[3 + 2] Cycloaddition reactions
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Synthesis of 2-Heteroaryl-Substituted 3,3,3-Trifluoroalanine and 3,3,3-Trifluorolactic Acid DerivativesTrifluoromethyl-substituted alkynyl α-amino acid as well as alkynyl α-hydroxy acid esters and 1,3-dipoles (nitrile oxides, diazoalkanes, phenyl azide) react regioselectively to give α-trifluoromethyl-substituted heterocyclic α-amino and α-hydroxy acid derivatives, respectively.
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