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    Publication Date: 2014-02-01
    Description: Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, Suomeng -- Stam, Remco -- Cano, Liliana M -- Song, Jing -- Sklenar, Jan -- Yoshida, Kentaro -- Bozkurt, Tolga O -- Oliva, Ricardo -- Liu, Zhenyu -- Tian, Miaoying -- Win, Joe -- Banfield, Mark J -- Jones, Alexandra M E -- van der Hoorn, Renier A L -- Kamoun, Sophien -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):552-5. doi: 10.1126/science.1246300.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24482481" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence/genetics ; Amino Acid Substitution/genetics ; Evolution, Molecular ; Mirabilis/*enzymology/*microbiology ; Phylogeny ; Phytophthora infestans/genetics/*pathogenicity ; Plant Diseases/*microbiology ; Plant Proteins/classification/genetics/*metabolism ; Polymorphism, Genetic ; Proteinase Inhibitory Proteins, Secretory/classification/genetics/*metabolism ; Solanum tuberosum/*enzymology/*microbiology ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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