Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Pathogenic Nocardia spp. converted rokitamycin, midecamycin and erythromycin into inactive metabolites, the structures of which were determined from NMR and mass spectral data. Depending on the species of Nocardia, these macrolides underwent phosphorylation at 2′-OH, hydrolysis of the 4″-O-acyl group, glycosylation at 2′-OH and/or reduction of the 18-formyl group. Full 1H and 13C assignments are presented and some solvent effects are described.
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