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    Keywords: RECEPTOR ; CELLS ; CELL ; Germany ; human ; DISTINCT ; MOLECULES ; TIME ; ACTIVATION ; COMPLEX ; MECHANISM ; DENDRITIC CELLS ; mechanisms ; T cell ; T cells ; T-CELL ; T-CELLS ; SIGNAL ; MOLECULE ; cytokines ; RECOGNITION ; STIMULATION ; ACID ; ACQUISITION ; EFFICIENT ; LYMPHOCYTES ; EXCHANGE ; NATURAL-KILLER-CELLS ; ANTIGEN-PRESENTING CELLS ; CD8(+) ; specificity ; LIVE CELLS ; RECEPTORS ; CYTOKINE ; T-CELL-ACTIVATION ; interaction ; dendritic cell ; PHASE ; EVENTS ; USA ; SIGNALS ; immunology ; exosomes ; detachment ; INTERCELLULAR TRANSFER ; PEPTIDE-MHC COMPLEXES
    Abstract: Activation of CD4(+) T cells by APCs occurs by multiple Ag recognition events including the exchange of costimulatory signals and cytokines. Additionally, the T cells acquire APC-derived surface molecules. Herein, we describe for the first time the transfer of human and murine T cell surface receptors to APCs after Ag-specific interaction. This transfer occurs in two qualitatively different phases. The first group of molecules (e.g., CD2) derived from the T cell surface was transferred rapidly after 2 h of interaction, was strongly bound on the DC surface (acid wash-resistant), was strictly dependent on dendritic cell-T cell contact, and transferred independently of T cell activation. The second group, including the CD3/TCR complex, CD27, and OX40, was of intracellular origin, transferred later after 10-16 h in a cell-cell contact-independent fashion, was noncovalently bound, and was strictly dependent on Ag-specific T cell activation. Functionally, murine dendritic cells that received TCR molecules from OVA-specific CD4(+) T cells after Ag-specific interaction were less efficient in priming naive CD4(+) T cells of the same specificity without losing their ability for CD8(+) T cell stimulation, indicating that the transferred TCR molecules mask the Ag-bearing MHC II molecules, thereby reducing their accessibility to following Ag-specific CD4(+) T cells. While the first. group of transferred T cell surface molecules might facilitate the detachment of the CD4+ T cell from the dendritic cell during the early scanning phases, the second group could play an important immunomodulatory role in intraclonal competition of T cells for APC access, making the physical presence of CD4(+) T cells unnecessary
    Type of Publication: Journal article published
    PubMed ID: 18768851
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