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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Hernia 3 (1999), S. 135-140 
    ISSN: 1248-9204
    Keywords: Aorta ; Abdominal ; Aortic aneurysm ; Hernia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Controversy exists in the literature regarding the incidence of incisional hernia formation after aortic reconstruction and the rate of incisional hernia formation in vertical midline and transverse incisions. We reviewed the incidence of incisional hernia after aneurysm (AAA) or occlusive disease (OCC) aortic operations and the incidence of incisional herniorrhaphy for vertical midline versus transverse incisions. Through a retrospective chart review of patients between 1970 and 1998, 618 patients who underwent incisional herniorrhaphy, 265 who underwent AAA repairs, and 331 who underwent OCC repairs were identified. These three groups were cross-referenced to identify patients who underwent incisional herniorrhaphy following aortic reconstruction. Patients were analyzed and compared according to presence of AAA or OCC and the incision and suture material used during the aortic repair. Thirty-six patients underwent incisional herniorrhaphy following aortic reconstruction. Twenty-six patients (9.8%) required incisional herniorrhaphy after AAA repair (22 vertical midline incisions, 4 transverse incisions). All ten patients (3%) who underwent incisional herniorrhaphy after OCC repair had vertical midline incisions. The difference in the incidence of incisional hernia repair (9.8% vs 3.0%) between AAA and OCC was statistically significant (p〈0.001). In AAA patients, there was an 11.3% incisional hernia repair rate after vertical midline incisions versus 5.6% after transverse incisions, but the difference was not statistically significant. We have demonstrated a significantly higher incidence of incisional hernia repair following aortic reconstruction for AAA than for OCC repair. Furthermore, we identified a trend towards increased incisional hernia repair after employing vertical midline incisions versus transverse incisions in AAA patients, and a significant risk for incisional hernia after AAA repair when absorbable suture was used.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Key words Opioid antagonists ; Oral self-administration ; Intravenous self-administration ; Alcohol ; Operant behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  These experiments evaluated the ability of naltrexone (NTX) to reduce selectively oral and IV ethanol-reinforced responding, and examined the ethanol-NTX interaction in terms of the competitive opioid antagonist property of NTX. Five rhesus monkeys self-administered ethanol or sucrose and concurrently available water. Ethanol concentration was varied from 0.25% to 8% (w/v). Naltrexone (0.032–0.32 mg/kg) or saline was given IM 30 min prior to some drinking sessions. NTX (0.32 mg/kg) reduced ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%). NTX (0.1 mg/kg) reduced ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. Thus, NTX (0.1 mg/kg) shifted the ethanol concentration-consumption curve down, in an insurmountable manner. NTX (0.1 and 0.32 mg/kg) also reduced reinforced responding for sucrose 100 g/l. In another experiment, three rhesus monkeys were given opportunities to self-administer ethanol IV. NTX (0.1 mg/kg) reduced the number of ethanol injections obtained by the monkeys at all ethanol doses tested (0.01, 0.032, and 0.1 g/kg per injection).The dose-effect curve was also shifted down. These results showed that NTX reduced behavior maintained by either ethanol or sucrose non-selectively. Furthermore, the ability of NTX to suppress ethanol-reinforced responding did not depend on the route of ethanol administration and was not overcome by increasing the concentration or dose per injection of ethanol.
    Type of Medium: Electronic Resource
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