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  • Articles  (4)
  • Articles: DFG German National Licenses  (4)
  • Indomethacin  (2)
  • Automatic Ventilation  (1)
  • Complications  (1)
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  • Articles  (4)
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  • Articles: DFG German National Licenses  (4)
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  • 1
    ISSN: 1435-2451
    Keywords: Patent ductus arteriosus ; Respiratory distress syndrome ; Indomethacin ; Ductus arteriosus persistens ; Atemnotsyndrom ; Indometacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Ligatur des offenen Ductus arteriosus ist auch bei kleinsten Frühgeborenen ein risikoarmer Eingriff und stellt immer eine vitale Indikation dar. Neben der Operation ist in indizierten Fällen auch der Verschluß mit Prostaglandin-Inaktivatoren möglich. Von 1976–1985 wurden 215 Frühgeborene behandelt. Bei 52 Säuglingen kam es zum Spontanverschluß. Bei 68 war Indomethacin erfolgreich. Bei 42 führte Indometacin nicht zum Verschluß, so daß eine Operation erforderlich wurde. 53 Säuglinge wurden wegen Kontraindikationen für Indometacin primär operiert. Die Gesamtletalität betrug 20%, wobei die kombinierte Gruppe die höchste Letalität aufwies.
    Notes: Summary Ligation of patent ductus arteriosus can be safely performed even in the smallest prematures and may be life-saving. Medical treatment with prostaglandin-inhibitors may be substituted in selected cases. From 1976–1985 a total of 215 prematures was treated. 52 of those experienced spontaneous closure. In 68 infants closure occurred following indomethacin-treatment. 48 had operation after failure of medical therapy and 53 with contraindications to indomethacin were primarily operated. The overall mortality reached 20% and was highest among those with combined medical and surgical treatment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Indomethacin ; Drug level monitoring ; Very low birth weight infants ; Ductus arteriosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract First results are described of individually tailored indomethacin dose rates employing on-line drug level monitoring for pharmacologically induced ductal constriction in very low birth weight infants with symptomatic patent ductus arteriosus (sPDA). In addition prolonged indomethacin therapy was introduced. From our data it appears that the effective threshold indomethacin level for the induction of ductus constriction has to be about 1000 ng/ml 10 h postdosing, while ductus closure can be maintained with a dose rate that exceeds a plasma level of 500 ng/ml for at least 1 week. These maintenance levels were also effective in completely suppressing the urinary metabolite excretion rates of PGI2 and PGE2, which are potential mediators of ductal relaxation. On-line indomethacin level monitoring appears to be practically essential for prolonged indomethacin therapy to overcome the marked variation of indomethacin disposition in preterm infants with sPDA.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Supraventricular tachycardia ; Cardioversion ; Chest thump ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on two cases of mechanical termination of supraventricular tachycardia by chest thump which were followed by serious complications. In a 3-year-old boy with an otherwise normal heart, incessant supraventricular tachycardia was converted to sinus rhythm by a single precordial thump. This, however was followed by thrombo-embolic infarction of the left-sided middle cerebral artery. In another case of a 9-year-old girl, recurrent episodes of supraventricular tachycardia were associated with Ebstein anomaly of the tricuspid valve. Chest thump was successful in terminating supraventricular tachycardia but induced a short run of ventricular tachycardia which terminated itself and was then followed by sinus rhythm. It is concluded that even a slight precordial thump implies undetermined risks in the acute management of supraventricular tachycardia in children and should therefore be abandoned in favour of other methods.
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  • 4
    ISSN: 1432-1750
    Keywords: pCO 2-Catheter Electrode ; Automatic Ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein neu entwickeltes System zur $$p_{a_{CO_2 } } $$ -geregelten Ventilation wird vorgestellt. Mit Hilfe einerp CO 2-Katheterelektrode (Fa. General Electric) wird kontinuierlich der arterielle Kohlensäurepartialdruck gemessen. Die in einenp CO2-Regler einlaufenden Potentiale werden mit einem variabel einstellbaren $$p_{a_{CO_2 } } $$ -Sollwert verglichen. Die Spannungs-differenz zwischen $$p_{a_{CO_2 } } $$ -Soll- und Istwert modifiziert die Ventilationsvorgabe eines mit Servo-Ventilen arbeitenden Beatmungsgerätes (Servo-Ventilator 900, Fa. Dräger) so lange nach, bis sich bei minimaler Regelabweichung $$p_{a_{CO_2 } } $$ -Soll- und Istwert entsprechen. Die Arbeitscharakteristika der einzelnen Glieder des Regelkreises werden besprochen.
    Notes: Abstract A newly developed system of $$p_{a_{CO_2 } } $$ -controlled automatic ventilation is demonstrated. ApCO 2-catheter electrode is used to monitor arterialpCO 2 continuously. The output voltage of thepCO 2 amplifier is fed into a regulator amplifier that compares it with a set voltage. The output voltage of the regulator controls an automatic respirator. All details of the automatic ventilation are described.
    Type of Medium: Electronic Resource
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