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  • 1
    Publication Date: 2011-01-22
    Description: Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-lambda expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-lambda-mediated immune response to control bacterial colonization of the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lebreton, Alice -- Lakisic, Goran -- Job, Viviana -- Fritsch, Lauriane -- Tham, To Nam -- Camejo, Ana -- Mattei, Pierre-Jean -- Regnault, Beatrice -- Nahori, Marie-Anne -- Cabanes, Didier -- Gautreau, Alexis -- Ait-Si-Ali, Slimane -- Dessen, Andrea -- Cossart, Pascale -- Bierne, Helene -- 233348/European Research Council/International -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1319-21. doi: 10.1126/science.1200120. Epub 2011 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Pasteur, Unite des Interactions Bacteries Cellules, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Chromatin/*metabolism ; Chromosomal Proteins, Non-Histone/*metabolism ; Down-Regulation ; Gene Expression Profiling ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Interferons/genetics/immunology/*metabolism ; Interleukins/genetics/immunology/*metabolism ; Listeria monocytogenes/genetics/metabolism/*pathogenicity ; Listeriosis/*immunology/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Sequence Data ; Signal Transduction ; Virulence Factors/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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