(-)-Hypnophilin, enantiomerically pure
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Chemistry and Stereochemistry of Iridoids, XVI. - EPC-Synthesis of (-)-HypnophilinThe synthesis of enantiomerically pure (-)-hypnophilin (27) from (6R,7R)-(-)-7-hydroxy-3-oxabicyclo[4.3.0]non-1-en-9-one (1) is described. 1 was obtained in 93% yield from catalpol, which is readily available from the aqueous sodium carbonate extract of Picrorhiza kurrooa (Scrophulariaceae). The specific rotation, MS, 1H- and 13C-NMR data of synthetic (-)-hypnophilin were identical with those of the natural product.
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