3′,5′-O-(Di-tert-butylsilanediyl) nucleosides DESERT 1H NMR
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The solution conformations of nine 3′,5′-O-(di-tert-butylsilanediyl) nucleosides, new sila analogues of cyclic nucleotides, were studied by proton NMR spectroscopy. The furanose rings of all the compounds studied are forced to take on the C-3′-endo conformation by the 3′,5′-cyclization. The conformations at the glycosidic bond of the adenosine and deoxyadenosine derivatives were determined as mixtures of syn and anti conformations by the DESERT method; the fractions of anti conformation for these derivatives were 0.58 and 0.41, respectively.
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