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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We describe a new familial syndrome in three siblings; it is biochemically characterized by a combined defect of the action of the three related peptides insulin, insulin-like growth factor I (IGF I) and epidermal growth factor (EGF). Clinically, the disease has features of Werner syndrome with lipodystrophy, scleroderma-like alterations of the skin, alterations of the skeleton and contractures of joints. In addition, one of the patients has an insulin-resistant diabetes mellitus. Studies with cultured fibroblasts obtained from skin biopsies show a markedly reduced stimulation of RNA synthesis by the three growth factors and a decreased insulin stimulation of 2-deoxy-d-glucose uptake as compared with normal controls. Receptor binding of the three peptides occurred with normal capcity and affinity. We conclude that the signal transfer of different growth factors has a common denominator at the postreceptor level.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Keywords: Key words: OP-1 — TGF-β— Fibronectin fragments — Cartilage — Cartilage repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: The abilities of osteogenic protein-1 (OP-1) and TGF-β1 to affect cartilage damage caused by fibronectin fragments (Fn-fs) that are known to greatly enhance cartilage proteoglycan (PG) degradation were compared.¶Material: Articular cartilage was obtained from 18 month old bovines.¶Treatment: To test blocking of damage, cartilage was cultured with or without OP-1 or TGF-β in the presence of 100 nM Fn-fs. To test restoration of PG, cartilage was first cultured with Fn-fs and the cartilage then treated with factors.¶Methods: Cartilage PG content was measured in papain digests using the dimethylmethylene blue assay. PG synthesis was measured by incorporation of 35S labeled sulfate.¶Results: OP-1 blocked damage and restored PG in damaged cartilage, apparently due to enhanced PG synthesis. However, TGF-β1 alone decreased PG content.¶Conclusions: These results clearly demonstrate differences between OP-1 and TGF-β1, both members of the TGF-β superfamily and illustrate the efficacy of OP-1 in blocking Fn-f mediated damage.
    Type of Medium: Electronic Resource
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