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  • 1
    ISSN: 1432-1920
    Keywords: Pituitary adenomas ; Angiotomography ; Empty sella ; Carotid angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The supra sellar extension of even small sized pituitary adenomas can be delineated with accuracy by angiotomography. This technique avoids the discomfort of pneumoencephalography in many patients. Angiotomography is also useful for the differential diagnosis of empty sellae.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2011-07-19
    Description: During early lung development, airway tubes change shape. Tube length increases more than circumference as a large proportion of lung epithelial cells divide parallel to the airway longitudinal axis. We show that this bias is lost in mutants with increased extracellular signal-regulated kinase 1 (ERK1) and ERK2 activity, revealing a link between the ERK1/2 signaling pathway and the control of mitotic spindle orientation. Using a mathematical model, we demonstrate that change in airway shape can occur as a function of spindle angle distribution determined by ERK1/2 signaling, independent of effects on cell proliferation or cell size and shape. We identify sprouty genes, which encode negative regulators of fibroblast growth factor 10 (FGF10)-mediated RAS-regulated ERK1/2 signaling, as essential for controlling airway shape change during development through an effect on mitotic spindle orientation.〈br /〉〈br /〉〈a href="" target="_blank"〉〈img src="" border="0"〉〈/a〉   〈a href="" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Nan -- Marshall, Wallace F -- McMahon, Martin -- Metzger, Ross J -- Martin, Gail R -- 5T32HL007185/HL/NHLBI NIH HHS/ -- R01 CA131201/CA/NCI NIH HHS/ -- R01 CA131261/CA/NCI NIH HHS/ -- R01 CA78711/CA/NCI NIH HHS/ -- R01 DE17744/DE/NIDCR NIH HHS/ -- R01 GM077004/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):342-5. doi: 10.1126/science.1204831.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Cell Polarity ; Cell Proliferation ; Cell Shape ; Cell Size ; Epithelial Cells/cytology ; Fibroblast Growth Factor 10/genetics/metabolism ; Intracellular Signaling Peptides and Proteins ; Lung/cytology/*embryology/metabolism ; *MAP Kinase Signaling System ; Membrane Proteins/genetics/metabolism ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 1/*metabolism ; Mitogen-Activated Protein Kinase 3/*metabolism ; Mitosis ; Models, Biological ; *Morphogenesis ; Mutation ; Organogenesis ; Phosphoproteins/genetics/metabolism ; Phosphorylation ; Proto-Oncogene Proteins p21(ras)/genetics/*metabolism ; Respiratory Mucosa/cytology/*embryology ; Spindle Apparatus/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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