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  • German Medical Science GMS Publishing House; Düsseldorf  (6)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  126. Kongress der Deutschen Gesellschaft für Chirurgie; 20090428-20090501; München; DOC09dgch11286 /20090423/
    Publication Date: 2009-05-06
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20080430-20080504; Bonn; DOC08hnod305 /20080422/
    Publication Date: 2008-04-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 8; DOC31 /20081218/
    Publication Date: 2008-12-19
    Description: The provision of professional information in hospitals as well as the need of both physicians and purchasers to streamline the process by means of appropriate solutions challenge all players in the value chain. This article describes a case study from the evaluation of the status quo to the implementation of the resulting project steps.
    Description: Die umfassende Literaturversorgung in Kliniken und der gemeinsame Wunsch von Ärzten und Einkauf nach Optimierung durch den Einsatz geeigneter Lösungen stellt alle Betroffenen vor neue Herausforderungen. Der Artikel beschreibt eine Fallstudie von der Evaluierung der Ist-Situation bis zur Umsetzung der einzelnen Projektschritte.
    Keywords: subscription management ; journals ; online access ; provision ; optimization ; Gespag ; Swets ; SwetsWise ; migration to online ; Aboverwaltung ; Zeitschriften ; Online-Zugänge ; Bereitstellung ; Optimierung ; Gespag ; Swets ; Swetswise ; Umstellung auf Online ; ddc: 610
    Language: German
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20080430-20080504; Bonn; DOC08hnod297 /20080422/
    Publication Date: 2008-04-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 8; DOC04 /20130429/
    Publication Date: 2013-07-11
    Description: Background: Paromomycin is used for selective bowel decontamination (SBD) in patients undergoing bone marrow transplantation in many hospitals, but there are no published resistance data for this compound in the recent medical literature. The aim of this study was to investigate the in vitro activity of paromomycin against the common intestinal bacteria E. coli and P. aeruginosa .Methods: 94 E. coli isolates and 77 P. aeruginosa isolates derived from clinical specimens were tested by broth microdilution against paromomycin and amikacin, respectively, following the CLSI recommendations for testing amikacin.Results: 86 of 94 E. coli isolates (91%) and 71 of 77 P. aeruginosa isolates (92%) showed in vitro susceptibility to amikacin (MIC90 for both compounds: 16 µg/ml, range: 1-32 µg/ml for E. coli and 1-〉128 µg/ml for P. aeruginosa ). Paromomycin was active against 83/94 E. coli isolates (88%; MIC90: 32 µg/ml, range: 2-〉128 µg/ml), but showed poor in vitro activity against P. aeruginosa (3/77 isolates susceptible [4%]; MIC90: 〉128 µg/ml, range: 2-〉128 µg/ml).Conclusion: If SBD with inclusion of an aminoglycoside antibiotic is applied, paromomycin should not be used unless local resistance data provide evidence of a sufficient in vitro activity of this compound against P. aeruginosa .
    Description: Hintergrund: Paromomycin wird in zahlreichen Zentren bei Patienten, die vor einer Knochenmarktransplantation stehen, zur selektiven Darmdekontamination (SDD) eingesetzt. Dennoch findet sich in der Literatur keine Angaben der Resistenzlage Gram-negativer Bakterien gegenüber diesem Aminoglykosid-Antibiotikum. Ziel der vorliegenden Untersuchung war es, die In-vitro-Aktivität von Paromomycin gegen die typisch im Dickdarm habitierende Bakterien E. coli und P. aeruginosa zu bestimmen.Methoden: 94 E. coli -Isolate und 77 P. aeruginosa -Isolate, welche aus klinischem Probenmaterial isoliert wurden, wurden mittels Mikrodilutionsverfahren gegenüber Paromomycin und Amikacin getestet. Es wurden die CLSI Empfehlungen für Amikacin herangezogen. Ergebnisse: 86 von 94 E. coli -Isolaten (91%) und 71 von 77 P. aeruginosa -Isolaten (92%) zeigten In-vitro-Empfindlichkeit gegenüber Amikacin (MIC90 für beide Antibiotika: 16 µg/ml, range: 1-32 µg/ml für E. coli und 1-〉128 µg/ml für P. aeruginosa ). Paromomycin war aktiv gegenüber 83/94 E. coli -Isolaten (88%; MIC90: 32 µg/ml, range: 2-〉128 µg/ml), zeigte aber schwache In-vitro-Wirksamkeit gegenüber P. aeruginosa (3/77 Isolate empfindlich [4%]; MIC90: 〉128 µg/ml, range: 2-〉128 µg/ml).Schlussfolgerung: Sollte eine SDD routinemäßig mit Einschluss eines Aminoglykosid Antibiotikums durchgeführt werden, sollte Paromomycin nicht eingesetzt warden, außer bei Vorliegen lokaler Resistenzkenntnis für die In-vitro-Effektivität von Paromomycin gegenüber P. aeruginosa .
    Keywords: paromomycin ; P. aeruginosa ; E. coli ; minimal inhibitory concentration (MIC) ; selective bowel decontamination (SBD) ; Paromomycin ; P. aeruginosa ; E. coli ; Minimale Hemmkonzentration (MHK) ; Selektive Darm-Dekontamination (SDD) ; ddc: 610
    Language: English
    Type: article
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20181004-20181006; Wien; DOC18peg30 /20181008/
    Publication Date: 2018-10-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 7
    Publication Date: 2018-12-02
    Description: NADPH oxidase (NOX) enzymes are one of the major superoxide-generating systems in cells. NOX-generated superoxide has been suggested to promote insulin resistance in the liver. However, the role of NOX enzymes in mediating metabolic dysfunction in other insulin target tissues remains unclear. Here, we show that NOX3 expression is induced in differentiated 3T3-L1 adipocytes upon treatment with proinflammatory cytokines. Superoxide production increased concurrently with NOX3 protein expression in cytokine-treated adipocytes, which was inhibited by the NOX inhibitor diphenyleneiodonium (DPI). Treatment of adipocytes with cytokines increased lipolysis and decreased PPAR activity. Interestingly, treatment with DPI blunted lipolysis activation by cytokines but failed to restore PPAR activity. siRNA-mediated NOX3 downregulation also prevented cytokine-induced superoxide generation and lipolysis. In line with increasing lipolysis, cytokines increased the phosphorylation of hormone-sensitive lipase (HSL), which was reversed by treatment with DPI and silencing of NOX3 expression. We conclude that NOX3 is a cytokine-inducible superoxide-generating enzyme in adipocytes, which promotes lipolysis through increasing phosphorylation of HSL. This suggests a key role for NOX3-mediated superoxide production in the increased adipocyte lipolysis in inflammatory settings.
    Print ISSN: 0022-2275
    Electronic ISSN: 1539-7262
    Topics: Biology , Chemistry and Pharmacology , Medicine
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