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  • ACTIN, adhering junctions, ADHESION, ALPHA, beta-catenin, BIOLOGY, BLOOD, BODY, BONE-MARROW, cadheri  (1)
  • BLOOD  (1)
  • COMPLEX  (1)
Keywords
  • 1
    Keywords: ANGIOGENESIS ; CELLS ; ENDOTHELIAL-CELLS ; IN-VITRO ; BLOOD ; Germany ; human ; IN-VIVO ; VITRO ; SYSTEM ; PROTEIN ; PROTEINS ; desmoplakin ; TISSUE ; COMPLEX ; COMPLEXES ; TISSUES ; beta-catenin ; TIGHT JUNCTIONS ; rodent ; JUNCTIONS ; LYMPHATIC ENDOTHELIUM ; RE ; DESMOSOMAL PLAQUE ; INTERCELLULAR-JUNCTIONS ; DESMOSOMAL PLAQUE PROTEINS ; SIZE ; ADHERENS JUNCTIONS ; BOVINE ; function ; lymph node ; LYMPH-NODE ; N-CADHERIN ; adhering junction ; VE-CADHERIN ; BLOOD-BRAIN-BARRIER ; Complexus adhaerens ; DESMOPLAKIN-CONTAINING JUNCTIONS ; HUMAN GLIOBLASTOMA-MULTIFORME ; retothelium ; TO-CELL JUNCTIONS
    Abstract: The significance of a special kind of VE-cadherin-based, desmoplakin- and plakoglobin-containing adhering junction, originally identified in certain endothelial cells of the mammalian lymphatic system ( notably the retothelial cells of the lymph node sinus and a subtype of lining endothelial cells of peripheral lymphatic vessels), has been widely confirmed and its importance in the formation of blood and lymph vessels has been demonstrated in vivo and in vitro. We have recently extended the molecular and structural characterization of the complexus adhaerens and can now report that it represents a rare and special combination of components known from three other major types of cell junction. It comprises zonula adhaerens proteins (VE-cadherin, alpha- and beta-catenin, protein p120(ctn), and afadin), desmosomal plaque components ( desmoplakin and plakoglobin), and tight-junction proteins (claudin-5 and ZO-1) and forms junctions that vary markedly in size and shape. The special character and the possible biological roles of the complexus adhaerens and its unique ensemble of molecules in angiogenesis, immunology, and oncology are discussed. The surprising finding of claudin-5 and protein ZO-1 in substructures of retothelial cell-cell bridges, i.e., structures that do not separate different tissues or cell layer compartments,suggests that such tight-junction molecules are involved in functions other than the "fence" and "barrier" roles of zonulae occludentes
    Type of Publication: Journal article published
    PubMed ID: 16372193
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  • 2
    Keywords: ACTIN, adhering junctions, ADHESION, ALPHA, beta-catenin, BIOLOGY, BLOOD, BODY, BONE-MARROW, cadheri
    Abstract: Substrate-adherent cultured cells derived from human bone marrow or umbilical cord blood ("mesenchymal stem cells") are of special interest for regenerative medicine. We report that such cells, which can display considerable heterogeneity with respect to their cytoskeletal protein complement, are often interconnected by special tentacle-like cell processes contacting one or several other cells. These processus adhaerentes, studded with many (usually small) puncta adhaerentia and varying greatly in length (up to more than 400 mu m long), either contact each other in the intercellular space ("ET touches") or insert in a tight-fitting manner into deep plasma membrane invaginations (recessus adhaerentes), thus forming a novel kind of long (up to 50 mu m) continuous cuff-like junction (manubria adhaerentia). The cell processes contain an actin microfilament core that is stabilized with ezrin, alpha-actinin, and myosin and accompanied by microtubules, and their adhering junctions are characterized by a molecular complement comprising the transmembrane glycoproteins N-cadherin and cadherin-11, in combination with the cytoplasmic plaque proteins alpha- and beta-catenin, together with p120(ctn), plakoglobin, and afadin. The processes are also highly dynamic and rapidly foreshorten as cell colonies approach a denser state of cell packing. These structures are obviously able to establish cell-cell connections, even over long distances, and can form deep-rooted and tight cell-cell adhesions. The possible relationship to similar cell processes in the embryonic primary mesenchyme and their potential in cell sorting and tissue formation processes in the body are discussed
    Type of Publication: Journal article published
    PubMed ID: 17372769
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