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  • 1
    ISSN: 1432-1041
    Keywords: Key words Mibefradil ; Low-density lipoprotein oxidation ; Calcium channel blocker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Mibefradil is a novel calcium channel antagonist that selectively blocks T-channels. It acts to reduce hypertension, is cardioprotective and reduces ischemic episodes. Oxidative modification of low-density lipoproteins (LDL) is well known to contribute to coronary atherosclerosis and we therefore investigated to see whether mibefradil had antioxidative action on LDL. Methods: Human LDL were isolated by ultracentrifugation. In vitro oxidation of LDL (0.1 μmol · l−1 protein) in the presence of various concentrations of mibefradil was initiated by 3.2 μmol · l−1 copper ions. The kinetics of formation of conjugated dienes was followed photometrically. Malondialdehyde and lipoperoxides were determined at maximum oxidation. LDL (0.3 μmol · l−1) were also pre-incubated with mibefradil (120 μmol · l−1). Excessive mibefradil was separated by column technique. The resultant LDL were oxidized using copper ions or (AAPH) 2,2′-azobis(2-amidinopropane) hydrochloride. Results: The presence of mibefradil in the concentration range from 10 to 200 μmol · l−1 had dose-dependent effects. These were protection of LDL against oxidation measured as prolongation of the lagtime up to 250%, and reduction in the formation of malondialdehyde down to 65% and of lipoperoxides to 20%. Pre-incubation of LDL with mibefradil prolonged the lagtime of Cu-mediated oxidation up to 132% and of AAPH-mediated oxidation up to 138%. Conclusion: In addition to the T-channel blocking and antiproliferative effects, our results provide arguments for a protective role of mibefradil (10–200 μmol · l−1) on LDL against in vitro oxidation. This was shown with three independent parameters (lagtime, malondialdehyde and lipoperoxides) and in different oxidation models.
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  • 2
    ISSN: 1432-1084
    Keywords: Extramedullary Hematopoiesis ; Thalassemia ; Spine ; Liver ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 17 year old Iranian girl presented with thalassemia major, complicated by acute compression of the cauda equina caused by extramedullary haemopoiesis. The advantages of MRI in confirming the spinal space-occupying lesion and involvement of liver and pancreas are discussed in the context of treatment decision analysis and follow-up.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 21 (1995), S. 352-355 
    ISSN: 1432-1238
    Keywords: Liver ; Metastasis ; Splanchnic ; Oxygen consumption ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastatic liver disease can modify the metabolic response to critical illness. Systemic lactic acidosis may arise from an increased production due to inadequate peripheral tissue oxygen transport, altered metabolic function such as depressed pyruvate oxidation or insufficient hepatic clearing capacity due to tumor replacement of functional liver mass. Hepatic venous catheterization in a patient with extensive metastatic melanoma to the liver and adult respiratory distress syndrome indicated a marked disparity between whole body and liver oxygenation which may arise due to a markedly stepped up splanchnic oxygen utilization unmatched by a proportionate rise in regional oxygen delivery. Since some neoplasms may exhibit increased metabolic activity, it is suspected that these metastatic lesions may have contributed to the observed regional hypermetabolism thereby worsening hepatic hypoxia and exacerbating lactic acidosis. This case also illustrates the difficulties in interpreting global indicators of metabolic function and oxygenation in critically ill patients.
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  • 4
    ISSN: 1432-1076
    Keywords: Turner syndrome ; Body proportions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The body proportions in 191 individuals with Turner syndrome (TS) were investigated. At 3 years of age the mean sitting height in TS was normal, thereafter trunk growth was impaired, resulting in a standard deviation score (SDS) of −2.4 in the adult. From 3 to 12 years of age the mean SDS of leg length increased from −2.7 to −3.6; and then fell to −2.5. At 3 years of age the ratio of sitting height to leg length was 3.2 standard deviations (SD) above the normal mean. Thereafter the ratio slowly approached the normal percentiles. It was +0.6 SD in 15-to 18-year-old women. Thereafter it increased to 1.7 for adults with TS. Knemometric measurements in 32 individuals with TS and 32 controls revealed that in TS the upper legs were relatively shorter than the lower legs. We conclude that children with TS, and to a lesser extent adults, have a disproportionately short stature with relatively short legs whereas body proportions are almost normal in adolescents.
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  • 5
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new commercially developed cytomegalovirus (CMV)-IgM ELISA was found to be sensitive and specific when compared with sucrose gradient fractionation of Ig classes in CMV antibody-positive and negative sera. The presence of CMV IgM in patients' sera correlated with positive virus isolation from circulating mononuclear blood cells and urine. Serial examinations of patients with primary or recent CMV infection revealed a typical sequence of IgM and IgG development. The frequency of CMV isolation declined as the concentration of IgM decreased and the IgG levels increased. Since the isolation of CMV from clinical specimens is a cumbersome procedure, we suggest that the IgM ELISA could provide rapid and valuable information on the presence of an active or reactivated CMV infection.
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  • 6
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 7
    ISSN: 1432-069X
    Keywords: Serum concentration ; Volunteers ; Scabies-infested ; Lindane therapy ; Serum threshold concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary the kinetics of lindane concentration in the serum and the timedependant urinary excretion of two groups, one with healthy subjects and one with scabies-infested subjects, were comparatively analyzed by gas chromatography. Both groups showed similar cumulative excretion curves at completely different lindane concentrations in the serum. Comparison of serum concentration in healthy females (high lindane concentration in serum) and healthy males (low serum concentration) to the urinary excretion showed similar results. There appears to be a serum ‘threshold concentration’, above which it is possible that lindane is no longer primarily excreted by the kidney. Based on these results recommendations are presented, for the practical use of such data in the treatment of scabies.
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  • 8
    ISSN: 1432-069X
    Keywords: Elimination of “poison” ; Lindan absorption ; Scabies-therapy ; Serumconcentration of Lindan ; Serumkinetic of Lindan ; “Gift” elimination ; Lindanresorption ; Scabiestherapie ; Serumkonzentration von Lindan ; Lindankinetik im Serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach lokaler Ganzkörper-Applikation einer 0,3%igen Lindan-Emulsion bei hautgesunden Probanden und bei scabieserkrankten Patienten wurde die Konzentration von Lindan im Serum während 143 bzw. 55 h untersucht. Die Bestimmung erfolgte gaschromatographisch. Verschiedene den üblichen Therapiearten angepaßte Variationen der Behandlungsweise wurden vergleichend durchgeführt. Kriterien wie Applikationshäufigkeit, Abwaschen des applizierten Präparates mit Wasser (Duschen) unter Verwendung von Seife bzw. keiner Seife oder Vollbad ohne Seife bei Hautkranken jeweils zu verschiedenen Zeiten nach der lokalen Applikation wurden herausgearbeitet. Aus den vorliegenden Daten kann folgendes festgehalten werden: 1. Normalpersonen (im Alter von 23) einer deutschen Gro\sBstadt haben im jetzigen Zeitraum eine Lindan-Konzentration von etwa 3 ng/ml (0,003 ppm) im Blutserum. 2. Scabieskranke, die in einer Gro\sBstadt zur station\:aren Einweisung kommen, haben am Aufnahmetag einen zehnfach h\:oheren Ausgangswert (um 0,04 ppm), wahrscheinlich bedingt durch ineffektive sporadische Vorbehandlungen. Trotz dreimaliger lokaler Ganzkörperbehandlung im Abstand von 24 h sinkt das etwa 4–6 h danach auftretende Konzentrationmaximum innerhalb 3–5 h stets auf ähnliche Werte (um 10 ng/ml) ab. 3. Abduschen mit Wasser und Seife verringert bei Hautgesunden die Resorption nur, wenn dies erst l\:angere Zeit (8\2-12 h) nach der Applikation erfolgt. Kurzfristiges Abwaschen zur Verhinderung einer \ldGiftresorption\rd bewirkt das Gegenteil vom Gew\:unschten. Vollb\:ader bei Hautkranken 10 h nach der Lokalapplikation scheint die Resorption zu verst\:arken. 4. Bei nicht intaktem Integument (generalisierte excoriierte impetiginisierte Scabies) werden bei M\:annern Serumkonzentrationen von maximal 0,425 ppm gefunden. Der Extremwert bei hautgesunden M\:annern lag bei 0,0095 ppm.
    Notes: Summary A 0.3% lindane emulsion was applied to the entire body of volunteers with a healthy skin and that of scabious patients. The resulting lindane levels in the serum were followed up over periods of 143 and 55h, respectively. The lindane levels in the serum were determined with the aid of gas chromatography. A comparative evaluation of a number of modifications of therapy in accordance with the common ways of treatment was conducted using criteria, such as frequency of application, removal of the applied preparation by washing with water (shower) with and without soap, or by means of a complete bath without soap (in the case of dermatologic patients) at various times after topical application. On the basis of the data obtained, the following findings were established: 1. At present, normal persons aged 23 and living in a large German city were found to exhibit lindane levels of approximately 3 ng/ml (0.003 ppm) in their blood serum. 2. Scabious patients hospitalized in a large city had initial values on the day of their hospitalization exceeding those of normal persons by a factor of 10 (around 0.04 ppm). This has been assumed to be due to ineffective and sporadic pretreatment. Despite application of lindane to the entire body (three times at 24 h intervals), the maximal levels occurring approximately 4–6 h after application always dropped to similar values (around 10 ng/ml) within 3–5 h. 3. In volunteers with healthy skin, absorption was reduced by taking showers (and using water and soap) only if an extended period (8\2-12 h) had passed since application. Washing to prevent \ldabsorption of the poison\rd shortly after application improved absorption rather than prevented it. In dermatologic patients, complete baths taken 10 h after topical application seemed to enhance absorption. 4. Serum levels of up to 0.425 ppm were found in male patients whose integument was not intact (generalized excoriated and impetiginized scabies). In males with a healthy skin, extreme values were found to be around 0.0095 ppm.
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  • 9
    ISSN: 0942-0940
    Keywords: Intrasellar cystic craniopharyngeoma ; trans-sphenoidal approach ; intracavitary irradiation ; 90-Yttrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracavitary irradiation of intrasellar cystic craniopharyngeomas by stereotactic cyst puncture and injection of radioactive solutions is not yet possible. Therefore we designed a new method sphenoidal approach with only a small bony opening of the sella floor, followed by cyst puncture, exclusion of cyst leakage by Metrizamid injection under x-ray control, injection of Y-90-colloid solution at a dosage wich delivers a radiation of 200 Gy to the cyst wall, and finally tight closure of the puncture site using fibrin glue and gelfoam. This method has been used in three patients with good results (follow-up 12–15 months) and without complications. Even though long-term follow-up is not yet available, our preliminary results suggest that this method will be useful for future
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  • 10
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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