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  • Springer  (2)
  • 1
    Keywords: Oncology ; Oncology   ; Hematology ; Cytology ; Pharmacy ; Cancer Research ; Oncology ; Hematology ; Cell Biology ; Pharmacy ; Springer eBooks
    Description / Table of Contents: Preface -- Cancer screening and epidemiology -- Cancer stem cells -- Apoptosis -- Angiogenesis -- Genetic basis of metastasis -- Anti-cancer Drugs -- Immuno-oncology -- Health Econimics -- Small cell lung cancer -- Mesothelioma -- Thymus -- Breast -- Oesophageal -- Gastric -- Colon -- Rectal -- Anal Canal Cancer -- Small intestine -- Liver Cancer -- Pancreatic Cancer -- Ovarian -- Cervical -- Vagina -- Gestacional trophoblastic disease -- Prostate Cancer -- Renal Cell Carcinoma -- Urothelial Cancer -- Germ-Cell Tumors -- Penile Cancer -- Squamous Head and neck -- Thyroid cancer -- Parotid Gland Tumors -- Melanoma -- Soft Tissue Sarcomas -- Bone Sarcomas -- GIST -- NET -- Primary brain tumor -- Acute Lymphoblastic Leukemia -- Myelodisplastic Syndrome -- Metabolic disturbance/paraneoplasic syndromes -- Spinal medular compression -- Superior vena cava syndrome -- Febrile neutropenia -- Chemotherapy-Induced Nausea and Vomiting -- Asthenia -- Oncological pain -- Bone Metastases -- Brain metastasis -- Palliative care -- Index
    Abstract: Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments
    Pages: XV, 1162 p. 134 illus., 75 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9783030162450
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  • 2
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We have examined the dynamics of the localisation of the polo-like kinase 1 (Plk1) during maturation of the mouse oocyte. Levels of Plk1 protein increase following germinal vesicle breakdown, at which time the enzyme begins to accumulate at discrete positions on the condensing chromosomes and, subsequently, at the poles of the meiotic spindle, which moves towards the cortex of the egg. Interestingly, at metaphase in both meiotic divisions, Plk1 shows a punctate localisation along the broad spindle poles. Moreover, the punctate distribution of Plk1 on the meiotic chromosomes appears at early anaphase to correspond to the centromeric regions. The protein relocates to the spindle midzone during late anaphase and then associates with the midbody at telophase. We have confirmed the specific pattern of immuno-localisation seen in fixed preparations by observing the distribution of Plk1 tagged with green fluorescent protein in living oocytes. We discuss the localisation of the enzyme in light of the structure of the spindle poles, which are known to lack centrioles, and the highly asymmetric nature of the meiotic divisions.
    Type of Medium: Electronic Resource
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