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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mouse α4β2 nicotinic acetylcholine receptors (nAchRs) were stably expressed in HEK293T cells. The function of this stable cell line, termed mmα4β2, was assessed using an aequorin-based luminescence method that measures agonist-evoked changes in intracellular calcium. Agonist-elicited changes in intracellular calcium were due primarily to direct entry of calcium through the α4β2 channel, although release of calcium from intracellular stores contributed ˜ 28% of the agonist-evoked response. Agonist pharmacologies were very similar between the mmα4β2 cells and most cell lines that stably express human α4β2 nAchRs. Based on agonist profiles and sensitivity to the antagonist dihydro-β-erythroidine (DHβE), the predominant α4β2 nAchR expressed in the mmα4β2 cells exhibits a pharmacology that most resembles the DHβE-sensitive component of 86Rb+ efflux from mouse brain synaptosomes. However, when evaluated with the aequorin assay, the mmα4β2 nAchR was found to be atypically sensitive to blockade by the presumed α7-selective antagonist methyllycaconitine (MLA), exhibiting an IC50 value of 31 ± 0.1 nm. Similar IC50 values have been reported for the MLA inhibition of nicotine-stimulated dopamine release, a response that is mediated by β2-subunit-containing nAchRs and not α7-subunit-containing nAchRs. Consequently, at low nanomolar concentrations, MLA may not be as selective for α7-containing nAchRs as previously thought.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A new analysis technique has been developed to study the non-linear elastic mode interaction in thin-walled beam columns under ground excitation. The technique is capable of handling arbitrary cross-sectional shapes and end conditions. In the analysis of P - Δ effects in the building frames, the technique incorporates the instantaneous loss of stiffness due to local buckling of the individual plates in a rational and convenient manner. The latter is achieved via use of the finite-strip technique which is found to be extremely efficient in the local and post-local buckling analysis of prismatic plate structures. The overall behaviour is modelled by a one-dimensional finite element in which the effects of local buckling are appropriately incorporated. It is observed that moment frames lose stability at an axial load significantly lower than the static buckling load, even for moderate levels of earthquake.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 56 (2001), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ninety-one patients were randomly allocated to one of two groups. Group A was induced with a single vital capacity breath of 6% (end-tidal) sevoflurane in nitrous oxide–oxygen (2 : 1 l.min−1), whereas group B was induced with intravenous fentanyl 1 µg.kg−1+ propofol 2 mg.kg−1 followed by nitrous oxide–oxygen (2 : 1 l.min−1) and sevoflurane. Induction was considered to have been achieved when the bispectral index value decreased to below 70. Mean induction time in group A (95.2 s, 95% CI 88.5–101.9 s) was longer than group B (70.3 s, 95% CI 66.3–74.3 s; p 〈 0.0001). Mild coughing was more common in group A, but relative hypotension was more common in group B. There was no difference in the emergence times. Thirty minutes after emergence, there was no difference in the incidence of adverse effects, with the exception of essentially mild abdominal pain which was more frequent in group A.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty patients in early labour were randomly allocated to one of three groups. The control group received intrathecal fentanyl 25 µg, the ropivacaine group received intrathecal fentanyl 25 µg and ropivacaine 2.5 mg while the bupivacaine group received intrathecal fentanyl 25 µg and bupivacaine 2.5 mg. The incidence of pruritus was 100% in controls, compared with 85% in the ropivacaine group (not significant) and 75% in the bupivacaine group (p = 0.003). The severity of pruritus was significantly less in the ropivacaine (p = 0.006) and bupivacaine (p = 0.001) groups. Most patients developed pruritus by 30 min. Pruritus above the abdomen was not reduced in patients receiving local anaesthetics. There were no significant differences in the mean pain visual analogue score, systolic blood pressure, maternal heart rate and upper level of reduced pin-prick sensation in the first 30 min. Intrathecal ropivacaine and, more so, intrathecal bupivacaine reduce the incidence and severity of pruritus from intrathecal fentanyl for labour analgesia.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Antibiotic resistance is a significant problem both in hospitals and the community. Topical antibiotics are widely used for dermatological problems and this may be leading to the emergence of resistant bacteria. Objective To assess the level of fusidic acid-resistant Staphylococcus aureus inpatients with dermatological problems. Methods All microbiology samples over a 4-month period were tested for antibiotic sensitivities. Patients with cultures positive for S. aureus were studied. Results The study shows 50% of S. aureus isolates from dermatology patients were resistant to fusidic acid. This figure rose to 78% inpatients with atopic eczema. Of patients with fusidic acid-resistant S. aureus isolates, 96% had used a fusidic acid-containing preparation within the previous 6 months. The level of fusidic acid resistance in S. aureus samples cultured from nondermatology patients was only 9·6%, a level significantly below that for dermatology patients (P 〈 0·001). Conclusions High levels of fusidic acid-resistant S. aureus are found in dermatology patients. Inappropriate use of topical antibiotics in dermatology patients leading to fusidic acid resistance may threaten the efficacy of systemic fusidic acid for the treatment of serious S. aureus infections. Education of health professionals and restriction of the use of fusidic acid is needed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 37 (1991), S. 394-402 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The production of particulate magnetic disks or tapes requires consistent and uniform magnetic characteristics over the entire disk or tape to have as few defects as possible. To achieve this goal, the magnetic particle suspension used to coat the disk must be well dispersed. This article describes the use of a rheomagnetic instrument that provides an indirect measurement of the dispersion quality prior to coating application. The instrument was designed, tested, and put on a manufacturing scale line to characterize the relationships between the measured dispersion quality and functional characteristics of the magnetic coating. The results of tests done during scaleup for production yielded a qualitative correlation between the in-situ measurements made on the magnetic particle suspension at the coater with the surface roughness due to flocs, the on-disk orientation ratio, and the signal to noise ratio. The current results are the first demonstration of the dispersion quality measurement in a practical manufacturing environment.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A theoretical analysis for the laminar flow past arbitrary external surfaces of non-Newtonian fluids of the power-law model is presented. The main problem which is considered is how to predict the drag and the rate of heat transfer from an isothermal surface to the fluid. Inspectional analysis of the modified boundary-layer equations yields a general relationship both for the drag coefficient and for the Nusselt number as functions of the generalized Reynolds and Prandtl numbers. The flow past a horizontal flat plate is studied in detail numerically.
    Additional Material: 4 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 8 (1962), S. 542-549 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 95 (1946), S. 457-460 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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