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  • 3-methoxybenzamide  (1)
  • biventricular pacing
  • 1
    ISSN: 1573-5044
    Keywords: 5-azacytidine ; betacyanins ; betaxanthins ; differentiation ; 3-methoxybenzamide ; red beet cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Red beet cell lines exhibiting a range of cell colours were generated from secondary callus via specific induction methods. Phenotype colour ranged from white/green through yellow, orange and red to deep violet, representing all types of pigments found in red beet plant. Specific phenotypes could only be obtained through specific induction sequences and once established were stabilised by cultivation on a maintenance medium. The ratio of auxin (2,4-D) to cytokinin (6-BAP) was an important factor in the control of these processes. All coloured phenotypes were linked, but could be classified into two main groups, one yellow-red and the other orange-violet, according to their different cellular morphologies. A certain amount of instability still existed within each group. Modification of the growth regulator composition could be used to interchange specific combinations of coloured phenotypes, depending upon the initial state of cellular differentiation. Use of the DNA-methylation inhibitor 5-azacytidine demonstrated that methylation plays a key role in the repression of genes encoding enzymes involved in betacyanin biosynthesis. Furthermore, the poly(ADP-ribose) polymerase inhibitor 3-methoxybenzamide blocked the induction of the same gene set in a concentration dependent manner without affecting cell growth.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-8595
    Keywords: biatrial pacing ; biventricular pacing ; pacemaker indication ; coronary sinus electrodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The artificial activation of the heart modifies the mechanics of contraction and relaxation. While only little basic research has been addressed to this question, clinical observations showed that for hypertrophic as well as dilated cardiomyopathies appropriate pacing techniques can be useful. Pacing can influence the activation sequence. The spread out from a single site is slow, and so hypercontractility deminshed. With the use of multiple electrodes, two atrial and/or two ventricular, conduction delays in the atria or ventricles can be eliminated. Synchronisation of the cardiac activation has an anti-arrhythmic and positiv inotropic effect. This may lead to new indications for pacemakers or better to be named cardiac synchronisers.
    Type of Medium: Electronic Resource
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