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  • 1
    Electronic Resource
    Electronic Resource
    Amino acids 7 (1994), S. 245-254 
    ISSN: 1438-2199
    Keywords: Amino acids ; AP-1 ; c-fos ; c-jun ; zif/268 ; NGF-IA ; egr-1 ; krox-24 ; NMDA ; Neurons ; Glia ; Neural plasticity ; Excitatory amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary L-glutamate (L-glu) is major excitatory neurotransmitter in mammalian central nervous system. Besides short term effects on neuronal activity, L-glu affects also long term neuronal and glial responses. Neuromodulatory function of L-glu may in part be dependent on its ability to activate transcription factors — proteins regulating gene expression through interaction with specific regulatory sequences located in promoter and enhancer gene regions. This paper reviews recent data suggesting that L-glu can selectively stimulate genes encoding transcription factors like zif/268 and fos and jun gene families, as well as the factors themselves both in neurons and astroglia cultured in vitro and brain cells in vivo.
    Type of Medium: Electronic Resource
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