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  • 1
    ISSN: 1433-2965
    Keywords: Key words: Anthropometry – Caucasian women – Dietary calcium intake – Family history of osteoporosis – Physical activity – Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This study aimed to assess the factors that may influence the distribution and description of broadband ultrasound attenuation (BUA) and to identify specific criteria for diagnostic consideration when collecting BUA reference data. Two hundred Caucasian women (aged 20–79 years) without a history of atraumatic fractures or medicines known to affect bone metabolism were selected for this study. Medical and menstrual history, medication usage, family history of osteoporosis (FHO), physical activity, activities of daily living (ADL), dietary calcium intake, as well as smoking and alcohol consumption were obtained. Broadband ultrasound attenuation (BUA, dB/MHz) was determined in the right foot using a new gel-coupled ultrasound system. BUA was significantly associated with age (p〈0.001), body weight (p〈0.001), level of physical activity (p = 0.024) and dietary calcium intake (p= 0.023). Smoking, alcohol and coffee consumption and ADL were not associated with BUA (p〉0.05). There were no differences in BUA (p〉0.05) between those women who reported taking medications or had diseases (known to not affect bone metabolism), were using contraceptives, taking vitamin/mineral supplements and/or had traumatic fractures and their counterparts who did not report these characteristics. Premenopausal women with a FHO had significantly lower BUA values compared with those without a FHO (p= 0.013). When those participants with a FHO were removed from the sample, the peak BUA value was 1.1–4.4% higher and the variability (SD) was reduced by about 3.3–9.3% depending on which age range was used to define the peak BUA value. Consequently, an additional 4.5% of the population were classified as having a T-score 〈−2. Our results suggest that the impact on BUA of risk factors such as a FHO, body weight, physical activity and dietary calcium intake is similar to that on bone mineral density obtained by dual-energy X-ray absorptiometry (DXA), and thus provides further information on the comparability of quantitative ultrasound and DXA for assessment of risk of fracture. The criteria for calculating the T-score need further study to determine whether young adults with FHO should be included and what cutoff age range should be used in collecting peak values of quantitative ultrasound parameters.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: Key words Paired-related homeobox ; Heart development ; Pharyngeal arch arteries ; Vascular matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Prx1 (MHox) and Prx2 (S8) are non-clustered homeobox genes that are expressed in a complex, mostly mesenchyme-specific pattern throughout embryogenesis. The expression pattern and gene-targeted mice previously revealed a major role for Prx1 in skeletogenesis. In addition, specific and high expression of both Prx genes was reported in the developing cardiovascular system, predominantly in prospective connective tissues of the heart and in the great arteries and veins. We examined embryos of previously generated gene-targeted mice. Prx2-/- mutants were viable and did not show cardiovascular malformations. Intracardiac morphology of Prxl-/- and Prx1/Prx2-combined null mutants also appeared normal throughout development. However, the Prx1-/- and Prx1/Prx2 double-null mutants showed a vascular abnormality with an abnormal positioning and awkward curvature of the aortic arch in addition to a misdirected and elongated ductus arteriosus, and in two of seven combined mutants, an anomalous retro-oesophageal right subclavian artery. Generally, all great arteries appeared to run somewhat tortuously through the surrounding mesenchyme. The vascular histology and vessel wall thickness were normal in all mutants. Prx1-/- and Prx double-gene-targeted mice revealed similar spectra of vascular anomalies, but double mutants appeared to be more seriously affected. The current findings suggest that other genes may compensate for the lossof Prx in the heart, but, in contrast, our data support a role for Prx in the development of vascular and perivascular matrix.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1436-3771
    Keywords: Key words Clasp-retained dentures ; Conical crown-retained dentures ; Removable partial dentures ; Long-term results ; Clinical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this retrospective study was to examine the condition and success rate of various designs of removable partial dentures 10 years after placement. Seventy-four patients treated with 101 mainly conical crown-retained dentures (CCRDs), clasp-retained removable partial dentures (RPDs), or a combination of conical crown and clasp-retained dentures (CRPDs) were reexamined. Prosthetic findings were compared to baseline values at insertion and checked for factors that may affect them. Overall, 36.6% of the prostheses were regarded as successes, 23.8% as partial successes, and 39.6% as failures. Also, only one-third of the prostheses showed neither hygienic problems nor technical failures. The statistical analysis identified no single parameter as significantly affecting the success rate of the partial dentures. Prostheses supported by several abutment teeth had improved success, and RPDs had a higher failure rate (66.7%) than CCRDs (33.3%) and CRPDs (44.8%); however, because of the limited number of RPDs these differences were not statistically significant. Although the prostheses were unsupervised in service, the 60.4% overall success rate of the dentures was somewhat higher than in other studies on precision-retained prostheses.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-2451
    Keywords: Supination trauma of the ankle joint ; Inveterate rupture of the lateral ligament ; Delayed ligamentous reconstruction ; Sprunggelenksdistorsion ; Veraltete fibulare Bandruptur ; Außenbandplastik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2944 Supinationstraumen im oberen Sprunggelenk konnte 629mal eine fibulare Bandinstabilität nachgewiesen werden. In 35 Fällen (= 5,5%) handelte es sich um eine veraltete Außenbandruptur, 24mal mit einem erneuten Supinationstrauma. 74% dieser Patienten waren unter der falschen Erstdiagnose „Distorsion” konservativ behandelt worden. In 45% konnte radiologisch eine Arthrose nachgewiesen werden, in 1/3 aller Fälle wurden durch das erneute Trauma primär nicht vorgeschädigte Bandstrukturen verletzt. Die Nachuntersuchungsergebnisse waren nach sekundärer Bandplastik mit 42,9 % beschwerdefreien und 52,4 % zufriedenen Patienten schlechter als nach primärer Bandnaht mit 90,5 % beschwerdefreien und 3,6 % zufriedenen Patienten.
    Notes: Summary In 2944 cases of supination trauma of the ankle joint, fibular ligamentous instability could be identified 629 times. In 35 cases (5.5%) we found an inveterate rupture of the lateral ligament, of which 24 followed a recurring supination trauma. The false primary diagnosis “distortion” had led to 74% of these patients being treated conservatively. In 45 % an arthrosis could be seen radiologically, in 1/3 previously intact ligamentous structures had been damaged by the renewed trauma. The results of the follow-up examination were poor after delayed reconstruction of the ligament, with 42.9 % of patients asymptomatic and 52.4 % satisfied, compared with 90.5 % and 3.6 % after primary repair of the ligament.
    Type of Medium: Electronic Resource
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