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  • 1
    ISSN: 1435-1285
    Keywords: Key words sleep apnea – myocardial infarction – circadian rhythm ; Schlüsselwörter Schlafapnoe – Myokardinfarkt – zirkadiane Rhythmik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Auftreten des Myokardinfarktes zeigt ein zirkadianes Muster mit einem Maximum in den frühen Morgenstunden. Bei Patienten mit schlafbezogenen Atmungsstörungen (SBAS) ist zu mutmaßen, daß diese aufgrund der akuten apnoeassoziierten Veränderungen von Hämodynamik, Blutgasen und Rheologie vermehrt Myokardinfarkte im Schlaf aufweisen. In dieser Untersuchung wird die zirkadiane Verteilung von Myokardinfarkten bei Patienten mit und ohne SBAS analysiert. Bei 59 von 89 männlichen Patienten, die konsekutiv innerhalb eines Zeitraums von 20 Monaten mit akutem Myokardinfarkt auf die Intensivstation aufgenommen wurden, konnte zwischen dem 6. und 10. Tag nach Infarkt (Meßzeitpunkt I), bei 43 der 59 Patienten zwischen dem 22. und 28. Tag nach Infarkt (Meßzeitpunkt II) eine nächtliche Langzeitregistrierung von transkutaner Sauerstoffsättigung, Herzfrequenz, Atemgeräuschen und Körperlage mittels 4-Kanal-Diagnostiksystem (MESAM IV) durchgeführt werden. Eine Schlafapnoe mit einem RDI≥10/h war zum MZP I bei 44,1 % der Patienten nachweisbar, zum MZP II bei 39,5 %. Bei 22 % der Patienten mit sicher festzulegendem Infarktzeitpunkt trat der Infarkt im Schlaf auf. Die Patienten mit Myokardinfarkt im Schlaf hatten im Vergleich zu Patienten mit Myokardinfarkt im Wachzustand einen deutlich höheren RDI (MZP I: 22,7 vs. 9,4/h; p=0,08; MZP II: 20,3 vs. 7,3/h; p〈0,05). 53,6 % aller Infarkte waren im Zeitraum von 5.00 bis 11.00 Uhr nachweisbar. Untersuchungen an größeren Patientenkollektiven sind notwendig, um die vorliegenden Ergebnisse sowie die Relevanz des kardiovaskulären Risikofaktors Schlafapnoe zu bestätigen.
    Notes: Summary Myocardial infarction shows a circadian pattern with a maximum in the early morning hours. In patients with sleep-related breathing disorders (SRBD), it is assumed that apnea-associated changes of hemodynamics, blood gases, and rheology lead to a higher frequency of myocardial infarction during sleep. This investigation analyzes the circadian pattern of myocardial infarction in patients with and without SRBD. Within a time period of 20 months, 89 male patients with acute myocardial infarction were consecutively admitted to the intensive care unit. A nocturnal long-term registration of oxygen saturation, heart rate, breathing sounds, and body position by means of a 4-channel recording system (MESAM IV) was carried out in 59 of the 89 patients 6 to 10 days (evaluation I) and in 43 of 59 patients 22 to 28 days after infarction (evaluation II). Sleep apnea with a respiratory-disturbance-index (RDI≥10/h was found in 44.1/39.5% of the patients (evaluation I/II). In 22 % of the patients, time of infarction was during a sleeping period. Patients with myocardial infarction during sleep had a clearly higher RDI in comparison to patients with a myocardial infarction during wakefulness (evaluation I: 22.7 versus 9.4/h; p=0.08;evaluationII: 20.3 versus 7.3;p〈0.05). 53.6 % of all myocardial infarctions occurred during the time period 5:00–11:00 a.m. Investigations in a larger number of patients are necessary to confirm these results as well as the relevance of sleep apnea as a cardiovascular risk factor.
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  • 2
    ISSN: 1435-926X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
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  • 3
    Electronic Resource
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    Springer
    Metrika 19 (1972), S. 79-88 
    ISSN: 1435-926X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
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  • 4
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Resonance Ionization Mass Spectrometry (RIMS) has nowadays reached the status of a routine method for sensitive and selective ultratrace determination of long-lived radioactive isotopes in environmental, biomedical and technical samples. It provides high isobaric suppression, high to ultra-high isotopic selectivity and good overall efficiency. Experimental detection limits are as low as 106 atoms per sample and permit the fast and sensitive determination of ultratrace amounts of radiotoxic contaminations. Experimental arrangements for the detection of different radiotoxic isotopes, e.g. 236–244Pu, 89,90Sr and 99Tc in environmental samples are described, and the application of RIMS to the ultrarare long-lived radioisotope 41Ca for cosmochemical, radiodating and medical purposes are presented.
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  • 6
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Seltene kutane T-Zell-Lymphome ; Klassische kutane T-Zell-Lymphome ; Primär-progressive kutane T-Zell-Lymphome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Besides the classical forms of cutaneous T-cell lymphoma (C-CTCL), such as mycosis fungoides and Sézary's syndrome, unique variants may be encountered. The classification of these rare cutaneous T cell lymphomas is problematic and controversial. Newer classifications of lymphoma in general, such as the Revised European-American Lymphoma (REAL) Classification, emphasize well-established clinico-pathological entities. It seems appropriate to attempt to bring greater clarity to the classification of cutaneous T-cell lymphomas using the same principles. In this review, we list and characterize the rare variants of cutaneous T-cell lymphoma, such as (1) clinical, histological and immunological variants of mycosis fungoides; (2) progressive cutaneous T-cell lymphoma (P-CTCL) including transformed classical cutaneous T-cell lymphoma (TC-CTCL) and primary progressive cutaneous T-cell lymphoma (PP-CTCL); (3) angiocentric and angioimmunoblastic cutaneous T-cell lymphomas; (4) large cell anaplastic, CD30+ cutaneous T-cell lymphoma; (5) HTLV-Iassociated adult T-cell leukemia/lymphoma (ATLL); (6) cutaneous manifestations of primary extracutaneous T-cell neoplasias; (7) unclassifiable cutaneous T-cell lymphoma. Key words Rare cutaneous T-cell lymphomas – Classical cutaneous T-cell lymphomas – Primary-progressive cutaneous T-cell lymphomas
    Notes: Zusammenfassung Neben den klassischen kutanen T-Zell-Lymphomen (C-CTCL), wie der Mykosis fungoides und dem Sézary-Syndrom, kommen ungewöhnliche Varianten kutaner T-Zell-Lymphome vor, die als „seltene“ kutane T-Zell-Lymphome bezeichnet werden können. Die Einordnung dieser seltenen kutanen T-Zell-Lymphome ist problematisch und umstritten. Neuere Klassifikationen der Lymphome allgemein wie die Revised European-American Lymphoma (R.E.A.L.) Classification stellen wohldefinierte klinisch-morphologische Entitäten in den Vordergrund. In Anlehnung an den Grundgedanken dieser Klassifikation ist auch größere Klarheit bei den seltenen kuktanen T-Zell-Lymphomen zu erzielen. In dieser Übersicht wird der Versuch gemacht, die seltenen kutanen T-Zell-Lymphome aufzulisten und zu charakterisieren. Wir stellen dabei die folgende Einteilung vor, wobei insbesondere alle pleomorphen, immunoblastischen und großzellig-anaplastischen CD30 − kutanen T-Zell-Lymphome entsprechend ihrem Verlauf als progressive T-Zell-Lymphome zusammengefaßt werden: 1) Klinische Sonderformen und Varianten der Mykosis fungoides 2) progressive kutane T-Zell-Lymphome (P-CTCL) einschließlich der transformierten klassischen kutanen T-Zell-Lymphome (TC-CTCL) und der primär-progressiven kutanen T-Zell-Lymphome (PP-CTCL); 3) angiozentrisches und angioimmunoblastisches kutanes T-Zell-Lymphom; 4) großzellig-anaplastisches, CD30 + kutanes T-Zell-Lymphom; 5) HTLV-I-assoziierte adulte T-Zell-Leukämie/Lymphom (ATLL); 6) kutane Manifestationen primär extrakutaner T-Zell-Neoplasien; 7) andere, schwer klassifizierbare kutane T-Zell-Lymphome.
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  • 7
    ISSN: 1432-1041
    Keywords: Zidovudine ; acquired immunodeficiency syndrome (AIDS) ; pharmacokinetics ; bioavailability ; food intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The systemic availability of oral zidovudine has been studied in 13 patients with the acquired immunodeficiency syndrome (AIDS) dosed either fasting or with breakfast. The mean peak plasma concentration and AUC of zidovudine were significantly 2.8- and 1.4-times higher in fasting patients than in those treated during meal. In both conditions the mean half-life was about 1.5 h and the period of plasma zidovudine concentrations 〉1 μmol · l−1 was 2 h (NS). It is concluded that if zidovudine is taken on an empty stomach, high peak plasma concentrations and decreased variation in pharmacological parameters may be expected. Whether or not this will influence toxicity and efficacy remains to be shown.
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The chromosome region 5q22 harbouring the putative gene associated with adenomatous polyposis coli (APC) was microdissected and microcloned from GTG-banded human metaphase chromosomes. In order to determine the precise regional localization of the microdissected material, we used polymerase chain reaction amplified microclones as a bulk-probe in nonradioactive chromosomal in situ suppression hybridization of human metaphase spreads. Specific in situ hybridization signals were obtained on the long arm of chromosome 5 in accordance with the chromosomal region excised for the cloning procedure. The application of this detection system should provide a rapid and powerful tool for analyzing patients with translocations or microdeletions of a given chromosome region.
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  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosomal analysis in a child with ambiguous sex showed mosaicism of at least two cell lines with one or more marker chromosomes or none at all. They were shown to be derived from the Y chromosome by fluorescent in situ hybridisation (FISH) using different DNA probes that cover parts of the long and the short arm.
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  • 10
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The cosegregation of a reciprocal translocation t(17;19) (q11.2;13.2) with neurofibromatosis type 1 in three generations suggested that the breakpoint on chromosome 17 involved the NF1 gene. In order to map the breakpoint, we analysed DNAs of patients using parts of the NF1 gene as probes. Southern analysis revealed that the chromosome 17 breakpoint lies within intron 23 of the NF1 gene. One of the patients of the family developed a non-Hodgkin lymphoma. An additional translocation t(14;20) (q32;13.1) in his B lymphocytes points to a gene on chromosome 20 that is juxtaposed to the IGH locus on 14q32, and that may be of relevance for the development of this tumor type.
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