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  • 3D digitizing  (1)
  • AAV2 VECTORS  (1)
  • biventricular pacing
  • 1
    Keywords: PEPTIDE ; CELLS ; EXPRESSION ; CELL ; Germany ; human ; IN-VIVO ; THERAPY ; VIVO ; SAMPLE ; SAMPLES ; INFECTION ; SERA ; DOMAIN ; BINDING ; LIMITATION ; antibodies ; antibody ; NEUTRALIZING ANTIBODIES ; virus ; IDENTIFICATION ; VECTORS ; VECTOR ; EFFICIENT ; TRAFFICKING ; REGION ; REGIONS ; SURFACE ; EPITOPE ; EPITOPES ; PREVALENCE ; adeno-associated virus ; TYPE-2 ; ADENOVIRUS ; AAV ; AAV2 VECTORS ; AFFINITY ; CANINE PARVOVIRUS ; DOMAINS ; EMPTY CAPSIDS ; NEUTRALIZATION ; immunogenic epitopes ; AAV antibodies ; human serum sampl
    Abstract: The high prevalence of human serum antibodies against adeno-associated virus type 2 (AAV) vectors represents a potential limitation for in vivo applications. Consequently, the development of AAV vectors able to escape antibody binding and neutralization is of importance. To identify capsid domains which contain major immunogenic epitopes, six AAV capsid mutants carrying peptide insertions in surface exposed loop regions (I-261, I-381, I-447, I-534, I-573, I-587) were analyzed. Two of these mutants, I-534 and I-573, showed an up to 70% reduced affinity for AAV antibodies as compared to wild-type AAV in the majority of serum samples. In addition, AAV mutant I-587 but not wild-type AAV efficiently transduced cells despite the presence of neutralizing antisera. Taken together, the results show that major neutralizing effects of human AAV antisera might be overcome by the use of AAV capsid mutants
    Type of Publication: Journal article published
    PubMed ID: 14625569
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  • 2
    ISSN: 1432-2315
    Keywords: B-spline surfaces ; Surface fitting ; Facial animation ; FACS ; 3D digitizing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper describes a technique for the automatic adaptation of a canonical facial model to data obtained by a 3D laser scanner. The facial model is a B-spline surface with 13×16 control points. We introduce a technique by which this canonical model is fit to the scanned data and that takes into consideration the requirements for the animation of facial expressions. The animation of facial expressions is based on the facial action coding system (FACS). Using B-splines in combination with FACS, we automatically create the impression of a moving skin. To increase the realism of the animation we map textural information onto the B-spline surface.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-8595
    Keywords: biatrial pacing ; biventricular pacing ; pacemaker indication ; coronary sinus electrodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The artificial activation of the heart modifies the mechanics of contraction and relaxation. While only little basic research has been addressed to this question, clinical observations showed that for hypertrophic as well as dilated cardiomyopathies appropriate pacing techniques can be useful. Pacing can influence the activation sequence. The spread out from a single site is slow, and so hypercontractility deminshed. With the use of multiple electrodes, two atrial and/or two ventricular, conduction delays in the atria or ventricles can be eliminated. Synchronisation of the cardiac activation has an anti-arrhythmic and positiv inotropic effect. This may lead to new indications for pacemakers or better to be named cardiac synchronisers.
    Type of Medium: Electronic Resource
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