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    Publication Date: 2013-08-03
    Description: Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Francalacci, Paolo -- Morelli, Laura -- Angius, Andrea -- Berutti, Riccardo -- Reinier, Frederic -- Atzeni, Rossano -- Pilu, Rosella -- Busonero, Fabio -- Maschio, Andrea -- Zara, Ilenia -- Sanna, Daria -- Useli, Antonella -- Urru, Maria Francesca -- Marcelli, Marco -- Cusano, Roberto -- Oppo, Manuela -- Zoledziewska, Magdalena -- Pitzalis, Maristella -- Deidda, Francesca -- Porcu, Eleonora -- Poddie, Fausto -- Kang, Hyun Min -- Lyons, Robert -- Tarrier, Brendan -- Gresham, Jennifer Bragg -- Li, Bingshan -- Tofanelli, Sergio -- Alonso, Santos -- Dei, Mariano -- Lai, Sandra -- Mulas, Antonella -- Whalen, Michael B -- Uzzau, Sergio -- Jones, Chris -- Schlessinger, David -- Abecasis, Goncalo R -- Sanna, Serena -- Sidore, Carlo -- Cucca, Francesco -- HG005552/HG/NHGRI NIH HHS/ -- HG005581/HG/NHGRI NIH HHS/ -- HG006513/HG/NHGRI NIH HHS/ -- HG007022/HG/NHGRI NIH HHS/ -- N01-AG-1-2109/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):565-9. doi: 10.1126/science.1237947.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dipartimento di Scienze della Natura e del Territorio, Universita di Sassari, Sassari, Italy. pfrancalacci@uniss.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908240" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Chromosomes, Human, Y/*classification/*genetics ; European Continental Ancestry Group/*genetics ; *Evolution, Molecular ; Haplotypes ; Humans ; Italy ; Male ; Phylogeny ; Polymorphism, Single Nucleotide
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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