Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • ANGIOGENESIS  (1)
  • Active oxygen  (1)
  • 1
    Keywords: ANGIOGENESIS ; CANCER ; CELLS ; GROWTH ; tumor ; BLOOD ; CELL ; IN-VIVO ; MODEL ; MODELS ; POPULATION ; DIFFERENTIATION ; TUMORS ; MICE ; DENDRITIC CELLS ; BIOLOGY ; MATURATION ; MOUSE ; HUMAN-TUMORS ; SURVEILLANCE ; immune response ; IMMUNE-RESPONSE ; IMMUNITY ; IMMUNOTHERAPY ; MOUSE MODEL ; CHILDREN ; PRECURSORS ; microenvironment ; PROGRAM ; fibroblast ; TUMOR-GROWTH ; ABLATION ; SUPPLEMENTATION ; DEPLETION ; vasculogenesis ; PROGENITORS ; immune cells ; CELL BIOLOGY ; BOSTON ; IMMUNE
    Abstract: Dendritic cells (DCs)-immunomodulatory cells that initiate adaptive immune responses-have recently been shown to exert proangiogenic effects when infiltrating the tumor microenvironment. As tumors that escape immune surveillance inhibit DC maturation, we explored whether maturation status determines their ability to promote angiogenesis and whether angiogenesis depends on the presence of DCs. Using mouse xenograft models of human tumors, we show that fast-growing "angiogenic" tumors are infiltrated by a more immature DC population than respective dormant avascular tumors. Accordingly, supplementation of immature DCs, but not mature DCs, enhanced tumor growth. When DCs were mixed with Matrigel and injected subcutaneously into mice, only immature DCs promoted the ingrowth of patent blood vessels. Notably, depletion of DCs in a transgenic mouse model that allows for their conditional ablation completely abrogated basic fibroblast growth factor-induced angiogenesis in Matrigel plugs, and significantly inhibited tumor growth in these mice. Because immature DCs actively promote angiogenesis and tumor growth, whereas DC maturation or ablation suppresses this response, we conclude that angiogenesis is dependent on the presence of immature DCs. Thus, cancer immunotherapies that promote DC maturation may act by both augmenting the host immune response to the tumor and by suppressing tumor angiogenesis.-Fainaru, O., Almog, N., Yung, C. W., Nakai, K., Montoya-Zavala, M., Abollahi, A., D'Amato, R., Ingber, D. E. Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J. 24, 1411-1418 (2010). www.fasebj.org
    Type of Publication: Journal article published
    PubMed ID: 20008545
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1420-9071
    Keywords: Active oxygen ; rabbit polymorphonuclear leukocyte ; thiol protease inhibitor ; chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The specific thiol protease inhibitor, NCO-700, which is related to L-trans-epoxysuccinylpeptides, inhibited oxidant production by chemoattractant-stimulated rabbit polymorphonuclear leukocytes. NCO-700 could also scavenge active oxygen generated from sodium hypochlorite-hydrogen peroxide and hypoxanthine-xanthine oxidase systems.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...