cerebral microvessel proteins from diabetic rats using a specific antibody against MDA-modified proteins revealed three protein spots with molecular weights of approximately 60,000 Kd. These were shown not to be contaminants from cerebral tissue or plasma proteins modified with MDA. It is concluded that short duration of streptozotocin-induced diabetes mellitus in rats is associated with some qualitative changes in protein composition of cerebral microvessels. These changes may contribute to the diabetes-related alterations in the blood-brain barrier.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 83 (1917), S. 467-488 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Two theoretical models for the division of droplets in a turbulent flow were experimentally checked for high viscous liquids. The relationships found between the polymer beads maximum diameters and the aqueous phase viscosity cannot be described by an inertial breakup but are in good agreement with a viscous shear breakup.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    AI & society 6 (1992), S. 62-77 
    ISSN: 1435-5655
    Keywords: Human-computer interface ; Information transfer ; Communication ; Linguistics ; Speech acts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract When people speak about “communication barriers”, what they usually think about are such things as the limitations set by human nature itself, or the constraints that are inherent in the tools we use for communicating. As an example of the first, consider the limited range of the naked human voice; for the second, we may think of the limitations imposed by such primitive communicative devices as the bonfire, the heliograph, or an old-fashioned megaphone. Our contribution draws attention to the fact that, despite enormous advances on the technological side of human communication (such as demonstrated by the existence and use of computers as communication devices), there still are some barriers to be removed as far as the human side is concerned. We call these barriers the “stumble-blocks of the mind”. Their existence is demonstrated by the study of two case stories, which show that understanding the communicative implications of computerizing information is more important than increased emphasis on ever fancier and more expensive hardware products. The next question has to do with the reasons for these “stumbling blocks” to occur. Current communicative and linguistic theoretical findings are used in an effort to explain and solve the communicative dilemmas that are encountered in the organization of our communication, among others in the area of human-computer interface. In particular, the notion of “privacy” in speech acting is suggested as an overlooked aspect, and the notion of “information transfer” is replaced by that of “creating mental activity”. Finally, some conclusions are drawn, and a number of practical applications are offered.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    AI & society 10 (1996), S. 226-232 
    ISSN: 1435-5655
    Keywords: Technology ; Cognition ; Computers ; Language ; Pragmatics ; Mind and Brain ; Tool ; Leaf-blower
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Technology, in order to be human, needs to be informed by a reflection on what it is to be a tool in ways appropriate to humans. This involves both an instrumental, appropriating aspect (‘I use this tool’) and a limiting, appropriated one (‘The tool uses me’). Cognitive Technology focuses on the ways the computer tool is used, and uses us. Using the tool on the world changes the way we think about the world, and the way the world appears to us: as an example, a simple technology (the leaf blower) and its effects on the human are discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    AI & society 10 (1996), S. 233-258 
    ISSN: 1435-5655
    Keywords: Cognitive adaptation ; Cognitive Technology ; Information Superhighway ; Metaphor ; Pragmatic act ; Relevance analysis ; World Wide Web
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In this paper, we explore some characteristics of the Information Superhighway and the World Wide Web metaphors in the light of the current developments in information technology. We propose that these characteristics constitute a form of conceptual slippage (often in the form of ‘lexical leakage’), which helps us detect and predict the tacit impact that the currently available information delivery systems are having on human cognition. We argue that the particular language associated with these systems evolves as a direct result of human cognitive adaptation to the demands, resources, and constraints of highly technological environments. It reflects a growing alienation of the users of computerized systems from the physical aspects of the natural environment in which the disseminated information was originally grounded. We believe that a careful investigation of the pragmatic phenomena which are operative when the information media jargon is used is appropriate to the aims of Cognitive Technology. The role of metaphor as a vehicle for self-expression, as mediated by criteria of relevance, is discussed from this perspective.
    Type of Medium: Electronic Resource
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