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  • Meningioma  (2)
  • ANGIOGENESIS  (1)
  • Active oxygen  (1)
  • 1
    Keywords: ANGIOGENESIS ; CANCER ; CELLS ; GROWTH ; tumor ; BLOOD ; CELL ; IN-VIVO ; MODEL ; MODELS ; POPULATION ; DIFFERENTIATION ; TUMORS ; MICE ; DENDRITIC CELLS ; BIOLOGY ; MATURATION ; MOUSE ; HUMAN-TUMORS ; SURVEILLANCE ; immune response ; IMMUNE-RESPONSE ; IMMUNITY ; IMMUNOTHERAPY ; MOUSE MODEL ; CHILDREN ; PRECURSORS ; microenvironment ; PROGRAM ; fibroblast ; TUMOR-GROWTH ; ABLATION ; SUPPLEMENTATION ; DEPLETION ; vasculogenesis ; PROGENITORS ; immune cells ; CELL BIOLOGY ; BOSTON ; IMMUNE
    Abstract: Dendritic cells (DCs)-immunomodulatory cells that initiate adaptive immune responses-have recently been shown to exert proangiogenic effects when infiltrating the tumor microenvironment. As tumors that escape immune surveillance inhibit DC maturation, we explored whether maturation status determines their ability to promote angiogenesis and whether angiogenesis depends on the presence of DCs. Using mouse xenograft models of human tumors, we show that fast-growing "angiogenic" tumors are infiltrated by a more immature DC population than respective dormant avascular tumors. Accordingly, supplementation of immature DCs, but not mature DCs, enhanced tumor growth. When DCs were mixed with Matrigel and injected subcutaneously into mice, only immature DCs promoted the ingrowth of patent blood vessels. Notably, depletion of DCs in a transgenic mouse model that allows for their conditional ablation completely abrogated basic fibroblast growth factor-induced angiogenesis in Matrigel plugs, and significantly inhibited tumor growth in these mice. Because immature DCs actively promote angiogenesis and tumor growth, whereas DC maturation or ablation suppresses this response, we conclude that angiogenesis is dependent on the presence of immature DCs. Thus, cancer immunotherapies that promote DC maturation may act by both augmenting the host immune response to the tumor and by suppressing tumor angiogenesis.-Fainaru, O., Almog, N., Yung, C. W., Nakai, K., Montoya-Zavala, M., Abollahi, A., D'Amato, R., Ingber, D. E. Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J. 24, 1411-1418 (2010). www.fasebj.org
    Type of Publication: Journal article published
    PubMed ID: 20008545
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  • 2
    ISSN: 1432-1920
    Keywords: Embolization ; Gelfoam powder ; Iodinated contrast medium ; Meningioma ; Polyvinyl alcohol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Study of the MRI changes that occur after superselective embolization of hypervascular meningiomas with Gelfoam powder (5 cases) and polyvinyl alcohol (PVA) particles 150–250 μm in size (4 cases) has indicated that, after embolization, meningiomas showed loss of the signal void, decrease in gadolinium-DTPA contrast enhancement, and prolonged T1 and T2. Shortening of T1 and T2 was seen in two patients with Gelfoam-embolized meningiomas in whom CT showed pooling of iodinated contrast medium in the tissue. In vitro experimental data demonstrated that the shortening of T1 and T2 was due to the iodinated contrast medium.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1920
    Keywords: Key words Embolisation ; Meningioma ; intraventricular ; Radiosurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 58-year-old woman with a presumed incidentally discovered meningioma in the left lateral ventricle was treated by superselective embolisation and gamma knife therapy. The diameter of the tumour was 40 mm, and its main feeding artery was the left lateral posterior choroidal artery. This vessel was embolised with microcoils. At 8 months following embolisation, the diameter of the tumour had decreased and was stable. The gamma knife was chosen as an adjuvant therapy for the further control 13 months after embolisation. Embolisation and gamma knife therapy may be an alternative treatment for meningiomas where surgical resection appears difficult.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-9071
    Keywords: Active oxygen ; rabbit polymorphonuclear leukocyte ; thiol protease inhibitor ; chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The specific thiol protease inhibitor, NCO-700, which is related to L-trans-epoxysuccinylpeptides, inhibited oxidant production by chemoattractant-stimulated rabbit polymorphonuclear leukocytes. NCO-700 could also scavenge active oxygen generated from sodium hypochlorite-hydrogen peroxide and hypoxanthine-xanthine oxidase systems.
    Type of Medium: Electronic Resource
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