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  • 1
    ISSN: 1432-1076
    Keywords: Bronchial asthma ; β-Adrenoceptors ; Polymorphonuclear leukocytes ; Adrenergics ; Theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The density (Bmax) and affinity (KD) of β2-adrenoceptors in polymorphonuclear leukocytes (PMN) were measured in 29 children and juveniles with mild or moderate asthma and in 25 healthy control subjects using the highly specific radioligand (±)-125I-cyanopindolol. No significant difference in Bmax was found between asthmatic subjects without medication and the control group. The asthmatic subjects were divided into four different groups by their actual medication: no medication, adrenergics, theophylline, adrenergics plus theophylline. Analysis of variance revealed highly significant differences between these groups for Bmax (P=0.0016) but not for KD. In asthmatics on adrenergic therapy Bmax was significantly lower (995±415) than in asthmatics without medication (1660±521;P=0.008). In contrast, Bmax in asthmatics on theophylline therapy was significantly higher (2137±231;P=0.009) than in the controls. Bmax was average in the group of asthmatics treated with both adrenergics and theophylline (1619±547). It is concluded that in asthmatic subjects therapy with theophylline increases the density of β2-adrenoceptors and partly prevents their down-regulation induced by adrenergic therapy.
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  • 2
    ISSN: 1432-1076
    Keywords: Chromosomal aberration ; Ring chromosome 15 ; Dysplasias ; Malformations ; Ventricular septal defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 20-day-old female neonate was admitted with symptoms caused by a large ventricular septal defect which was subsequently confirmed angiographically. Other clinical findings were pre-and postnatal growth retardation, microcephaly, dysmorphism of ears, fingers and feet. Cytogenetic analysis revealed a ring chromosome 15. Despite a palliative banding operation of the pulmonary artery, the infant succumbed to complications of her congenital heart disease in the 4th month of life.
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  • 3
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Atemstörung ; Hypoventilation Maskenbeatmung (NIPPV) ; Myopathie Rigid-spine-Syndrom ; Key words Disordered breathing during sleep Hypoventilation ; Nasal intermittent positive pressure ventilation (NIPPV) ; Myopathy Rigid-spine-syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report the case of an 8 year old boy with a rare congenital myopathy (with cytoplasmic inclusions bodies) and clinical signs of rigid-spine-syndrome. During treatment of lung tuberculosis disordered breathing with hypoventilation during REM-sleep, hypoxemia and persistent hypercapnia during daytime were found. This complication in myopathies is caused by weakness of respiratory muscles and leads to negative features (like pulmonary hypertension, daytime-sleepiness, growth failure or further impairement of the muscle disease). Diagnostic steps in disorders of breathing during sleep in children with neuromuscular disease are shown. Conclusions: patients with congenital myopathies should be checked for impairment of respiratory muscle function and disordered breathing during sleep. Nasal intermittent positive pressure ventilation (NIPPV) is an effective and non-invasive treatment for the prevention of nocturnal hypoxemias in these patients and may improve life quality considerably.
    Notes: Zusammenfassung Es wird über einen 8jährigen Jungen mit einer seltenen kongenitalen Myopathie (myofibrilläre Myopathie mit zytoplasmatischen Einschlußkörperchen) und dem klinischen Bild eines Rigid-spine-Syndroms berichtet, bei dem im Rahmen der Behandlung einer Lungentuberkulose eine nächtliche Atemstörung mit REM-assoziierten Hypoventilationen, Hypoxämien und persistierender Hyperkapnie diagnostiziert wurde. Diese bei Myopathien vorkommende Komplikation ist Ausdruck einer Störung der Atempumpe; sie kann zahlreiche negative Auswirkungen nach sich ziehen (u.a. pulmonale Hypertonie, Tagesmüdigkeit, Wachstumsverzögerung, Gedeihstörung und weitere Verschlechterung der muskulären Insuffizienz). Exemplarisch werden die Schritte zur Diagnose einer schlafbezogenen Atemstörung bei muskelkranken Kindern aufgezeigt. Schlußfolgerung: Bei angeborenen Myopathien sollte sorgfältig nach Störungen der muskulären Atempumpe und schlafbezogenen Atemstörungen gefahndet werden. Eine intermittierende nasale Maskenbeatmung stellt eine effektive und nichtinvasive Behandlungsmöglichkeit nächtlicher Hypoventilationssyndrome dar und kann die Lebensqualität betroffener Patienten erheblich verbessern.
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  • 4
    ISSN: 1433-7339
    Keywords: Key words Emesis ; Radiotherapy ; Antiemetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The introduction of new antiemetics has resulted in renewed interest in the aetiology and control of radiation induced emesis. Studies both with fractionated treatment and with high-dose single exposures have clearly demonstrated the value of the 5HT3 receptor antagonist antiemetics. This paper reviews the selection of optimal antiemetics.
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  • 5
    ISSN: 1433-8580
    Keywords: Acute experimental pancreatitis ; Pain ; Enzymes ; Buprenorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Buprenorphine (15 µg/kg b.wt. per hour) distinctly reduced pain sensitivity in acute 3% sodium-taurocholate pancreatitis in male Wistar rats without interfering with the course of the disease. This was seen by assessment of enzyme elevation in serum and ascites and by histological evaluation of the pancreas. Buprenorphine is therefore recommended for animal experiments to study the effect of therapeutic principles in acute pancreatitis.
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  • 6
    ISSN: 1279-8509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 10 (1972), S. 103-106 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The facial pits of pit vipers are suited for thermal imaging. The difference of radiance between radiator and background necessary for evoking a reaction of the viper is 0.1 mW/cm2 for one pit; this corresponds to a difference of temperature of 0.3 to 0.4° C. The image formation of radiators on the membrane is similar to that of a pinhole camera. A point by point seperation on the membrane can't be achieved; however a point seperation by nervous processing is conceivable. The spatial cut-off frequency of image formation is 0.5 mm−1.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 147 (1957), S. 76-91 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Die thermodynamische Temperatur des Goldpunktes wird mit der neuen gasthermometrischen Methode konstanter Gefäßtemperatur (s. Teil I) gemessen. Eine wesentliche Verbesserung gegenüber allen bisherigen Messungen besteht außerdem darin, daß das doppelwandige Thermometergefäß aus Quarzglas vollständig in schmelzendes Gold eintaucht, wodurch beste räumliche Temperaturkonstanz erzielt wird. Systematische Fehler werden weitgehend ausgeschaltet oder erfaßt durch folgende Variationen der Versuchsbedingungen: Verwendung verschiedener Füllgase N2, Ar, CO2, Kr und Xe; Messung sowohl des Erstarrungsals auch des Schmelzpunktes bei verschiedenen Ausgangsdrucken, so daß eine Extrapolation auf den Druck Null (idealer Gaszustand) auch ohne Kenntnis der zweiten Virialkoeffizienten der Gase möglich ist; Kontrollversuche nach der Methode konstanten Volumens und konstanten Druckes mit derselben Apparatur. Für den Goldpunkt ergab sich:t Au=1064,76±0,1 °C oderT Au=1337,91±0,1 °K.
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  • 9
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Die thermische Ausdehnung von vier Quarzsorten (Herasil I, Ultrasil, Heralux und Rotosil) wurde nach Alterung bei 1080°C mit einer Absolutmethode im Temperaturbereich von 200 bis 1060°C gemessen. Nach achtstündiger Alterung bei 1080°C änderten sich die Ausdehnungskoeffizienten nicht mehr. Sie stimmten bei allen untersuchten Quarzglassorten innerhalb der Meßunsicherheit von etwa ±2% miteinander überein. Der mittlere lineare Ausdehnungskoeffizient zwischen 0 undt°C besitzt bei 300°C einen Maximalwert von 59·10−8 grd−1 und nimmt bis auf 47·10−8 grd−1 bei 1000°C ab.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 206 (1967), S. 223-228 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Mit der früher beschriebenen gasthermometrischen Methode „konstanter Gefäß-temperatur“ wurden drei weitere Fixpunkte gemessen: Erstarrungspunkt von Zinn 232,95 °C, Cadmium 321,10 °C und Aluminium 660,47 °C.
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