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  • α-Synuclein  (1)
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  • 1
    ISSN: 1432-0533
    Keywords: Key words Dementia with Lewy bodies ; Lewy bodies ; Parkinson’s disease ; α-Synuclein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lewy bodies (LB) and pale bodies (PB), their putative precursors, can be found in a spectrum of diseases characterized by parkinsonism and/or dementia. Furthermore, LB are occasionally observed in some other neurodegenerative diseases and in normal aging. Classical LB are typically found in the brain stem, especially in the substantia nigra, where these inclusions are associated with neuronal loss and clinical signs of idiopathic Parkinson’s disease (PD). The so-called cortical LB occur in the cerebral cortex, amygdala and claustrum with little or no neuronal loss and are clinically associated with dementia in dementia with LB (DLB). We describe a patient without apparent clinical signs of parkinsonism and/or dementia, whose brain contained numerous classical-like LB, pale inclusions with features of PB and transitions between these two. These inclusions had similar immunohistological (ubiquitin positive; neurofilament positive; tau negative) and ultrastructural features as the LB in PD and DLB except for the lack of immunoreactivity for α-synuclein. The pons and cerebral cortex showed the highest number of LB, up to 165/1.76 mm2. These numbers were contrasted by the lack of obvious neuronal loss or gliosis. The absence of α-synuclein reactivity in the LB in this symptomless patient corroborates the hypothesis that α-synuclein accumulation in LB is an important step in neurodegeneration in PD and DLB, but tones down the role of α-synuclein in LB formation in general. This patient seems to represent a new variant in the spectrum of diseases associated with LB.
    Type of Medium: Electronic Resource
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